Goodness-of-Fit Model-Dependent Approach for Release Kinetics of Levofloxacin Hemihydrates Floating Tablet

Thakkar, Vaishali; Shah, P. A.; Soni, Tejal; Parmar, M. Y.; Gohel, Mukesh C.; Gandhi, Tejal

doi:10.14227/dt160109p35

Cited by 38 publications

(25 citation statements)

References 20 publications

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“…In the present study, an attempt was made to design Carbidopa and Levodopa ER Tablet and its release profile was interpreted with various mathematical models [4].…”

Section: Formulation Of Carbidopa-levodopa Er Tablets 50 Mg/200 Mg [3]mentioning

confidence: 99%

Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets

Baishya¹

2017

J Dev Drugs

209

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The aim of present work is to determine and analyse the kinetics of drug release from the matrix tablet by employing various mathematical models. A study was done with Carbidopa and Levodopa ER tablets, 50 mg/200 mg by employing wet granulation technique using Hydroxypropyl methylcellulose and Hydroxypropyl cellulose as matrix forming polymer. The in-vitro drug release profile was carried out in 0.1 N HCl (900 mL) using USP dissolution apparatus II (Paddle) at 50 rpm at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained,

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“…In the present study, an attempt was made to design Carbidopa and Levodopa ER Tablet and its release profile was interpreted with various mathematical models [4].…”

Section: Formulation Of Carbidopa-levodopa Er Tablets 50 Mg/200 Mg [3]mentioning

confidence: 99%

Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets

Baishya¹

2017

J Dev Drugs

209

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“…In contrast to most conventional floating systems (including gas-generating ones), these minitablets floated immediately upon contact with the release medium showing zero lag time in floating behavior because the low density was prevailed from the beginning (t ¼ 0). Thakkar et al (2009) reported that in case of a gelucire based floating tablet, incorporation of HPMC and sodium bicarbonate is essential to achieve desirable floating. But in the present research, we have achieved desirable floating without any gas generating agent by compressing these gelucire-based granules into minitablets of 3 mm diameter but when the same formulation was compressed into a tablet of 6 mm diameter they did not exhibit floating.…”

Section: In Vitro Buoyancy and Percent Buoyancymentioning

confidence: 99%

Design and characterization of cefuroxime axetil biphasic floating minitablets

et al. 2014

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Biphasic floating minitablets of cefuroxime axetil were prepared by melt granulation technique using two different grades of gelucire namely 50/13 and 43/01 to maintain constant plasma drug concentration. Loading dose of cefuroxime axetil was formulated as immediate release (IR) minitablets by using hydrophilic grade of gelucire 50/13. Maintenance dose was formulated as floating sustained release (SR) minitablets by using hydrophobic grade of gelucire 43/01. The prepared IR and SR granules were subjected to micromeritic studies and scanning electron microscopy. Fourier transform infrared spectroscopy (FT-IR) study revealed that drug and selected carriers were compatible. In vitro dissolution study of optimized IR minitablets showed more than 85% of loading dose dissolved within 30 min. Optimized SR minitablets showed zero lag time with floating duration more than 12 h. The drug release from SR minitablets was linear with square root of time with non-Fickian diffusion-controlled release. The optimized batch of minitablets was filled into 0 size hard gelatin capsule. In vitro dissolution study for capsule showed an immediate burst release followed by SR up to 12 h. There is no significant change in dissolution data after storage at 40 C and 75% RH for three months. Microbiological assay of dissolution samples of optimized minitablets filled in capsules showed proportionate increase in inhibition of growth against Escherichia coli up to 12 h samples. In vivo bioavailability study in albino rabbits showed three times improvement in oral bioavailability.

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“…Media disolusi yang digunakan adalah larutan HCl 0,1 N sebanyak 900 ml pada suhu 37±0,5ºC [8]. Sampel (5,0 ml) diambil setiap interval waktu 10, 20, 30, dan 45 menit kemudian disaring dengan kertas saring 0,45 µm.…”

Section: Evaluasi Tabletunclassified

Optimasi Tablet Levofloksasin yang Mengandung Bahan Pengikat PVP K-30 dan Disintegran Vivasol

2017

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ABSTRACT:The aim of this research was to get optimal formula of levofloxacin tablet prepared with variation of PVP K-30 as binder and vivasol as disintegrant. The making of levofloxacin tablets was done by wet granulation. Tablet was prepared with various levels of PVP K-30 and disintegrant vivasol, compressed using a hydraulic press with 12 mm punch diameter, for 3 seconds. Physical quality (hardness, friability, and disintegration time) and dissolution rate of tablet was evaluated. The optimization of the formula was done by factorial design of 22 factorial experiments with 2 factors (PVP K-30 and vivasol) and 2 levels (2% and 4%). Optimization results showed that elevated levels of PVP K-30 increased tablet hardness, reduced friability of tablet, decreased disintegrating time, and increased dissolution rate of levofloxacin tablets. Meanwhile, elevated levels of vivasol increased the hardness of tablets, decreased the disintegrating time of tablets, decreased the dissolution rate of levofloxacin tablets, but did not affect the friability of tablets. In conclusion, the optimal tablet that meet the specifications of physical quality (hardness, friability, and disintegrating time) and dissolution rate was made by 2.4 to 3.7% of PVP K-30 and 2.0 to 3.2% vivasol as shown in the feasible area of design space. ABSTRAK:Penelitian ini bertujuan mendapatkan formula yang optimal tablet levofloksasin yang dibuat dengan variasi PVP K-30 sebagai pengikat dan vivasol sebagai disintegran. Metode pembuatan tablet levofloksasin dilakukan secara granulasi basah. Formula tablet dibuat dengan variasi PVP K-30 dan disintegran vivasol, dikempa menggunakan alat hidrolik press dengan puch diameter 12 mm, selama 3 detik. Evaluasi mutu fisik (kekerasan, kerapuhan, dan waktu hancur) dan laju disolusi tablet. Optimasi formula dilakukan dengan desain faktorial 22 yaitu eksperimen faktorial dengan 2 faktor (PVP K-30 dan vivasol) dan 2 level (2% dan 4%). Hasil optimasi menunjukkan bahwa peningkatan kadar PVP K-30 meningkatkan kekerasan tablet, menurunkan kerapuhan tablet, dan menurunkan waktu hancur tablet, serta meningkatkan laju disolusi dari tablet levofloksasin. Peningkatan kadar vivasol meningkatkan kekerasan tablet, tidak mempengaruhi kerapuhan tablet, dan menurunkan waktu hancur tablet, serta menurunkan laju disolusi tablet levofloksasin. Kesimpulan penelitian ini menunjukkan bahwa tablet yang optimal serta memenuhi spesifikasi dari mutu fisik (kekerasan, kerapuhan, dan waktu hancur) dan laju disolusi ditunjukkan pada daerah feasible dari design space yaitu kadar PVP K-30 antara 2,4 sampai 3,7 % dan kadar vivasol 2,0 sampai 3,2%.

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Goodness-of-Fit Model-Dependent Approach for Release Kinetics of Levofloxacin Hemihydrates Floating Tablet

Cited by 38 publications

References 20 publications

Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets

Application of Mathematical Models in Drug Release Kinetics of Carbidopa and Levodopa ER Tablets

Design and characterization of cefuroxime axetil biphasic floating minitablets

Optimasi Tablet Levofloksasin yang Mengandung Bahan Pengikat PVP K-30 dan Disintegran Vivasol

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