Design and characterization of cefuroxime axetil biphasic floating minitablets

Jammula, Sruti; Patra, Chinam Niranjan; Swain, Sanjit Kumar; Panigrahi, Kahnu Charan; Nayak, Smita; Dinda, Subas Chandra; Rao, Muddana Eswara Bhanoji

doi:10.3109/10717544.2013.871603

Cited by 19 publications

(11 citation statements)

References 31 publications

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“…The exact reasons for these findings cannot fully be delineated by the present study, but the complex nature of the meals (in which one should consider such variables as volume, mixture of solids and liquids, pH, osmolality and gastric pH on cefuroxime axetil absorption) might impact on gastric pH and emptying, hepatic extraction, and renal excretion, all of which could alter the pharmacokinetics of cefuroxime axetil [12][13][14] . The development of food-drug interactions may also depend on the size and the composition of a meal as well as the exact timing of drug intake in relation to a meal [15] .…”

Section: Male Subjects (N=17 Mean±sd) Female Subjects (N=6 Mean±sd)mentioning

confidence: 82%

Diet-induced Alterations in Pharmacokinetics of Cefuroxime Axetil in Healthy Chinese Subjects

Wang¹,

Fan²,

Cheng³

et al. 2019

ijps

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Wang et al.: Diet-induced Alterations in Pharmacokinetics of Cefuroxime Axetil This study was conducted to evaluate the pharmacokinetics, safety and gender difference of cefuroxime axetil after single dose administration under fasting and fed conditions in healthy Chinese male and female subjects. In an open-label, two-period study, 26 subjects received a single 250 mg oral dose with or without food. Blood samples were collected at scheduled time points till 24 h after drug administration and cefuroxime axetil concentration in blood was analysed using liquid chromatography with tandem mass spectrometry. Twenty-three subjects completed the study. Under fed state, the median time to peak plasma concentration of cefuroxime axetil was delayed by approximately 0.5 h compared with fasting state (2.23 h vs. 3.01 h) and there was a 43.9 % increase in the total systemic exposure (AUC0-∞) and 8.3, 38.7, 34.1 % reduction in elimination half-life, apparent volume of distribution and apparent clearance, respectively. No significant difference presented in maximum concentration achieved (p>0.05). There was no gender difference in pharmacokinetics and no serious adverse events reported, as well. This study indicated that the extent of absorption of cefuroxime axetil is significantly increased under fed state and it is recommended to be administrated after a meal.

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Section: Male Subjects (N=17 Mean±sd) Female Subjects (N=6 Mean±sd)mentioning

confidence: 82%

Diet-induced Alterations in Pharmacokinetics of Cefuroxime Axetil in Healthy Chinese Subjects

Wang¹,

Fan²,

Cheng³

et al. 2019

ijps

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“…# 40. The resultant granules were compressed into 3-mm circular minitablets and were filled into a gelatine capsule of size '0' [17].…”

Section: Preparation Of Fmm Of Nimodipinementioning

confidence: 99%

Formulation and development of floating multiple-unit minitablets of Nimodipine without using a gas-generating agent: in vitro and in vivo characterization

et al. 2020

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Background: Floating drug delivery systems have been reported for different active pharmaceutical ingredients as single-unit tablets with gas-generating agents. In this present research, the formulation of floating multiple-unit minitablets of Nimodipine without using gas-generating agent was attempted with an objective of increased residence time, sustain-release and improved oral bioavailability. Solid dispersion with different ratios (1:0.5, 1:1, 1: 1.5, 1:2, 1:2.5) of drug with the lipophilic carrier such as Compritol ATO 888, Gelucire 43/01, G39/01 and Precirol ATO 05 was formulated using melt granulation technique. The adsorbent Sylysia 350 to lipophilic carrier is maintained at 1:1. The granules were compressed into minitablets weighing 15 mg and were filled into a '0' size capsule.Results: Differential scanning calorimetry study justified no interaction of the drug with excipients. The formulations which exhibited desirable flow property, floating lag time less than 1 min and floating time of 12 h were further characterized for various post-compression parameters. The optimized single-dose (capsule) of floating multiple-unit minitablets of Nimodipine consisting of 60 mg of drug, 120 mg of G43/01 and 120 mg of Sylysia 350 showed an average of floating lag time within 24.48 s, floating time of 14.32 h and sustained-release up to 12 h. Pharmacokinetic study of the optimized formulation (F9) showed nearly 2.5 times increase in area under the curve with increased residence time in comparison to aqueous suspension of Nimodipine. The stability study revealed no significant change in various parameters before and after storage.Conclusion: Hence, gelucire 43/01-based multiple-unit minitablets of Nimodipine can be considered a promising approach for sustaining the drug release with gastric retention for 12 h without using gas-generating agent.

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“…because of substance official of medication to polymer framework, which was debased by compounds discharged from colonic small scale flora and in this manner discharged the medication. 26…”

Section: In-vivo Studies Git Distribution Studymentioning

confidence: 99%

Formulation and In vitro Characterization of Metronidazole Loaded Polymeric Microspheres for Colon Specific and Sustained Drug Delivery

Kar¹,

Dinda²

2019

PHM

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Objective: Metronidazole stacked alginate microspheres have been utilized to drag out the gastric living arrangement time and enhance the neighbourhood impact of medication in the district of colon for the treatment of bacterial contaminations by expecting that the colonic microbes will enzymatically corrupt the polysaccharide into natural corrosive and by bringing down the pH condition with the goal that disintegration of corrosive dissolvable covering and arrival of medication occur at the same time. Methods: Metronidazole microspheres were made by ionic gelation method utilizing Guargum, Chitosan, Eudragit S-100 and sodium alginate at various proportions and utilized calcium chloride (4% w/v) as rigidizing operator. Microspheres were described for its molecule measure, medicate stacking, tranquilize capture, swelling file and medication discharge properties. Results: Microspheres are observed to be inside size extents from 36.77µm to 229.96µm with medication capture proficiency of 42-99% w/w. The microsphere kept up to maintain the medication discharge up to 12 h if there should be an occurrence of definition FG4. Medication discharge from the microspheres, swelling file and lightness establishes to be relies upon the grouping of chosen polymers in the polymer mixture. Definitions containing low groupings of Guargum, Chitosan, Eudragit S-100 and sodium alginate (1:1) demonstrating shorter drifting slack time and quicker medication discharge and the other way around. Accordingly, swelling record and rate of medication discharge seemed, by all accounts, to be balanced by the centralization of chose polymers in the polymer mix. The outcomes demonstrated that Glutaraldehyde (1ml) based upgraded plan FG4 could be helpful in the detailing of metronidazole microspheres for better treatment of bacterial contaminations in colon.

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Design and characterization of cefuroxime axetil biphasic floating minitablets

Cited by 19 publications

References 31 publications

Diet-induced Alterations in Pharmacokinetics of Cefuroxime Axetil in Healthy Chinese Subjects

Diet-induced Alterations in Pharmacokinetics of Cefuroxime Axetil in Healthy Chinese Subjects

Formulation and development of floating multiple-unit minitablets of Nimodipine without using a gas-generating agent: in vitro and in vivo characterization

Formulation and In vitro Characterization of Metronidazole Loaded Polymeric Microspheres for Colon Specific and Sustained Drug Delivery

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