Biochemical Pharmacology volume 78, issue 12, P1419-1427 2009 DOI: 10.1016/j.bcp.2009.07.020 View full text
Noel G. Morgan, Shalinee Dhayal

Abstract: AbstractIt is increasingly clear that some of the effects of both free and derivatised long chain fatty acids in pancreatic beta-cells are mediated by a group of G-protein coupled receptors. Some of these display close structural homology while others are more divergent. This Commentary reviews the expression and functional roles of three such molecules, GPR40, GPR119 and GPR120. GPR40 is the best characterised of this group and appears to mediate the acute stimulatory effects of long chain fatty acids on ins…

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