GPR40 gene expression in human pancreas and insulinoma

Tomita, Tsutomu; Masuzaki, Hiroaki; Noguchi, Michio; Iwakura, Hiroshi; Fujikura, Junji; Tanaka, Tomohiro; Ebihara, Ken; Kawamura, Junichiro; Komoto, Izumi; Kawaguchi, Yoshiya; Fujimoto, Koji; Doi, Ryuichiro; Shimada, Yutaka; Hosoda, Kiminori; Imamura, Masayuki; Nakao, Kazuwa

doi:10.1016/j.bbrc.2005.10.161

Cited by 39 publications

(37 citation statements)

References 12 publications

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“…Previous attempts to detect expression of GPR40 in alpha-cells have been unfruitful, both using quantitative PCR on one human glucagonoma [13] and in situ hybridization combined with immunostaining for islet hormones in the rat pancreas [1,2]. The overall islet contribution of the different islet cell types varies among species.…”

Section: Discussionmentioning

confidence: 99%

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

Flodgren

Olde

Meidute-Abaraviciene

et al. 2007

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 99%

GPR40 is expressed in glucagon producing cells and affects glucagon secretion

Flodgren

Olde

Meidute-Abaraviciene

et al. 2007

Biochemical and Biophysical Research Communications

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“…There is a firm consensus that GPR40 is expressed in β-cells and this has been confirmed at the mRNA level in a range of species including mouse [23], rat [24] and man [25].…”

Section: Expression Of Gpr40mentioning

confidence: 90%

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell

Morgan¹,

Dhayal²

2009

Biochemical Pharmacology

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It is increasingly clear that some of the effects of both free and derivatised long chain fatty acids in pancreatic beta-cells are mediated by a group of G-protein coupled receptors. Some of these display close structural homology while others are more divergent. This Commentary reviews the expression and functional roles of three such molecules, GPR40, GPR119 and GPR120. GPR40 is the best characterised of this group and appears to mediate the acute stimulatory effects of long chain fatty acids on insulin secretion. GPR40 has also been proposed as a potential mediator of fatty acid toxicity but this is more controversial. GPR119 is also involved in stimulation of insulin secretion and responds primarily to ethanolamine derivatives of long chain fatty acids and also to some lysophospholipids rather than to free fatty acids. It may represent a useful target for the development of new insulin secretagogues aimed to enhance insulin release in patients with type 2 diabetes. GPR120 is the most enigmatic of the lipid responsive cell-surface receptors and its function remains to be established. It has been proposed to play a cytoprotective role in certain other cell types but it is unclear whether it fulfils a similar function in beta-cells.

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“…Moreover, FFA1 expression has been detected in various pancreas-derived cell lines, including MIN6, -TC-3, HIT-T15 and INS-1E (4,27,30,52). FFA1 expression has also been detected in human and rat islets (17,49,60). Outside of the pancreas, the presence of FFA1 mRNA has been reported in the small and large intestines (4,14,27) and in the STC-1 cells.…”

Section: Tissue Distribution Free Fatty Acid Receptor 1 (Ffa1)mentioning

confidence: 98%

“…In 2003, three groups independently reported that the FFA1 was an endogenous ligand for medium-and long-chain saturated and unsaturated fatty acids (4,27,30). Medium-and long-chain FFAs also activate GPR84 and GPR120 (24,60). On the other hand, SCFAs activate FFA2 (GPR43) and FFA3 (GPR41) (5,32,41).…”

Section: Free Fatty Acid Receptorsmentioning

confidence: 99%