“…HA and zwitterionic polymers can bind numerous water molecules through physical interactions (hydrogen bonds, electrostatic interaction), and the three-dimensional network structure of hydrogels allows them to efficiently absorb and accommodate water. − Hence, HA and PCB hydrogels were used as hemostatic materials and chronic wound dressings for the management of wound exudate. − What’s more, HA can be degraded by hyaluronidase and reactive oxygen species (ROS), , which have been applied to the design of intelligent responsive drug delivery platforms. , Some reports also demonstrated that the degraded fragments of HA can stimulate cell cycle progression and promote angiogenesis, collagen tissue formation, and re-epithelialization in the healing process of wounds. , For these reasons, the water absorption capacity and degradation behaviors of HA-CB hydrogels were evaluated.…”
Section: Resultsmentioning
confidence: 99%
“…48−51 What's more, HA can be degraded by hyaluronidase and reactive oxygen species (ROS), 52,53 which have been applied to the design of intelligent responsive drug delivery platforms. 54,55 Some reports also demonstrated that the degraded fragments of HA can stimulate cell cycle progression and promote angiogenesis, collagen tissue formation, and re-epithelialization in the healing process of wounds. 3,56 For these reasons, the water absorption capacity and degradation behaviors of HA-CB hydrogels were evaluated.…”
Section: Water Absorption and Degradationmentioning
Hyaluronic acid and zwitterionic hydrogels are soft materials with poor mechanical properties. The unique structures and physiological properties make them attractive candidates for ideal hydrogel dressings, but the crux of lacking satisfying mechanical strengths and adhesive properties is still pendent. In this study, the physical cross-linking of dipole−dipole interactions of zwitterionic pairs was utilized to enhance the mechanical properties of hydrogels. The hydrogels have been prepared by copolymerizing methacrylate hyaluronic (HAGMA) with carboxybetaine methacrylamide (CBMAA) (the mass ratio of [HAGMA]/[CBMAA] is 2:5, 1:5, 1:10, or 1:20), obtaining HA-CB 2.5 , HA-CB 5.0 , HA-CB 10.0 , or HA-CB 20.0 hydrogel. Therein, the HA-CB 20.0 hydrogel with a high CBMAA content can generate a strong dipole−dipole interaction to form internal physical cross-links, exhibit stretchability and low elastic modulus, and withstand 99% compressive deformation and cyclic compression under strain at 90%. Moreover, the HA-CB 20.0 hydrogel is adhesive to diverse substrates, including skin, glass, stainless steel, and plastic. The synergistic effect of HAGMA and CBMAA shows strong antibiofouling, high water absorption, biodegradability under hyaluronidase, and biocompatibility.
“…HA and zwitterionic polymers can bind numerous water molecules through physical interactions (hydrogen bonds, electrostatic interaction), and the three-dimensional network structure of hydrogels allows them to efficiently absorb and accommodate water. − Hence, HA and PCB hydrogels were used as hemostatic materials and chronic wound dressings for the management of wound exudate. − What’s more, HA can be degraded by hyaluronidase and reactive oxygen species (ROS), , which have been applied to the design of intelligent responsive drug delivery platforms. , Some reports also demonstrated that the degraded fragments of HA can stimulate cell cycle progression and promote angiogenesis, collagen tissue formation, and re-epithelialization in the healing process of wounds. , For these reasons, the water absorption capacity and degradation behaviors of HA-CB hydrogels were evaluated.…”
Section: Resultsmentioning
confidence: 99%
“…48−51 What's more, HA can be degraded by hyaluronidase and reactive oxygen species (ROS), 52,53 which have been applied to the design of intelligent responsive drug delivery platforms. 54,55 Some reports also demonstrated that the degraded fragments of HA can stimulate cell cycle progression and promote angiogenesis, collagen tissue formation, and re-epithelialization in the healing process of wounds. 3,56 For these reasons, the water absorption capacity and degradation behaviors of HA-CB hydrogels were evaluated.…”
Section: Water Absorption and Degradationmentioning
