Grafting and Attachment of Antiplatelet Agents to Poly(Ether-Urethanes)

Routes to Bioactive Hydrophilic Polymers

“…19, No. 5,1987 tive when coupled to the polymer as side chains, in marked contrast to the behavior of BW 245C (Figure 1). We believe that these differences arise from contrasting steric requirements of the drug-receptor interactions.…”

“…4 Further, coinitiators were prepared by coupling (1) to 2,2,2-trichloroethanol (5) and 2-bromoethanol (6). …”

Modification of Biomaterials to Improve Blood Compatibility

“…We shall see later that as far as platelet adhesion is concerned, the compounds [14,15,16] confer a significant degree of passivity on polymer surfaces to which they are attached.…”

“…This represents a portion of the polymer chain; the proportions of BW 245C and vinyl monomer units are [5) [12] to the urethane linkages and used as free radical sources (with the aid of the metal carbonyl processes already outlined) (18,19) to graft on the BW 245C-monomer ( [5], n=1) and DI MA [11] and many other species. Interesting monomers [14], [15], have been prepared from several a-amino acids and also from amino sugars, e.g. glucamine, by reacting these compounds with [13].…”

“…3a). D-glucamine monomer [15] was grafted to Pellethane heterogeneously; a film of the resulting polymer showed no platelet adhesion (Fig. 3b).…”