Recent progress of antibacterial hydrogels in wound dressings

Jia, Ben; Li, Guowei; Cao, Ertai; Luo, Jinlong; Zhao, Xin; Huang, Heyuan

doi:10.1016/j.mtbio.2023.100582

Cited by 100 publications

(58 citation statements)

References 265 publications

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“…The signals of H − in molecular chains of raw BIIR almost disappeared after the reaction with alkylimidazoles. The low signal intensities of H 4 and H 6 detected in the spectra of BIIR were assigned to allylic halide functionality. , Meanwhile, the new signals of H − indicated the successful grafting reaction of BI into BIIR molecular chains. , Owing to the aggregation behavior of ionic pairs, the formation of ionic clusters led to the creation of a dynamic ionic cross-linking network in the system (proved by the curing test in Figure S1).…”

Section: Results and Discussionmentioning

confidence: 96%

“…Moreover, since most wearable sensors directly contact human skin, there is a risk of bacteria breeding around the sensors due to sweat and body fluids. This creates an environment abundant in bacteria, which can lead to local inflammation and skin diseases . To address this concern, a wearable sensor must possess high stretchability and sensitivity to meet the requirements of human motion detection and a high antibacterial effect to improve wearing comfort.…”

Section: Introductionmentioning

confidence: 99%

“…This creates an environment abundant in bacteria, which can lead to local inflammation and skin diseases. 11 To address this concern, a wearable sensor must possess high stretchability and sensitivity to meet the requirements of human motion detection and a high antibacterial effect to improve wearing comfort. However, integrating these functions simultaneously remains challenging.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Dai

et al. 2023

ACS Appl. Polym. Mater.

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Flexible elastomer-based wearable sensors have gained tremendous attention due to their potential application in personal health diagnosis and human motion detection. However, challenges persist in achieving high sensitivity, stretchability, and antibacterial properties simultaneously. Herein, ionic crosslinked bromide butyl rubber (BIIR) filled with ionic liquid butylimidazole (BI)modified conductive carbon black (BCCB) is rationally designed and then fabricated into high-performance strain sensors by a facile solution mixing method. The BI not only ion-cross-linked the BIIR but also formed a strong interface between BIIR and conductive carbon black (CCB) through π−cation interactions, which facilitated the uniform dispersion of CCB throughout the BIIR matrix, leading to the formation of a conductive filler network. Based on the synergistic effect of the ionic cross-linking network and conductive filler network, the prepared BCCB/BIIR exhibited a low percolation threshold (1.75 wt %), high electrical conductivity (21.3 S/m), high tensile strength (4.9 MPa) and elongation at break >1200%, high sensitivity with gauge factor values of 9.41 at strains levels within 5% and 2048.89 at high strain levels, and excellent durability under cyclic working conditions. As a result, the BCCB/BIIR can be used as sensors for detecting both weak and large deformations induced by human activities, such as pulse, swallowing, and muscle and joint movements. Additionally, the sensor demonstrated over 99% antibacterial efficacy against Escherichia coli and Staphylococcus aureus, which can improve wearable comfort. The results suggest that the developed method provides a practical and large-scale production approach for fabricating high-performance sensors.

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Section: Results and Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Dai

et al. 2023

ACS Appl. Polym. Mater.

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“…Bacterial infection and inflammation are the main obstacles for the life‐threatening wounds with natural healing. [ 1‐3 ] The usage of antibiotics and traditional dressings such as gauzes and bandages is the widespread clinical management. [ 4 ] However, the long‐term use of antibiotics has brought a series of adverse effects including drug‐resistance and organ damage.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†

Wei,

Jia,

Wang

et al. 2023

Chin. J. Chem.

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Comprehensive SummarySupramolecular‐polymeric hybrid hydrogels combining advantages of the assembled supramolecular networks and polymeric networks have attracted considerable attention recently. However, they are rarely used as multi‐functional wound dressing materials. In this work, we report a supramolecular‐polymeric hybrid hydrogel consisting of a co‐assembled DBS‐COOH/Naproxen network (DBS/NAP) and a polymeric gelatin (G)/quaternary ammonium group (Q) and phenylboronic acid groups (PBA)‐grafted chitosan (QCS‐PBA) network (G/QCS) for accelerating skin wound healing. The polymeric networks could obviously enhance the mechanical properties of the drug‐derived supramolecular networks. Q groups endowed the hydrogel with enhanced antibacterial properties. Borate ester crosslinking between PBA groups and diol groups in DBS‐COOH could effectively scavenge reactive radicals. The hybrid hydrogel exhibited tunable mechanical and adhesive properties due to the temperature‐responsive gelatin networks. NAP could gradually release from hybrid hydrogel networks thus continuously relieving inflammation. Finally, the biocompatible, adhesive, antibacterial and antioxidant hybrid G/QCS‐DBS/NAP gel could promote the in vivo healing stages in a full‐thickness wounds with increased collagen deposition, upregulated CD31 expression and down‐regulated TNF‐α expression. Overall, this multi‐functional supramolecular‐polymeric hybrid hydrogel exhibited great potential for treating skin defects as promising wound dressing materials.

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“…6,7 Hydrogels are ideal for wound dressings because of their structural similarity to soft tissues, and they absorb wound exudate, act as a microbial barrier, maintain a relatively moist wound environment, allow oxygen penetration, and are excellent drug carriers for long-lasting controlled release of drugs, which can solve the problem of patients not being able to administer drugs at regular intervals. 8,9 Because of its strong adhesive properties and ease of controlled drug release after polyhydroxy gelling, polyvinyl alcohol (PVA) is a common material used in hydrogels. 10 Sarraf et al successfully bonded cracks in ceramic materials using a PVA/ethylenevinyl alcohol mixture.…”

Section: ■ Introductionmentioning

confidence: 99%

Efficient Photothermal, Flexible Wood-Based Hydrogel for Infected Wound Recovery

Liu

Song

et al. 2023

ACS Sustainable Chem. Eng.

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Photothermal therapy, because of its inherent high specificity and low invasiveness, can easily and quickly inhibit infected wounds and promote repair. Herein, flexible wood (LM) was synthesized and combined with clarithromycin-carrying black phosphorus in a polyvinyl alcohol matrix to create a highly effective photothermal and flexible wood-based hydrogel (LM@PBKb), which exhibited photothermal and photodynamic bactericidal effects as well as long-lasting wound sterility for the treatment of infected skin wounds. The LM@PBKb hydrogel exhibited a photothermal conversion efficiency of 28.8%. When 808 nm laser irradiation and the long-lasting sustained release of the LM@PBKb hydrogel were combined, Escherichia coli was almost completely inhibited. After 808 nm laser irradiation in the near-infrared region, LM@PBKb used in mice with infected wounds rapidly inhibited infection, maintained a sterile environment for a long time, and accelerated wound healing. Scanning electron microscopy images show that the wounds treated with LM@PBKb were relatively flat and resembled uninfected wounds. This highly efficient photothermal flexible wood-based hydrogel is a high-potential environmentally friendly biomaterial.

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Recent progress of antibacterial hydrogels in wound dressings

Cited by 100 publications

References 265 publications

Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†

Efficient Photothermal, Flexible Wood-Based Hydrogel for Infected Wound Recovery

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Recent progress of antibacterial hydrogels in wound dressings

Cited by 100 publications

References 265 publications

Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Enhanced Interface between Conductive Fillers and Elastomeric Ionomers for Highly Sensitive and Stretchable Strain Sensors toward Human Motion Detection

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair†

Efficient Photothermal, Flexible Wood-Based Hydrogel for Infected Wound Recovery

Contact Info

Product

Resources

About

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†