GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis

Chen, Jiawei; Cao, Qiang; Qin, Chao; Shao, Pengfei; Wu, Yilong; Wang, Meilin; Zhang, Zhengdong; Chen, Yin

doi:10.1007/s00432-011-1033-x

Cited by 23 publications

(17 citation statements)

References 51 publications

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“…The Asian population in our database had a zero T allele frequency, while the Maori and Pacific populations showed a frequency of 0.04, similar to that of Asian populations reported by Chen et al [20]. The Indian and Middle Eastern group had a T allele frequency of 0.25, which is within the range reported for Europeans [20]. Therefore, the current subject selection for the analysis was based on the GPx1 rs1050450 T allele frequency distribution (similar to that of Europeans reported by Chen et al) and included subjects self-reporting as Indian sub-continent and Middle Eastern origins, along with those reporting a European origin.…”

Section: Methodssupporting

confidence: 66%

“…It is possible that the increased GPx activity among GPx1 rs1050450 allele T is a feature dependent on the prostate cancer pathway. A meta-analysis carried out in 14,372 cases with different tumour types and 18,081 controls derived from 31 published case-control studies has indicated that individuals with GPx1 rs1050450 CT and TT genotypes are at high risk for overall cancer incidence [20]. …”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the database included 11 patients (1.3%) reporting a Maori and Pacific ethnicity, 6 patients (0.7%) of Asian and 13 (1.5%) of Indian/Middle Eastern ethnicities. According to a meta-analysis performed by Chen et al [20], Asian populations show a significantly lower mean frequency for minor allele T of GPx1 rs1050450 (0.06) compared to Europeans (0.30). The Asian population in our database had a zero T allele frequency, while the Maori and Pacific populations showed a frequency of 0.04, similar to that of Asian populations reported by Chen et al [20].…”

Section: Methodsmentioning

confidence: 99%

“…According to a meta-analysis performed by Chen et al [20], Asian populations show a significantly lower mean frequency for minor allele T of GPx1 rs1050450 (0.06) compared to Europeans (0.30). The Asian population in our database had a zero T allele frequency, while the Maori and Pacific populations showed a frequency of 0.04, similar to that of Asian populations reported by Chen et al [20]. The Indian and Middle Eastern group had a T allele frequency of 0.25, which is within the range reported for Europeans [20].…”

Section: Methodsmentioning

confidence: 99%

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Prostate Disease Risk Factors among a New Zealand Cohort

et al. 2012

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Background: Prostate cancer is a leading public health burden worldwide, and in New Zealand it is the most commonly registered cancer and the third leading cause of cancer deaths among males. Genetic variability and its associations with diet, demographic and lifestyle factors could influence the risk of this disease. Methods: The single nucleotide polymorphisms (SNPs) within a group of antioxidant genes and related markers were tested between patient and control cohorts, adjusted for significant differences between basic lifestyle and demographic characteristics. Results: Increasing age, smoking and low serum selenium levels were significantly associated with an increased risk for prostate disease. Alcohol consumption increased the glutathione peroxidase (GPx) activity. A significant reduction in alcohol consumption was recorded with prostate disease. Three SNPs, namely GPx1 rs1050450, SEL15 rs5845 and CAT rs1001179, were significantly associated with prostate disease risk. A cumulative risk of prostate cancer was noted with 6 risk alleles. A lower GPx activity was recorded with prostate disease compared to the controls. However, the GPx1 rs1050450 allele T in association with prostate cancer recorded a significantly higher GPx activity compared to the controls. Conclusions: These data point to a possibility of identifying individuals at risk of prostate cancer for better management purposes.

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Section: Methodssupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Prostate Disease Risk Factors among a New Zealand Cohort

et al. 2012

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“…The genetic study comprised the analysis of nine tag polymorphisms (http://www.broadinstitute.org/mpg/tagger/ server.html) of three genes of the enzymes of the ADS with the use of DNA real-time polymerase chain reaction (RT-PCR). These polymorphisms were selected, because it was shown that they are significant in other diseases, such as neoplasms, in which oxidative stress plays important role in etiopathogenesis [13]. Real-time PCR was performed using protocol provided by Applied Biosystem to assess rs1041740, rs4998557 and rs2070424 SNPs of the SOD1 gene, rs2855116, rs5746136 and rs4880 SNPs of the SOD2 gene and rs3448, rs1050450 and rs1800668 SNPs of the GPx-1 gene.…”

mentioning

confidence: 99%

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease

Spisak¹,

Klimkowicz-Mrowiec

Pera

et al. 2014

Neurologia i Neurochirurgia Polska

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Peptide or Protein‐Protected Metal Nanoclusters for Therapeutic Application

2021

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Comprehensive Summary Metal nanoclusters have attracted much attention due to their ultra‐small size and unique properties. The integration of protein or peptide can bring a synergistic effect on the physicochemical and physiological properties of metal clusters. Metal nanoclusters protected by peptides or proteins exhibit excellent biocompatibility and better disease therapeutic effects. We focus on developing new metal nanoclusters and exploring their therapeutic mechanism, including inhibiting enzyme activity, mitochondrial dysfunction, DNA strand break, and block of the signal pathway. What is the most favorite and original chemistry developed in your research group? The most favorite and original work we have done is the development of gold nanoclusters for diagnostic and therapeutic application. How do you get into this specific field? Could you please share some experiences with our readers? I have a great passion for research on bioanalytical imaging and the biomedical effects of nanomaterials, which may contribute to early diagnosis and treatment of diseases. My research is focused on exploring the mechanism of protein or peptide‐protected metal nanoclusters in disease diagnosis and treatment with the expectation of leading to superior therapeutic outcomes. What is the most important personality for scientific research? In my opinion, respect for originality, bold imagination, and innovation are the most important qualities of scientific research. What is your favorite journal(s)? My favorite journal is Nature Nanotechnology, where we can see the top and latest research progress on nanomaterials and learn about the superiority of nanomaterials and their potential for development. What are your hobbies? I love classical culture, poetry, the beauty of the mood. I also like history, and enjoy visiting historical places to appreciate the local customs. If you have anything else to tell our readers, please feel free to do so. I hope that people who have just started independent research work will not rush for quick success, plan your own direction systematically from the long‐term development. Never go flat, but keep "climbing".

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GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility: evidence from meta-analysis

Abstract: These results suggest that the GPx-1 Pro198Leo polymorphism contributes to cancer susceptibility through a disturbed antioxidant balance.

Cited by 23 publications

References 51 publications

Prostate Disease Risk Factors among a New Zealand Cohort

Prostate Disease Risk Factors among a New Zealand Cohort

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease

Peptide or Protein‐Protected Metal Nanoclusters for Therapeutic Application

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