Granular cell myoblastoma of the head and neck

Noonan, John D.; Norton, Charles E.; Old, William L.; Stokes, Thomas Lane

doi:10.1016/0002-9610(79)90430-6

Cited by 41 publications

(17 citation statements)

References 23 publications

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“…Most authors agree that current evidence is most supportive of Schwann cell origin of these tumors 15 . The majority of GCTs are benign, and they often present as solitary dermal nodules, but 3% to 15% of GCTs occur as multiple lesions, 4,16 and approximately 1% to 7% are malignant 1,16 . In 1955, Gamboa classified malignant granular cell myoblastoma into two types, both of which had a poor prognosis; one type was clinically malignant and histologically benign, and the other type was clinically and histologically malignant 17 .…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell tumors (GCTs) are uncommon neoplasms of neural origin. Traditionally, the treatment of choice for GCTs has been routine surgical excision 1–4 . All reported cases of GCTs treated with Mohs micrographic surgery (MMS) are reviewed.…”

mentioning

confidence: 99%

“…Although GCTs have been reported in almost every location throughout the body, the most common location is the oral cavity, particularly the tongue 11,12 . GCTs present most commonly during the third to sixth decades of life 1,4,5,11 and are more common in women and African Americans 1,11,13 …”

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confidence: 99%

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Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Youssef

Hinshaw

Longley

et al. 2010

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Youssef

Hinshaw

Longley

et al. 2010

Dermatologic Surgery

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“…A recurrence after excision has been reported in 8% of cases [ 31. Malignant transformation occurs, although very rarely [28,29], and metastatic spread occurs via the lymphatics [35]. No spontaneous regression has been reported, and multicentricity is reported in up to 7-16% of cases [3,36].…”

Section: Sloo Proteinmentioning

confidence: 99%

Granular cell lesions in head and neck: A clinicopathological study

Fliss

Puterman

Zirkin

et al. 1989

Journal of Surgical Oncology

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Twenty-five cases of granular cell lesions in the region of the head and neck are presented. The adult form (18 cases) was more frequent in women, and the most frequent sites were the tongue, the skin, and subcutaneous tissues, followed by the lip and buccal mucosa. One lesion occurred in the larynx. The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible. Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides. Embryonic antigen was present in the cells of all the congenital cases and in three-quarters of the adult cases. The significance of the histological and immunohistochemical findings is discussed. We conclude that the congenital and adult lesions are similar morphologically but are not necessarily of similar histogenesis. The findings with respect to S100 protein favor a neural (Schwann cell) origin of the adult granular cell tumor, but not the congenital form.

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“…Most patients are middle-aged, with a peak incidence in the fourth through the sixth decades of life. It is widely accepted that the GCT can occur virtually in all parts of the body; nevertheless, head and neck areas are the most affected sites by this type of tumours, with more than two-thirds of those cases diagnosed in the tongue [6]. GCT in the orbit is very rare [7–9]; additionally, malignant orbital GCT was scarcely reported [10–12].…”

Section: Introductionmentioning

confidence: 99%

Surgical Excision of Orbital Progressive Granular Cell Tumour

Germanò

Elbadawy

Ponzin

et al. 2015

Case Reports in Ophthalmological Medicine

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Granular cell tumour (GCT) is mostly benign lesion first described by Abrikossoff and named after him. Most cases are reported in the head and neck area, where the tongue is the most common site. Here we review previous cases in the literature for GCT in the orbit and present a new case. A 49-year-old male presented with apparent exophthalmos. Examination of the patient revealed the presence of a mass in the bottom side of the orbit. A substantial progress was noted after two months from the initial examination using computed tomography (CT) scan. An orbital mass was extracted and histological analysis showed signs typical for GCT. Immunohistochemistry was positive for S-100; the biopsy showed no mitotic or necrotic areas. Proptosis was resolved after surgery and a six-year follow-up CT scan was performed. We conclude that rapid progress of the tumour does not necessarily suggest malignancy.

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Granular cell myoblastoma of the head and neck

Cited by 41 publications

References 23 publications

Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Mohs Surgical Excision of a Granular Cell Tumor with Plexiform Features on the Arm of a 7-Year-Old Child

Granular cell lesions in head and neck: A clinicopathological study

Surgical Excision of Orbital Progressive Granular Cell Tumour

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