Granular cell ameloblastoma showing desmoplasia

Gupta, Suchitra; Grewal, Harshaminder Kaur; Sah, Kunal

doi:10.5144/0256-4947.2012.30.5.1342

Cited by 9 publications

(14 citation statements)

References 11 publications

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“…The granular cells are a transitional or matured phase in the life cycle of ameloblastomas, starting with normal stellate reticulum-like cells, leading to a production of granules and finally resulting in degeneration and the formation of cystic areas, differing from the aggressive tumor nature reported previously 44. However, the granular cell type is rare and accounts for only 4% of ameloblastomas 45…”

Section: Ameloblastomamentioning

confidence: 98%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Lee

Kim

2013

Korean J Pathol

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Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.

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Section: Ameloblastomamentioning

confidence: 98%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Lee

Kim

2013

Korean J Pathol

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“…Granular cell ameloblastoma accounts for approximately 3.5%-5% of all ameloblastoma. [11][12][13] Hartman reported that the average age of the patients at the first visit was 40.7 years and that there was no difference between genders in his 20 cases. 11 The WHO classification of odontogenic tumors mentions that granular ameloblastomas are characterized by granular cells located within the center of the follicles.…”

Section: Discussionmentioning

confidence: 99%

“…Granular cell ameloblastoma accounts for approximately 3.5%–5% of all ameloblastoma . Hartman reported that the average age of the patients at the first visit was 40.7 years and that there was no difference between genders in his 20 cases .…”

Section: Discussionmentioning

confidence: 99%

Granular cell ameloblastoma: Case report of a particular ameloblastoma histologically resembling oncocytoma

Fujita

Kawasaki

Hirota

et al. 2014

Pathology International

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Granular cell ameloblastoma is classified as a histological subtype of solid/multicystic ameloblastoma. Usual granular cell ameloblastoma is histologically characterized by granular changes of stellate‐like cells located in the inner portion of the epithelial follicles. Here we report a case of another type of granular cell ameloblastoma, showing predominant anastomosing double‐stranded trabeculae of granular cells. This type of granular cell ameloblastoma is extremely rare, and the World Health Organization classification does not contain the entity. We tentatively termed it ‘anastomosing granular cell ameloblastoma’ in this report. The present case suggests the importance of differential diagnosis because the histology of ‘anastomosing granular cell ameloblastoma’ resembles that of salivary gland oncocytoma rather than that of usual granular cell ameloblastoma. The trabeculae observed in our case continued to the peripheral cells of a small amount of epithelial sheets of plexiform ameloblastoma, and the tumor cells were positive for CK19, which is regarded as an immunohistochemical marker of odontogenic epithelium. Similar to usual granular cell ameloblastoma, the tumor cells had CD68‐positive granules. For precise diagnosis of this condition, immunohistochemistry using CK19 and CD68, as well as detailed histological observation, are recommended.

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“…The Granular cell ameloblastoma (G.C.A) once considered as the most aggressive variant of ameloblastoma but according to the recent studies it is believed that the earlier belief was a myth. 14 Numerous theories have been proposed on the origin and nature of these granular cells in ameloblastomas. The granular cells are epithelial in origin and several ultrastructural studies describe them as lysosome.…”

Section: Discussionmentioning

confidence: 99%

Kompleks Histolojik Paternler İçeren Periferal Ameloblastoma

Bajpai¹,

Pardhe²

2015

Cukurova Medical Journal

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Peripheral ameloblastoma is a relatively uncommon neoplasm of odontogenic origin histologically resembles the classic ameloblastoma and derived from epithelial and/or mesenchymal elements being part of the tooth forming apparatus. It can be originated in the soft tissue of oral cavity namely alveolar mucosa or gingiva. Among histopathological pattern the most common is acanthomatous followed by plexiform and follicular. Granular cell ameloblastoma once considered as the most aggressive variant of ameloblastoma but according to the recent studies it is believed that the earlier belief was a myth. We report a case of peripheral ameloblastoma in a 44 year old lady, histopathologicaly showing combined features of granular cell, plexiform, acanthomatous, follicular and desmoplastic ameloblastoma. As per our best knowledge this is the first case of its type.

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Granular cell ameloblastoma showing desmoplasia

Cited by 9 publications

References 11 publications

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Granular cell ameloblastoma: Case report of a particular ameloblastoma histologically resembling oncocytoma

Kompleks Histolojik Paternler İçeren Periferal Ameloblastoma

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