Granulocyte-colony-stimulating factor-producing metaplastic carcinoma of the breast with significant elevation of serum interleukin-17 and vascular endothelial growth factor levels

Fukui, Yukiko; Kawashima, Masahiro; Kawaguchi, Kosuke; Takeuchi, Megumi; Hirata, Masahiro; Kataoka, Tatsuki R.; Sakurai, Takaki; Kataoka, Masako; Kanao, Shotaro; Nakamoto, Yuji; Hirata, Kimiko; Yoshimura, Masataka; Yoshikawa, Katsuhiro; Ishiguro, Hiroshi; Toi, Masakazu

doi:10.1007/s13691-018-0330-5

Cited by 13 publications

(14 citation statements)

References 28 publications

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“…We searched PubMed and Google Scholar using the keywords “G-CSF production” and “breast cancer”. As a result, there were only two well-reported cases of G-CSF-producing breast cancer [ 5 , 8 ]. According to Anano’s report, the diagnostic criteria for a G-CSF-producing tumor are extreme leukocytosis, elevated G-CSF activity, a decrease in the WBC count after tumor resection, and proof of G-CSF production in the tumor [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…We treated a patient with G-CSF-producing malignant phyllodes tumor of the breast. It was a triple-negative type malignant tumor that was mainly composed of atypical stromal cells as in the past two reported cases [ 5 , 11 ]. Including this case, a G-CSF-producing tumor has presented as a malignant tumor mainly composed of stromal cells.…”

Section: Discussionmentioning

confidence: 99%

“…G-CSF-producing carcinomas progress rapidly and have poor prognosis. [ 5 ] We report a case of G-CSF-producing malignant phyllodes tumor of the breast.…”

Section: Introductionmentioning

confidence: 99%

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Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

et al. 2021

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Background Granulocyte-colony stimulating factor (G-CSF)-producing tumors can cause leukocytosis despite an absence of infection. G-CSF-producing tumors have been reported in various organs such as the lung, esophagus, and stomach but rarely in the breast. We report a case of G-CSF-producing malignant phyllodes tumor of the breast. Case presentation An 84-year-old woman visited our hospital complaining of a lump in her left breast without fever and pain. Laboratory tests revealed elevated white blood cell (WBC) count and G-CSF levels. A malignant tumor of the breast was diagnosed by core needle biopsy. We performed a total mastectomy and sentinel lymph node biopsy. The tumor was identified as a G-CSF-producing malignant phyllodes tumor. Within 7 days after surgery, the patient’s WBC count and G-CSF level had decreased to normal levels. She is alive without recurrence 13 months after surgery. Conclusions We encountered a rare case of G-CSF-producing malignant phyllodes tumor of the breast. PET–CT revealed diffuse accumulation of FDG in the bone. Phyllodes tumors need to be differentiated from bone metastasis, lymphoma, and leukemia. We must be careful to not mistake this type of tumor for bone marrow metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

et al. 2021

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“…The patient is currently alive without relapse at 30 months postoperative. breast cancer, including our case [1][2][3][4][5][6][7][8][9][10][11][12] (Table 1). Such tumors have a large proportion of special tissue type, and squamous cell carcinoma is a frequent type.…”

Section: Postoperative Coursementioning

confidence: 99%

A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast

et al. 2021

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A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. However, serum procalcitonin and β-D-glucan levels were normal, and no apparent infection focus was detected, although her serum granulocyte colony-stimulating factor (G-CSF) level was markedly elevated to 42.7 pg/mL. Therefore, a G-CSF-producing breast cancer was suspected. A pathological analysis of the surgical specimen revealed a squamous cell carcinoma of the breast (pT2N0 [i+] M0 stage ∥A). Right mastectomy (with the resection of the pectoralis major muscle), axillary lymph node dissection, and split layer grafting were performed. The leucocyte count and serum G-CSF level decreased on postoperative day (POD) 1 and normalized on POD 6. As adjuvant chemotherapy, 4 cycles of a combination chemotherapy with adriamycin and cyclophosphamide and 12 cycles of weekly paclitaxel were administered. After chemotherapy, the patient also underwent postmastectomy radiotherapy. Currently, 30 months after surgery, the patient is alive and well with neither progression nor distant metastasis. G-CSF-producing breast cancers tend to rapidly grow such as in the current case; thus, surgery should be performed immediately, followed by appropriate adjuvant treatment.

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“…Some studies have reported that serum G-cSF levels are significantly higher in breast cancer patients compared with healthy controls (48,(59)(60)(61)(62)(63). lawicki et al (60), demonstrated that the plasma levels of G-CSF and M-CSF were significantly increased in 54 breast cancer patients compared with in control group patients.…”

Section: G-csf Expression In Breast Cancermentioning

confidence: 99%

The role of granulocyte colony‑stimulating factor in breast cancer development: A review

Liu

Yan

et al. 2020

Mol Med Report

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Granulocyte-colony-stimulating factor (G-cSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-cSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-cSF (rhG-cSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G-cSF plays an important role in cancer progression. G-cSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G-cSF has an adverse effect. The current review provides an overview of G-cSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy. Contents 1. introduction 2. Structure of the G-cSF gene 3. regulation of G-cSF gene expression 4. The G-cSF receptor 5. G-cSF expression in breast cancer 6. direct effects of G-cSF on breast cancer 7. role of tumor microenvironment in the effect of G-cSF on breast cancer 8. conclusions

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Granulocyte-colony-stimulating factor-producing metaplastic carcinoma of the breast with significant elevation of serum interleukin-17 and vascular endothelial growth factor levels

Cited by 13 publications

References 28 publications

Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case

A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast

The role of granulocyte colony‑stimulating factor in breast cancer development: A review

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