Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot infections

Abstract

The available evidence is limited, but suggests that adjunctive G-CSF treatment in people with a diabetic foot infection, including infected ulcers, does not appear to increase the likelihood of resolution of infection or healing of the foot ulcer. However, it does appear to reduce the need for surgical interventions, especially amputations, and the duration of hospitalisation. Clinicians might consider adding G-CSF to the usual treatment of diabetic foot infections, especially in patients with a limb-threatening infection, but it is not clear which patients might benefit.

Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers

“…PRP enrich the wound by multiple growth factors for cell migrations and neo-angiogenesis while PPP contains nutrients for healing [6].…”

Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine

“…By increasing the proliferation of leukocytes, G-CSF will lead to better management of systemic infections and hence will help patients to recover from CNS infections [31]. This adjunctive role of G-CSF in treating infections and sepsis was investigated in several studies [32][33][34][35][36]. A study in pneumococcal meningitis revealed encouraging results [36].…”

Risk Factors of Methicillin-Resistant Staphylococcus Aureus and Pseudomonas Infection in Diabetic Foot Ulcers in Korea

“…The available data are not sufficiently robust to support the routine use of this therapy [327][328][329][330][331][332][333].…”