Gram-Negative Folliculitis in Acne Vulgaris

Fulton, James E.; Leyden, James J.; Marples, R. R.

doi:10.1001/archderm.1968.01610160023005

Cited by 78 publications

(17 citation statements)

References 7 publications

(1 reference statement)

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“…This observation indicates that they probably occupy distinct niches within the follicular environment and therefore do not normally compete intergenerically. It also follows that a follicle favourable for the growth of one micro-organism is not necessarily favourable to the growth of another cutaneous group, although there is considerable evidence that when cutaneous genera are displaced from follicles by antimicrobial therapy, other groups (particularly enterobacteria) will sometimes fill the niches left unoccupied (Fulton et al, 1968). The physical and chemical parameters of pilosebaceous units are poorly defined because this environment is inaccessible to most investigative probes.…”

Section: Results a N D Discussionmentioning

confidence: 99%

The Microbial Ecology of Pilosebaceous Units Isolated from Human Skin

1984

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A method allowing isolation and microbiological analysis of individual pilosebaceous units (follicles) was used to study biopsies of back skin obtained from volunteer acne vulgaris patients. The main microbial groups isolated were members of the genera Propionibacterium, Staphylococcus and Pityrosporum. The incidence (and mean density) of these organisms in 140 normal follicles was 12% (2.6 x lo5 per follicle), 4% (5.5 x lo3 per follicle) and 13% (lo2 per follicle) respectively. Colonized follicles were not distributed evenly amongst the subjects studied. The results are analysed and discussed from an ecological standpoint.

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Section: Results a N D Discussionmentioning

confidence: 99%

The Microbial Ecology of Pilosebaceous Units Isolated from Human Skin

1984

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“…Long-term antibiotic treatment for acne has been associated with acquisition of antibiotic resistance. 24,25 Gram-negative folliculitis 26 and pharyngitis 27 are also associated with antibiotic therapy of acne, and likely are opportunistic infections resulting from disturbed microbial community ecology on the skin and in the airways, respectively.…”

Section: Sebaceous Skin: Acne and Rosaceamentioning

confidence: 99%

The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease

Grice¹

2014

Sem Cutan Med Surg

195

147

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A vast diversity of microorganisms, including bacteria, fungi, viruses, and arthropods, colonize the human skin. Culture-independent genomic approaches for identifying and characterizing microbial communities have provided glimpses into the topographical, temporal, and interpersonal complexity that defines the skin microbiome. Identification of changes associated with cutaneous disease, including acne, atopic dermatitis, rosacea, and psoriasis, are being established. In this review, our current knowledge of the skin microbiome in health and disease is discussed, with particular attention to potential opportunities to leverage the skin microbiome as a diagnostic, prognostic, and/or therapeutic tool.

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“…This is a follicular pyoderma and not a variant of acne, but it is a characteristic complication of long-term oral antibiotic acne treatment [23,24]. Gram-negative folliculitis occurs in patients who have had moderately inflammatory acne for long periods and have been treated with long-term antibiotics, especially tetracyclines.…”

Section: Gram-negative Folliculitismentioning

confidence: 99%

Acneiform Dermatoses

Plewig

Jansen

1998

Dermatology

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Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess. The earliest histological event is spongiosis, followed by a break in the follicular epithelium. The spilled follicular contents provokes a nonspecific lymphocytic and neutrophilic infiltrate. Acneiform eruptions are almost always drug induced. Important clues are sudden onset within days, widespread involvement, unusual locations (forearm, buttocks), occurrence beyond acne age, monomorphous lesions, sometimes signs of systemic drug toxicity with fever and malaise, clearing of inflammatory lesions after the drug is stopped, sometimes leaving secondary comedones. Other cutaneous eruptions that may superficially resemble acne vulgaris but that are not thought to be related to it etiologically are due to infection (e.g. gramnegative folliculitis) or unknown causes (e.g. acne necrotica or acne aestivalis). oooooooooooooooooooo

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Gram-Negative Folliculitis in Acne Vulgaris

Cited by 78 publications

References 7 publications

The Microbial Ecology of Pilosebaceous Units Isolated from Human Skin

The Microbial Ecology of Pilosebaceous Units Isolated from Human Skin

The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease

Acneiform Dermatoses

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