Hyaluronic acid and zwitterionic hydrogels are soft materials with poor mechanical properties. The unique structures and physiological properties make them attractive candidates for ideal hydrogel dressings, but the crux of lacking satisfying mechanical strengths and adhesive properties is still pendent. In this study, the physical cross-linking of dipole−dipole interactions of zwitterionic pairs was utilized to enhance the mechanical properties of hydrogels. The hydrogels have been prepared by copolymerizing methacrylate hyaluronic (HAGMA) with carboxybetaine methacrylamide (CBMAA) (the mass ratio of [HAGMA]/[CBMAA] is 2:5, 1:5, 1:10, or 1:20), obtaining HA-CB 2.5 , HA-CB 5.0 , HA-CB 10.0 , or HA-CB 20.0 hydrogel. Therein, the HA-CB 20.0 hydrogel with a high CBMAA content can generate a strong dipole−dipole interaction to form internal physical cross-links, exhibit stretchability and low elastic modulus, and withstand 99% compressive deformation and cyclic compression under strain at 90%. Moreover, the HA-CB 20.0 hydrogel is adhesive to diverse substrates, including skin, glass, stainless steel, and plastic. The synergistic effect of HAGMA and CBMAA shows strong antibiofouling, high water absorption, biodegradability under hyaluronidase, and biocompatibility.
“…Liu et al. designed and prepared a hyaluronic acid/poly(ethylene glycol)/halogen-free imidazole polyionic liquid semi-interpenetrating polymer network hydrogel wound dressing via Diels-Alder (DA) click reaction [ 136 ]. The hydrogel killed E. coli and S. aureus within 2 h and exhibited a good inactivation ratio (>95%) ( Fig.…”
“…Skin damage is often caused by physical or chemical factors such as exercise, trauma, acid, and alkaline erosion in daily life. , Once the structural integrity and continuity of the skin tissue are disrupted, i.e., wound forms, the deeper tissues and organs that the skin protects are exposed to the external environment. Wound management has become a serious problem in current clinical practice, costing billions of dollars annually around the world. − Wound healing is a complex process that involves several factors to restore the wound’s barrier function, and good wound dressings are essential to offer a stable healing environment. − Although many wound dressings, including gauze, foam, sponge, and bandage, are commonly utilized in clinical practice, they generally cannot adequately address the multifaceted requirements of the complex wound healing process (e.g., providing a wet environment, excellent wound shape adaptation, etc. ). − Therefore, it is urgent to develop ideal wound dressings to meet the requirements of clinical wound therapy.…”
It is highly desired yet challenging to fabricate biocompatible injectable self-healing hydrogels with anti-bacterial adhesion properties for complex wounds that can autonomously adapt to different shapes and depths and can promote angiogenesis and dermal collagen synthesis for rapid wound healing. Herein, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed from a thermoresponsive ABA triblock copolymer poly[(N-isopropyl acrylamide)-co-(butyl acrylate)-co-(sulfobetaine methacrylate)]-b-poly(ethylene glycol)-b-poly[(N-isopropyl acrylamide)-co-(butyl acrylate)-co-(sulfobetaine methacrylate)] (PZOPZ). The prepared PZOPZ hydrogel exhibits a distinct thermal-induced sol−gel transition around physiological temperature and could be easily applied in a sol state and in situ gelled to adapt complex wounds of different shapes and depths for complete coverage. Meanwhile, the hydrogel possesses a rapid selfhealing ability and can recover autonomously from damage to maintain structural and functional integrity. In addition, the CCK-8 and 2D/3D cell culture experiments revealed that the PZOPZ hydrogel dressing shows low cytotoxicity to L929 cells and can effectively prevent the adhesion of Staphylococcus aureus and Escherichia coli. In vivo investigations verified that the PZOPZ hydrogel could increase angiogenesis and dermal collagen synthesis and shorten the transition from the inflammatory to the proliferative stage, thereby providing more favorable conditions for faster wound healing. Overall, this work provides a promising strategy to develop injectable zwitterionic hydrogel dressings with multiple functions for clinic wound management.
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