Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

Neves, Rafael Scarpa da Costa; Tudesco, Ivanda de Souza Silva; Jardim, Anaclara Prada; Caboclo, Luís Otávio Sales Ferreira; Lancellotti, Carmen Lúcia Penteado; Ferrari-Marinho, Taíssa; Hamad, Ana Paula Andrade; Marinho, Murilo Martinez; Centeno, Ricardo Silva; Cavalheiro, Ésper A.; Scorza, Carla A.; Yacubian, Elza Márcia Targas

doi:10.1016/j.seizure.2012.07.008

Cited by 19 publications

(10 citation statements)

References 40 publications

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“…The dense associative network and the laminar organization, in which cell bodies are tightly packed, are evident also in insect's mushroom bodies (Menzel and Giurfa, ; Hochner, ) and mammalian's hippocampus (Neves et al., ; Bartsch and Wulff, ).…”

Section: Discussionmentioning

confidence: 99%

Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa

2017

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Organisms showing a complex and centralized nervous system, such as teleosts, amphibians, reptiles, birds and mammals, and among invertebrates, crustaceans and insects, can adjust their behavior according to the environmental challenges. Proliferation, differentiation, migration, and axonal and dendritic development of newborn neurons take place in brain areas where structural plasticity, involved in learning, memory, and sensory stimuli integration, occurs. Octopus vulgaris has a complex and centralized nervous system, located between the eyes, with a hierarchical organization. It is considered the most "intelligent" invertebrate for its advanced cognitive capabilities, as learning and memory, and its sophisticated behaviors. The experimental data obtained by immunohistochemistry and western blot assay using proliferating cell nuclear antigen and poli (ADP-ribose) polymerase 1 as marker of cell proliferation and synaptogenesis, respectively, reviled cell proliferation in areas of brain involved in learning, memory, and sensory stimuli integration. Furthermore, we showed how enriched environmental conditions affect adult neurogenesis.

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Section: Discussionmentioning

confidence: 99%

Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa

2017

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“…Furthermore, two other studies also found no relationship between neuronal cell counts of the right hippocampus and other nonverbal memory measures (Rausch and Babb, ; Baxendale et al, ). However, there may be other relevant neuropathological markers beyond neuronal cell loss: A recent study showed that the presence of granule cell dispersion was associated with worse presurgical nonverbal memory performance in right (vs. left) mTLE (Neves et al, ).…”

Section: Discussionmentioning

confidence: 99%

The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy

et al. 2013

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Studies on hippocampal cell loss in epilepsy have produced diverging evidence as to which subfields are specifically related to memory. This may be due to rather small and often heterogeneous samples, or to different memory measures. Therefore, the current study examined hippocampal cell densities and memory in a large sample of patients with solely mesial temporal lobe epilepsy (mTLE), employing measures with proven sensitivity to mesiotemporal pathology. In 104 patients who had undergone epilepsy surgery for mTLE, we evaluated the role of segmental hippocampal cell loss and its underlying factor structure with regard to presurgical verbal and figural memory while controlling for side-of-surgery and hemispheric dominance. First of all, patients showed material-specific memory impairment concordant with the lateralization of epilepsy. Factor analysis of segmental cell loss revealed a single factor reflecting the overall integrity of the hippocampus. The overall pathological status of the left hippocampus correlated with verbal memory parameters (r = 0.33-0.34, P < 0.05), especially when controlling for atypical hemispheric dominance (r = 0.50-0.57, P < 0.01), and explained up to 33% of the observed variance. Further analyses revealed no superior role of a single subfield or cell loss pattern for memory performance. No systematic relations between neuronal cell densities of the right hippocampus and memory function were found, nor did left or right hippocampal pathology explain figural memory parameters. The results suggest that the overall pathological status of the left hippocampus - rather than a specific subfield pathology - is predictive for verbal memory in mTLE. The finding that figural memory parameters, although sensitive to right mTLE, were not related to neuronal cell densities of the right hippocampus, puts the left/right hippocampus verbal/nonverbal memory dichotomy into perspective.

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“…In addition, GCD is variably described in ILAE HS types 1, 2, and 3 (Blumcke et al., ; Thom et al., ), and may also occur in patients without hippocampal neuronal cell loss (Blumcke et al., ). Evidence currently suggests GCD as result of Reelin deficiency in the DG (Haas et al., ; Haas & Frotscher, ; Kobow et al., ), and that the presence of GCD is associated with greater cell loss in the hilus, an older age at epilepsy surgery, and longer epilepsy duration (Blumcke et al., ; Neves et al., ). The involvement of granule cells in the mechanisms of plasticity and memory formation also suggests that depletion of granule cells, in particular within the internal limb (Altman & Bayer, ), could be related to memory impairment in patients with TLE (Pauli et al., ; Blumcke et al., ; Coras et al., ; Neves et al., ).…”

Section: The Ilae Classification Of Hs In Patients With Tlementioning

confidence: 99%

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from theILAECommission on Diagnostic Methods

et al. 2013

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Summary Hippocampal sclerosis (HS) is the most frequent histopathology encountered in patients with drug‐resistant temporal lobe epilepsy (TLE). Over the past decades, various attempts have been made to classify specific patterns of hippocampal neuronal cell loss and correlate subtypes with postsurgical outcome. However, no international consensus about definitions and terminology has been achieved. A task force reviewed previous classification schemes and proposes a system based on semiquantitative hippocampal cell loss patterns that can be applied in any histopathology laboratory. Interobserver and intraobserver agreement studies reached consensus to classify three types in anatomically well‐preserved hippocampal specimens: HS International League Against Epilepsy (ILAE) type 1 refers always to severe neuronal cell loss and gliosis predominantly in CA1 and CA4 regions, compared to CA1 predominant neuronal cell loss and gliosis (HS ILAE type 2), or CA4 predominant neuronal cell loss and gliosis (HS ILAE type 3). Surgical hippocampus specimens obtained from patients with TLE may also show normal content of neurons with reactive gliosis only (no‐HS). HS ILAE type 1 is more often associated with a history of initial precipitating injuries before age 5 years, with early seizure onset, and favorable postsurgical seizure control. CA1 predominant HS ILAE type 2 and CA4 predominant HS ILAE type 3 have been studied less systematically so far, but some reports point to less favorable outcome, and to differences regarding epilepsy history, including age of seizure onset. The proposed international consensus classification will aid in the characterization of specific clinicopathologic syndromes, and explore variability in imaging and electrophysiology findings, and in postsurgical seizure control.

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Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy

Abstract: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined.

Cited by 19 publications

References 40 publications

Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa

Enriched Environment Increases PCNA and PARP1 Levels in Octopus vulgaris Central Nervous System: First Evidence of Adult Neurogenesis in Lophotrochozoa

The overall pathological status of the left hippocampus determines preoperative verbal memory performance in left mesial temporal lobe epilepsy

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from theILAECommission on Diagnostic Methods

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