Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction

Forget, Benoît; Pushparaj, Abhiram; Foll, Bernard Le

doi:10.1016/j.biopsych.2010.01.029

Cited by 142 publications

(134 citation statements)

References 55 publications

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“…The importance of the insula in drug craving (Contreras et al, 2007;Naqvi et al, 2007;Hollander et al, 2008;Forget et al, 2010;Abdolahi et al, 2010;Scott and Hiroi, 2011) was confirmed during the CPP extinction trials run under reversible inactivation of pIC with bupivacaine ( Figure 5b). We report here that the repeated pairing of context with the inactivation of pIC resulted in a protracted loss of CPP, at least up to 24 days after the last conditioning with amphetamine.…”

Section: Discussionmentioning

confidence: 71%

“…The risk of drug craving increases with stress, drug intake, or learned cues such as drug-related context (O'Brien, 1997;Volkow and Li, 2005). Drug craving critically depends on the function of the insula (Contreras et al, 2007;Naqvi et al, 2007;Hollander et al, 2008;Forget et al, 2010;Abdolahi et al, 2010;Scott and Hiroi, 2011), a key cortical region for interoception, that is, the perception of bodily states, emotions, and needs (Craig, 2004;Damasio et al, 2000), such as the need for drug in addicts. The primary interoceptive posterior insula (pIC) of rats is considered a primary sensory area that receives viscerosensory (Cechetto and Saper, 1987) and nociceptive nonspecific (Gauriau and Bernard, 2004) thalamic inputs; pIC is reciprocally connected to the rostral agranular insular cortex (RAIC) through intermediate insular relays (Shi and Cassell, 1998;Kimura et al, 2010), whereas the RAIC may be considered a high-order interoceptive cortex (see below and Discussion).…”

Section: Introductionmentioning

confidence: 99%

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A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

Contreras

Billeke

Vicencio

et al. 2012

Neuropsychopharmacol

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Drug craving critically depends on the function of the interoceptive insular cortex, and may be triggered by contextual cues. However, the role of the insula in the long-term memory linking context with drug craving remains unknown. Such a memory trace probably resides in some neocortical region, much like other declarative memories. Studies in humans and rats suggest that the insula may include such a region. Rats chronically implanted with bilateral injection cannulae into the high-order rostral agranular insular cortex (RAIC) or the primary interoceptive posterior insula (pIC) were conditioned to prefer the initially aversive compartment of a 2-compartment place preference apparatus by repeatedly pairing it to amphetamine. We found a reversible but long-lasting loss (ca. 24 days) of amphetamineconditioned place preference (CPP) and a decreased expression in the insula of zif268, a crucial protein in memory reconsolidation, when anisomycin (ANI) was microinjected into the RAIC immediately after the reactivation of the conditioned amphetamine/context memory. ANI infusion into the RAIC without reactivation did not change CPP, whereas ANI infusion into pIC plus caused a 15 days loss of CPP. We also found a 24 days loss of CPP when we reversibly inactivated pIC during extinction trials. We interpret these findings as evidence that the insular cortex, including the RAIC, is involved in a context/drug effect association. These results add a drug-related memory function to the insular cortex to the previously found role of the pIC in the perception of craving or malaise.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

Contreras

Billeke

Vicencio

et al. 2012

Neuropsychopharmacol

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“…In both left and right INS, PSEs resulted in less deactivation than PNEs, an effect that was not observed for standard environments and proximal cues. The INS has been proposed as a critical substrate of tobacco use: smokers with insula damage exhibit increased likelihood of quitting smoking Naqvi et al, 2007); selfreported craving (Kuhn and Gallinat, 2011;Tang et al, 2012) and cessation outcomes (Janes et al, 2010) are correlated with insula reactivity to proximal smoking cues; and inactivation of insula decreases proximal cue-provoked nicotine seeking in rodents (Forget et al, 2010;Pushparaj et al, 2013). Less is known about the role of the insula in contextual drug effects; however, in a recent study, insula inactivation in rats led to disruption of amphetamine CPP (Contreras et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence

McClernon

Conklin

Kozink

et al. 2015

Neuropsychopharmacol

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Environments associated with prior drug use provoke craving and drug taking, and set the stage for lapse/relapse. Although the neurobehavioral bases of environment-induced drug taking have been investigated with animal models, the influence of drugenvironments on brain function and behavior in clinical populations of substance users is largely unexplored. Adult smokers (n = 40) photographed locations personally associated with smoking (personal smoking environments; PSEs) or personal nonsmoking environment (PNEs). Following 24-h abstinence, participants underwent fMRI scanning while viewing PSEs, PNEs, standard smoking and nonsmoking environments, as well as proximal smoking (eg, lit cigarette) and nonsmoking (eg, pencil) cues. Finally, in two separate sessions following 6-h abstinence they viewed either PSEs or PNEs while cue-induced self-reported craving and smoking behavior were assessed. Viewing PSEs increased blood oxygen level-dependent signal in right posterior hippocampus (pHPC; F 2,685 = 3.74, po0.024) and bilateral insula (left: F 2,685 = 6.87, p = 0.0011; right: F 2,685 = 5.34, p = 0.005). In the laboratory, viewing PSEs, compared with PNEs, was associated with higher craving levels (F 2,180 = 18.32, po0.0001) and greater ad lib smoking (F 1,36 = 5.01, p = 0.032). The effect of PSEs (minus PNEs) on brain activation in right insula was positively correlated with the effect of PSEs (minus PNEs) on number of puffs taken from a cigarette (r = 0.6, p = 0.001). Our data, for the first time in humans, elucidates the neural mechanisms that mediate the effects of real-world drug-associated environments on drug taking behavior under conditions of drug abstinence. These findings establish targets for the development and evaluation of treatments seeking to reduce environment provoked relapse.

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“…Studies involving animal models and imaging research are able to further increase understanding regarding the mechanisms and safety of the treatment. Previous studies have reported that there may be a specific ideal target of DBS treatment for habituation (Table III) (53)(54)(55)(56)(57). However, it should be noted that the potential targets are not mutually independent and selection of the ideal target requires more support from clinical and research data due to potentially overlapping mechanisms and functions.…”

Section: Targets Of Dbs For Ocdmentioning

confidence: 99%

Advanced research on deep brain stimulation in treating mental disorders (Review)

et al. 2017

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Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction

Cited by 142 publications

References 55 publications

A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

A Role for the Insular Cortex in Long-Term Memory for Context-Evoked Drug Craving in Rats

Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence

Advanced research on deep brain stimulation in treating mental disorders (Review)

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