Granulation of indomethacin and a hydrophilic carrier by fluidized hot melt method: The drug solubility enhancement

Andrade, Toni Carvalho de; Martins, Ronei Ximenes; Freitas, Luís Alexandre Pedro de

doi:10.1016/j.powtec.2014.07.030

Cited by 14 publications

(7 citation statements)

References 29 publications

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“…Figure 10 shows maximum performances of the granulation process at highest velocity and lowest temperature at which we achieved the largest weight of the granulated urea particles. A comparison of our findings with the results of Dimin et al [26] and Andrade et al [6] vindicate that number of granulated particles increase by increasing air velocity. It is easier to produce particles with specific size by adjusting air velocity.…”

Section: Resultssupporting

confidence: 84%

“…The rate of top spraying is significant to control bed humidity and the granulated urea particle size [53]. Binder flow rate is statistically significant akin to findings of Andrade et al [6]. Figure 15 represents effects of binder concentration and binder volumetric flow rate on granulated urea weight.…”

Section: Resultsmentioning

confidence: 92%

“…Particle size distribution (PSD) was studied using one-dimensional (1D) population balance model (PBM) for the granulation of CaCO 3 and lactose using PEG and hydroxypropyle as the binder solution [5]. Box-Behnken method was used to analyse the effect of atomizing air flow rate, binder spray rate and binder volume on granulation performance of lactose using PEG 4000 mix with indomethacin in a fluidized bed granulator [6]. Effect of spray rate, droplet size, and operating temperature was investigated on PSD of substrate particles in a fluidized bed granulator using PEG 1500 as a binder.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Biodegradable Binder Properties and Operating Conditions on Growth of Urea Particles in a Fluidized Bed Granulator

et al. 2019

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Granulation is an important step during the production of urea granules. Most of the commercial binders used for granulation are toxic and non-biodegradable. In this study, a fully biodegradable and cost-effective starch-based binder is used for urea granulation in a fluidized bed granulator. The effect of binder properties such as viscosity, surface tension, contact angle, penetration time, and liquid bridge bonding force on granulation performance is studied. In addition, the effect of fluidized bed process parameters such as fluidizing air inlet velocity, air temperature, weight of primary urea particles, binder spray rate, and binder concentration is also evaluated using response surface methodology. Based on the results, binder with higher concentration demonstrates higher viscosity and higher penetration time that potentially enhance the granulation performance. The viscous Stokes number for binder with higher concentration is lower than critical Stokes number that increases coalescence rate. Higher viscosity and lower restitution coefficient of urea particles result in elastic losses and subsequent successful coalescence. Statistical analysis indicate that air velocity, air temperature, and weight of primary urea particles have major effects on granulation performance. Higher air velocity increases probability of collision, whereby lower temperature prevents binder to be dried up prior to collision. Findings of this study can be useful for process scale-up and industrial application.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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Effect of Biodegradable Binder Properties and Operating Conditions on Growth of Urea Particles in a Fluidized Bed Granulator

et al. 2019

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“…Solution crystallization, humidity, melt cooling, freeze‐dryer, quench cooling, sublimation, and milling were applied to investigate the crystallization and polymorphism of LEV in detail. To the best of our knowledge, several techniques, including melt cooling, quench cooling, and milling, can convert solid drugs to amorphous and metastable forms . However, the results reveal that no new solid forms were formed when various methods of solid‐state transformation were performed.…”

Section: Resultsmentioning

confidence: 98%

An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form

Xiong

Guo

et al. 2015

Journal of Pharmaceutical Sciences

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“…Sa druge strane, supstance sa izrazito niskom temperaturom topljenja mogu dovesti do omekšavanja i lepljenja proizvoda u toku rukovanja i čuvanja. Pregled uobičajeno korišćenih sredstava za vezivanje pri granulaciji topljenjem dat je u Tabeli I. Hidrofilna i amfifilna sredstva za vezivanje se mogu koristiti sa ciljem postizanja trenutnog oslobađanja aktivne supstance i poboljšanja bioraspoloživosti slabo rastvorljivih supstanci (11)(12)(13)(14)(15), dok su hidrofobna sredstva za vezivanje pogodna za formulaciju preparata sa produženim oslobađanjem (16)(17)(18)(19)(20).…”

Section: Vrsta Sredstva Za Vezivanjeunclassified

Melt granulation as an alternative technique in solid dosage forms manufacture

Aleksić¹,

Djuriš²,

Cvijić³

et al. 2015

Arh farmaciju

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Konvencionalne metode granulacije pokazuju brojne nedostatke što je razlog za sve veće interesovanje i ulaganje u razvoj alternativnih metoda. Granulacija topljenjem predstavlja alternativnu metodu koja ima značajan potencijal za primenu u proizvodnji čvrstih farmaceutskih oblika. Podrazumeva primenu vezivnih sredstava koja imaju relativno nisku temperaturu topljenja (50 do 100°C), a čiji rastop omogućava aglomeraciju čestica praška. Kako rastvarač nije potreban, izbegava se faza sušenja, pa su broj procesnih koraka i troškovi smanjeni u odnosu na tradicionalni postupak vlažne granulacije. Postupak je pogodan za aktivne supstance podložne hidrolizi, a izborom odgovarajućeg vezivnog sredstva može se primeniti za izradu preparata sa modifikovanim ili trenutnim oslobađanjem, uz poboljšanje bioraspoloživosti slabo rastvorljivih aktivnih supstanci, kao i u cilju maskiranja gorkog ukusa. Granulacija topljenjem se može izvoditi u uređajima koji se uobičajeno koriste za vlažnu granulaciju, kao što su mikseri/granulatori velike brzine, uređaji tipa fluidizirajućeg sistema, ekstruderi. Brojni faktori formulacije, procesni parametari, kao i faktori vezani za dizajn i vrstu opreme mogu uticati na mehanizam aglomeracije i karakteristike dobijenih granula. Dobro kontrolisan postupak granulacije topljenjem podrazumeva podrobno poznavanje i razumevanje uticaja ovih faktora, zbog čega ova oblast i dalje zahteva intenzivan, a često i multidisciplinarni istraživački rad.

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Granulation of indomethacin and a hydrophilic carrier by fluidized hot melt method: The drug solubility enhancement

Cited by 14 publications

References 29 publications

Effect of Biodegradable Binder Properties and Operating Conditions on Growth of Urea Particles in a Fluidized Bed Granulator

Effect of Biodegradable Binder Properties and Operating Conditions on Growth of Urea Particles in a Fluidized Bed Granulator

An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form

Melt granulation as an alternative technique in solid dosage forms manufacture

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