Granular Cell Tumors

Kershisnik, Matthew M.; Batsakis, John G.; Mackay, Bruce

doi:10.1177/000348949410300514

Cited by 50 publications

(27 citation statements)

References 12 publications

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“…Metastases may occur to the regional lymph nodes, lungs, bones, and viscera. 12 A recent cytogenetic analysis of a malignant GCT demonstrated chromosomal abnormalities, which had been previously reported as malignant peripheral nerve sheath tumors and further substantiating the hypothesis of neuroectoderm origin of the neoplastic cells. 13 In conclusion, GCT is an uncommon tumor of the larynx.…”

Section: Discussionsupporting

confidence: 66%

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Laryngeal Granular Cell Tumor

et al. 2008

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Section: Discussionsupporting

confidence: 66%

“…12 The malignant GCT's are usually larger in size, more invasive, and grow more rapidly. Histologically, there is increased cellularity and cellular pleomorphism, necrosis, and increased mitotic activity.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal Granular Cell Tumor

et al. 2008

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“…In 5–15% of cases, they may present as multiple nodules. However, multiple lesions mostly occur in the intradermal and subcutaneous tissue, although rare cases have been documented in the oral mucosa as well.…”

Section: Discussionmentioning

confidence: 99%

Granular cell tumour of the tongue in a 17‐year‐old orthodontic patient: a case report

Hita-Davis¹,

Edwards

Conley

et al. 2013

Oral Surgery

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To describe the clinical presentation of a granular cell tumour (GCT) in an orthodontic patient, as well as discuss its aetiology and treatment of choice. We present a case of GCT of the tongue in an otherwise healthy 17‐year‐old male patient along with a brief review of literature on GCTs. The lesion was surgically excised and orthodontic treatment was successfully finalised. Clinically, GCTs are indistinguishable from other benign connective tissue and neural tissue neoplasms and may be found in any site, with cases commonly involving the gastrointestinal system, breast and lung. However, over 50% of cases involve the head and neck, with the tongue being the most frequently involved site (65–85% of oral GCTs). GCTs demonstrate a close anatomical relationship with peripheral nerve fibres and demonstrate the presence of myelin and axon‐like structures thus lending credence to their neural origin. The treatment of choice for GCTs is conservative surgical excision. Because GCTs present with a potential for recurrence, follow‐up is recommended. While the primary focus of orthodontic treatment is the position of the teeth within the orofacial complex, the health and wellness of the patient and his/her surrounding oral tissues always take precedence. This case demonstrates the importance of routine physical examination of the intraoral and extraoral tissues during routine orthodontic care.

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“…9 Tumors that show cellular and nuclear pleomorphism, necrosis, and mitotic activity have malignant potential. 7,9 A diagnosis of a malignancy, according to some, can only be substantiated by finding metastatic lesions with histologic features similar to the primary tumor. 7 The GCT was first described in 1926 by Abrikossoff.…”

Section: Commentmentioning

confidence: 99%

“…7 Recurrences are noted in 8% to 12% of GCTs with positive surgical margins. 9 The role and effectiveness for chemotherapy and radiotherapy in malignant GCTs is unproven. 7,14 Granular cell tumor composed of cells with granular cytoplasm and round to spindle-shaped nuclei (hematoxylin-eosin, original magnification ϫ100).…”

Section: Commentmentioning

confidence: 99%

Eagle Syndrome Produced by a Granular Cell Tumor

Philipp

Barnes²,

Carrau³

2001

Arch Otolaryngol Head Neck Surg

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Eagle syndrome includes elicitation of pain on swallowing, turning the head, or extending the tongue. The syndrome is thought to be caused by irritation of the glossopharyngeal nerve, most commonly caused by its impingement against an elongated styloid process. We present a rare case of a granular cell tumor presenting as Eagle syndrome. Granular cell tumors orignate from Schwann cells and are most common in the subcutaneous tissue of the head, neck, and oral cavity, especially the tongue. A granular cell tumor is typically benign and solitary, rarely malignant. The differential diagnosis, diagnostic algorithm, and treatment are presented.

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Granular Cell Tumors

Cited by 50 publications

References 12 publications

Laryngeal Granular Cell Tumor

Laryngeal Granular Cell Tumor

Granular cell tumour of the tongue in a 17‐year‐old orthodontic patient: a case report

Eagle Syndrome Produced by a Granular Cell Tumor

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