In the current globalized context, organizational capacity for change is a critical factor for companies to remain competitive. The purpose of this study was to conduct a quantitative analysis to measure the factors associated with Organizational Capacity for Change (OCC) in entities promoting business development in Antioquia, Colombia. To achieve this objective, a structural model comprising five dimensions was developed and validated, using confirmatory factor analysis through SPSS 28.0 software. The research instrument collected 250 survey responses from employees of three participating organizations in the study. The results obtained confirm that the proposed model is significant in explaining the studied phenomenon, as validation tests showed that the standardized factor loadings of all constructs were above 0.6, indicating their reliability. The study suggests that promoting creative development, organizational change, the perception of the need for change, participation, and commitment are essential elements for fostering OCC within companies. Optimizing communication spaces, conducting workshops to stimulate creativity, and encouraging employee involvement in initiatives can help mobilize organizations toward change. These findings provide evidence in favor of the proposed OCC model, which can serve as a reference for future studies, especially in adapting constructs and variables in specific contexts.