“…Mechanical itch is also a widespread phenomenon associated with many skin, systemic, neurological, and psychiatric diseases (Misery et al, 2018;Mollanazar et al, 2016;Wahlgren et al, 1991;Yosipovitch and Bernhard, 2013). However, in healthy humans, it has only been unequivocally induced under laboratory experimental conditions (Fukuoka et al, 2013;Ikoma et al, 2005) or under high-intensity vibration (Mueller et al, 2019). Thus, identifying and understanding the neural circuits mediating itch responses to mechanical stimuli remain challenges.…”