2010
DOI: 10.1097/aci.0b013e32833c148b
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GRADE system: new paradigm

Abstract: Evidence-based medicine requires integrating the best available 'benchmark' literature with patient preferences and values (bedside) and is an evaluation process involving both patient and clinician, with a systematic assessment of the rated evidence from state-of-the-art medical literature. The GRADE methodology was developed as an application of evidence-based medicine to the field of recommendations and their formulation. The GRADE working group brings together clinical researchers and methodologists who de… Show more

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Cited by 71 publications
(48 citation statements)
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“…We deliberately did not include an overall numeric rating of risk of study bias but, instead, made a judgment of the overall risk of study bias based on assessment of risk of bias of 10 individual items. This approach is consistent with the Cochrane and GRADE systems [3,22]. In addition, we have provided empirical evidence of its interrater agreement.…”
Section: Discussionmentioning
confidence: 60%
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“…We deliberately did not include an overall numeric rating of risk of study bias but, instead, made a judgment of the overall risk of study bias based on assessment of risk of bias of 10 individual items. This approach is consistent with the Cochrane and GRADE systems [3,22]. In addition, we have provided empirical evidence of its interrater agreement.…”
Section: Discussionmentioning
confidence: 60%
“…The summary assessment evaluates the overall risk of study bias and is based on the rater's subjective judgment given responses to the preceding 10 items. This is based on the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) and Cochrane approaches [3,22].…”
Section: Resultsmentioning
confidence: 99%
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“…If there is insufficient information in the article to permit judgement of a particular item, then the article is deemed to be at high risk of bias with respect to that item 1926 27GRADE, Grading of Recommendation, Assessment, Development and Evaluation; PRISMA, The Preferred Reporting Items for Systematic reviews and Meta-Analyses.…”
Section: Methods and Analysismentioning
confidence: 99%
“…El análisis de la evidencia según el sistema GRADE (The Grading of Recommendations Assessment, Development and Evaluation) establece fortalezas de recomendaciones terapéuticas más rigurosas. 11,34,35 Los objetivos del tratamiento de la tos cróni-ca consisten primariamente en eliminar el agente causal, promover la broncodilatación, movilizar las secreciones facilitando la expectoración y, en última instancia, suprimir la estimulación de receptores periféricos y deprimir el centro de la tos.…”
Section: Anamnesis Y Examen Físicounclassified