Grading of meningiomas

Sekhar, Laligam N.; Levine, Zachary T.; Sarma, Sailendra Nath

doi:10.1054/jocn.2001.0867

Cited by 22 publications

(5 citation statements)

References 10 publications

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“…However, the optimal management approach for postoperative radiation treatment, especially for WHO Grade I meningiomas, remains to be elucidated. 32,38 The Simpson grading system alone appears to be inconclusive with respect to this issue because the immediate necessity of radiation therapy for benign meningiomas after Simpson Grade I, II, or III resection is usually minimal. Several studies have advocated the use of proliferation markers such as the MIB-1 LI for anticipating tumor recurrence based on follow-up data from a relatively small number of patients, 3,4,13,14,23,26,40 whereas other studies have reported the limitations of such markers.…”

mentioning

confidence: 99%

Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas

Oya

Kawai²,

Nakatomi³

et al. 2012

JNS

192

136

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The clinical significance of the different management strategies related to Simpson Grade I-III resection may have been diluted in the modern surgical era. The MIB-1 index can differentiate tumors with a high risk of recurrence, which could be beneficial for planning tailored optimal follow-up strategies. The results of this study appear to provide a significant backing for the recent shift in meningioma surgery from attempting aggressive resection to valuing the quality of the patient's life.

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mentioning

confidence: 99%

Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas

Oya

Kawai²,

Nakatomi³

et al. 2012

JNS

192

136

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“…Imaging studies were used to assess the tumor's involvement with the ICA. The meningiomas were classified according to the classification of Sekhar et al 36 Thirty-four meningiomas corresponded to Grade I, 20 to Grade II, and 46 to Grade III. No meningioma had Grade IV ICA involvement.…”

Section: Tumor Classificationmentioning

confidence: 99%

Long-term follow-up of meningiomas of the cavernous sinus after surgical treatment alone

Sindou

Wydh²,

Jouanneau³

et al. 2007

JNS

111

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“…Further, other factors have also been implicated in tumour recurrence namely, incomplete surgical removal, high grade tumours, variable contrast enhancement seen radiologically, microscopy showing nucleolar prominence and evidence of 2 or more mitosis per 10 high power field. [44][45][46] This study showed that PTBE was significantly associated with several histological subtypes of meningiomas bearing high risk potential. In addition, PTBE was also found in all the cases of WHO grade II and grade III meningioma and a subgroup of WHO grade I meningiomas.…”

Section: Discussionmentioning

confidence: 70%

The role of peritumoural brain edema in ascertaining the high risk meningiomas

et al. 2020

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Background: Meningiomas are benign tumours which possess a potential to recur. Peritumoural brain edema (PTBE) has been associated with several complications and future recurrence. This study aims to establish the relation of PTBE in different histopathological grades and subtypes of meningiomas and in addition determines the significance of PTBE in ascertaining tumour recurrence. Methods: Complete surgical resection samples from 50 meningioma patients were obtained from the neurosurgical department and histopathologically processed. CT (computerised tomography) scans were used for ascertaining the tumour site and PTBE. Patients were followed up yearly for 4years. Recurrent cases were surgically resected and histologically typed.Results: Meningiomas were more common in the females (70%) than males (30%). PTBE was found in 56% of the cases. 62% were <50 years of age. No significant association was found between gender or age and PTBE. Cerebral convexity was the most common site (56%). 48.8% of grade I meningiomas (p<0.05) and 100% of grade II and grade III meningiomas showed PTBE. Yearly follow up for 4 years showed 10 cases to recur. 90% of these had evidence of PTBE on their pre-operative CT scans. These results were statistically significant (Z=11.31, p<0.001). Conclusions: Meningiomas are mostly benign entities. However, some histological subtypes possess a potential to recur and invade. It has been found that cases showing radiological evidence of PTBE are at a high risk. Hence, follow up of such cases is essential to improve patient survival.

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Grading of meningiomas

Cited by 22 publications

References 10 publications

Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas

Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas

Long-term follow-up of meningiomas of the cavernous sinus after surgical treatment alone

The role of peritumoural brain edema in ascertaining the high risk meningiomas

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