Gram-scale synthesis of splat-shaped Ag–TiO₂ nanocomposites for enhanced antimicrobial properties

Abstract

The control over contagious diseases caused by pathogenic organisms has become a serious health issue. The extensive usage of antibiotics has led to the development of multidrug-resistant bacterial strains. In this regard, metal-oxide-based antibacterial nanomaterials have received potential research interest due to the efficient prevention of microorganism growth. In this study, splat-shaped Ag–TiO2 nanocomposites (NCs) were synthesized on the gram scale and the enhanced antibacterial properties of TiO2 in the presence of silver were examined. The formation of Ag–TiO2 NCs was analyzed through various characterization techniques. The cell viability experimental results demonstrated that the Ag–TiO2 NCs have good biocompatibility. The antibacterial activity of the prepared Ag–TiO2 NCs was tested against the Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) bacterial strains. The Ag–TiO2 NCs exhibited promising and superior antibacterial properties compared to TiO2 nanospheres as confirmed by the bacterial growth and inhibition zone. The improvement in the antibacterial activity was attributed to the synergistic effect of the hybrid nature of TiO2 nanoparticles in the presence of Ag.

Titanium dioxide nanoparticles: Recent progress in antimicrobial applications

“…Deshmukh et al (2018) obtained similar results by confirming the antimicrobial activity of TiO 2 with incorporated Ag NPs. Jaber et al (2020) found that Ag/TiO 2 nanoparticles exhibited promising and superior antibacterial properties compared with TiO 2 nanospheres, as confirmed by the bacterial growth and inhibition zone. Desiati et al (2019) concluded that the capability of TiO 2 /Ag NPs to kill bacteria depends on their structure and morphology, which are affected by their calcination temperature.…”

“…Studies investigating antimicrobial activity of TiO 2 NPs using disk diffusion method. References: [1] (Niranjan et al, 2019); [2] (Jaber et al, 2020); [3] (Pavlova et al, 2020); [4] (Saleh et al, 2019). …”

Preparation and properties of antibacterial biomaterial PAA/TiO2/Ag

“…The complex of titanium dioxide and silver nanoparticles have low toxicity to human cells and great antibacterial properties 22–24 . Jaber M et al prepared TiO 2 /Ag nanomaterials, and their experimental results demonstrated high biocompatibility and preferable antibacterial activity compared to TiO 2 nanospheres 25 …”

“…22-24 Jaber M et al prepared TiO 2 /Ag nanomaterials, and their experimental results demonstrated high biocompatibility and preferable antibacterial activity compared to TiO 2 nanospheres. 25 Polyamino acids (PAAs) are organic compounds that are structurally similar to natural proteins. PAAs exhibit good biocompatibility, and their degradation products are oligopeptides or small amino acid molecules, which are close to neutral and non-toxic.…”