Graft-copolymerization of methylacrylic acid onto hydroxypropyl chitosan

Xie, Wenming; Xu, Pengcheng; Qing, Liu; Xue, Jian

doi:10.1007/s00289-002-0076-1

Cited by 26 publications

(11 citation statements)

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“…The introduction of hydroxyethyl group enables it potential and attractive as absorbable biomaterial applied in vivo (Xie et al, 2002a;Liu et al, 2003). Previous studies suggest that lysozyme and chitinase are able to degrade chitosan, which is affected by many factors including water-solubility, degree of acetylation and molecular weight (Muzzarelli, 1997;Vårum et al, 1997;Mao et al, 2005;Dong et al, 2012).…”

Section: Discussionmentioning

confidence: 98%

“…Early studies have showed that HP-chitosan is a multifunctional water-soluble chitosan derivative once hydrophilic moiety to the OH groups at C-6 and C-3 and the NH 2 group of chitosan were introduced (Dong et al, 2001;Peng et al, 2005). Indeed, introduction of hydroxypropyl group to chitosan endow chitosan with new features like significant increase of solubility and moisturizing capability (Zhu et al, 2001;Wan et al, 2004;Peng et al, 2005), extending its applications as biomedical material, pharmaceutical excipient and bioactive reagent (Xie et al, 2002a;Liu et al, 2003;Prabaharan and Mano, 2005). Using HP-chitosan, Wang et al (2010) developed an efficient targeted delivery of antisense oligodeoxynucleotides, a potential approach to overcome tumor drug resistance.…”

Section: Introductionmentioning

confidence: 98%

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Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Shao

Han

Dong

et al. 2015

J. Ocean Univ. China

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Hydroxypropyl chitosan (HP-chitosan) has been shown to have promising applications in a wide range of areas due to its biocompatibility, biodegradability and various biological activities, especially in the biomedical and pharmaceutical fields. However, it is not yet known about its pharmacokinetics and biodegradation performance, which are crucial for its clinical applications. In order to lay a foundation for its further applications and exploitations, here we carried out fluorescence intensity and GPC analyses to determine the pharmacokinetics mode of fluorescein isothiocyanate-labeled HP-chitosan (FITC-HP-chitosan) and its biodegradability. The results showed that after intraperitoneal administration at a dose of 10 mg per rat, FITC-HP-chitosan could be absorbed rapidly and distributed to liver, kidney and spleen through blood. It was indicated that FITC-HP-chitosan could be utilized effectively, and 88.47% of the FITC-HP-chitosan could be excreted by urine within 11 days with a molecular weight less than 10 kDa. Moreover, our data indicated that there was an obvious degradation process occurred in liver (< 10 kDa at 24 h). In summary, HP-chitosan has excellent bioavailability and biodegradability, suggesting the potential applications of hydroxypropyl-modified chitosan as materials in drug delivery, tissue engineering and biomedical area.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Shao

Han

Dong

et al. 2015

J. Ocean Univ. China

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“…Chitosan (4.0 g) was mixed with NaOH solution (50% w/w, 40 mL) and allowed to swell at room temperature for 18 h. It was then incubated in a freezer 24 h at -18 o C for alkalization. 32 Alkali chitosan and isopropyl alcohol (40.0 mL) were transferred into a 250 mL round-bottomed flask and stirred for 1.0 h at 40 o C. After this period, 80 mL propylene oxide was added in the mixture, and refluxed 2 h at 60 o C with continuous stirring. The reaction mixture was adjusted to pH 7.0 with HCl solution.…”

Section: Methodsmentioning

confidence: 99%

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

et al. 2011

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This study examined the effects of the surface properties of the materials, such as the hydroxyl, methyl and amino groups, on rat bone marrow derived Mesenchymal Stem Cell (MSC) seeding. A series of hydrogels were prepared in film form using 2-hydroxyethyl methacrylate (pHEMA), poly(ethyleneglycol) methacrylate (PEG-MA), and/or hydroxypropyl-chitosan (HPC). The physicochemical properties of these hydrogel films, such as water content, functional groups, contact angle, surface energy and thermal properties were affected by the composition of the materials. The ability of the MSCs to form colonies, as well as their viability on these materials were also analyzed. The water content of the hydrogel films increased with increasing PEG-MA and HPC ratio in the hydrogel. Contact angle measurements of the surface of the hydrogel films demonstrated that all the materials gave rise to a significantly hydrophilic surface compared to pure pHEMA. The blood protein interactions and platelet adhesion were reduced significantly on the surface of the materials upon the incorporation of PEG-MA compared to the control pure pHEMA and vice versa for HPC. The ability of the MSCs to adhere and form colonies on these materials was also analyzed. The results showed that these materials are suitable candidates to isolate and expand MSCs.

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“…The advantage of using Chi‐PM is that the Chi is not fragmented under the influence of radicals generated, whereas radicals generated by PSA lead to decomposition of Chi chain. Copolymerization of Chi with other monomers is commonly initiated by PSA 19–21. This process is accompanied by degradation of Chi due to the cleavage of the C 1 C 4 bonds, making it difficult to obtain hydrogel 22…”

Section: Resultsmentioning

confidence: 99%

Peroxide‐Containing Chitosan Derivative for Hydrogel Synthesis

Solomko

Budishevska

Voronov

et al. 2010

Macromolecular Symposia

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Summary: Peroxide‐containing chitosan was synthesized using a polymer‐analogous reaction between chitosan and tert‐butylperoxymethyl ester of maleic acid. Peroxide‐containing chitosan macromolecules cross‐link into a polymeric hydrogel network in the presence of 1‐vinyl‐2‐pyrrolidone upon heating. Polymeric hydrogels are formed due to reactions of radical chain transfer and recombination. Reacting radical species are chitosan macroradicals and poly(vinylpyrrolidone) macroradicals formed by decomposition of peroxide‐containing fragments. Synthesized hydrogels are pH‐responsive and facilitate drug release.

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Graft-copolymerization of methylacrylic acid onto hydroxypropyl chitosan

Cited by 26 publications

References 0 publications

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Pharmacokinetics and biodegradation performance of a hydroxypropyl chitosan derivative

Preparation and characterization of poly(hydroxyethyl methacrylate-co -poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells

Peroxide‐Containing Chitosan Derivative for Hydrogel Synthesis

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