Gossypol Inhibits Testicular Steroidogenesis

Lin, T.; Murono, Eisuke P.; Osterman, Juraj; Nankin, Howard R.; Coulson, Patricia B.

doi:10.1097/00006254-198201000-00017

Cited by 15 publications

(24 citation statements)

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“…The results found in this study are in agreement with those previously informed [8], where the testicular incubation with precursors did not produce testosterone, even after stimulation with LH or AMPc, suggesting a blockade of the steroidogenesis. The serum androgen levels decreased in a similar fashion and the recovery after the experimental period was also comparable.…”

Section: Ansupporting

confidence: 93%

“…The existence of specific changes in quantity, motility, and structure of spermatozoa has been shown in studies performed in vivo, as well as in vitro [3,5,9,121. However, its effect on testicular steroidogenesis is still unclear, as neither changes in androgen levels [l, 101 nor diminution of plasmatic testosterone values, according to a dose-effect relationship and an unspecific blockade in the steroidogenic pathways, has been demonstrated [8]. Gossypol was used in these studies either in its gossypol-acetic acid or its pure forms.…”

Section: Introductionmentioning

confidence: 99%

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Cottonseed Flour Effects on Androgen Testicular Content and Serum Levels in Rats

Herrera¹,

Montalvo²,

González‐Garza³

et al. 1983

Archives of Andrology

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Natural gossypol present in the whole cottonseed flour (CSF) has clear antifertility properties, decreasing the number and motility of spermatozoa. In this study the endocrine function of the testes was evaluated, measuring by specific radioimmunoassays the testicular content and the serum levels of androstenedione (A), testosterone (T). and Sa-dihydrotestosterone in male rats fed with different and nontoxic concentrations of CSF along with Purina chow for 4 weeks, followed by 6 weeks of a recovery period. The testicular content of A, T, and DHT decreased 63%, 90%, and 38%, respectively, in comparison with their control. The serum levels of the three androgens diminished as follows: A 74%, T 95%, and DHT 60%. All the steroids measured in the recovery period showed a tendency towards the control values in both testicular content and serum. The most affected steroid was testosterone, which, after the recovery period, did not reach the control values. A also decreased, suggesting a blockade in testicular steroidogenesis caused by the initial diet.

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Section: Ansupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Cottonseed Flour Effects on Androgen Testicular Content and Serum Levels in Rats

Herrera¹,

Montalvo²,

González‐Garza³

et al. 1983

Archives of Andrology

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“…However, there are several reasons to evoke the hypothesis that the Leydig and Sertoli control mechanisms might be disturbed. It is known that, in vitro, gossypol induces a decrease in Leydig (Lin et al, 1981) and Sertoli (Oko & Hrudka, 1984) functions. In fact our results prove that, in vivo, after 34 days of treatment there is no Sertoli deficiency: the level of ABP, which assures the transport of androgens in the epididymal lumen, is not modified and the production of testicular fluid, which is a further index of Sertoli function (Hagenäs & Ritzen, 1976;Jegou et al, 1983), is also normal as it has previously been reported (Wong et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa

Soufir¹,

Radigue²,

Dantec³

et al. 1989

Reproduction

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Summary. Gossypol acetic acid (20, 25 or 30 mg/kg/day orally for 5 weeks) decreased epididymal weight in adult Sprague\p=n-\Dawley rats but the epididymal concentrations of proteins, lactate dehydrogenase and acid phosphatase were unchanged. The concentrations of carnitine, inositol and potassium in epididymal fluid were decreased in a dose-related manner. These modifications were not due to disturbances of Leydig and Sertoli cell functions which were normal. We suggest that the reduction in epididymal secretion results from a decrease in the number of spermatozoa rather than from a direct action of gossypol on the epididymal epithelium.

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“…1984. Lin et al [1981] reported a decrease in serum levels of testosterone and luteinizing hormone (LH). while Hahn et al [1981] and Wang et al [1984] showed that gossypol has no effect on the levels of circulat ing androgens in rodents.…”

Section: Discussionmentioning

confidence: 99%

Structural Changes of the Guinea Pig Prostatic Epithelial Cells after Gossypol Treatment

Yc¹,

Cc²

1989

Cells Tissues Organs

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The effect of gossypol acetic acid on the prostate gland of the guinea pig was assessed ultrastructurally. The three lobes of the gland showed differences in sensitivity and reacted differently to gossypol treatment. In the lateral prostate, there was a reduction in the profile of the granular endoplasmic reticulum and dense secretory granules with a concurrent appearance of smaller clear granules and an increase in cytoplasmic filamentous bundles. The latter feature was similar to that of the coagulating gland. In the dorsal prostate, the general reaction was similar to that in the lateral prostate except that there was no increase in filamentous content. In the coagulating gland, there was a reduction or total disappearance of apical secretory blebs and an increase in lysosomes, a feature not found in the lateral and dorsal lobes. Damages to mitochondria were observed in the dorsal prostate and coagulating gland but not in the lateral prostate. It is concluded that gossypol affects not only the testis, but also alters the structure and functions of the prostate gland.

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Gossypol Inhibits Testicular Steroidogenesis

Cited by 15 publications

References 0 publications

Cottonseed Flour Effects on Androgen Testicular Content and Serum Levels in Rats

Cottonseed Flour Effects on Androgen Testicular Content and Serum Levels in Rats

Gossypol-induced modifications in the microenvironment of rat epididymal spermatozoa

Structural Changes of the Guinea Pig Prostatic Epithelial Cells after Gossypol Treatment

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