Good practice guide for cervical ultrasound scan and echo-guided techniques in treating differentiated thyroid cancer of vesicular origin

Leenhardt, Laurence; Borson‐Chazot, Françoise; Calzada, M.; Carnaille, B.; Charrié, Anne; Cochand‐Priollet, Béatrix; Cao, Christine Do; Leboulleux, Sophie; Clech, G. Le; Mansour, George; Ménégaux, Fabrice; Monpeyssen, Hervé; Orgiazzi, J; Rouxel, A.; Sadoul, Jean‐Louis; Schlumberger, Martin; Tramalloni, Jean; Tranquart, F.; Wémeau, Jean-Louis

doi:10.1016/j.ando.2011.04.001

Cited by 27 publications

(43 citation statements)

References 99 publications

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“…Kim et al (2009) tested different threshold and propose a combination: the threshold values for FNA-Tg levels should be >10ng/ml if the serum Tg level or the mean plus two standard deviation in node-negative patients is not available for reference. Finally the French consensus (Leenhardt et al, 2011) recommends: Tg <1ng/FNA: normal result, Tg between 1 and 10 ng/FNA: to be compared with the results from cytology and Tg> 10 ng/FNA: suggest the presence of tumoral tissue.…”

Section: The Results and Interpretationmentioning

confidence: 99%

“…An explanation of this could be that the excessive high concentration of Tg is able to saturate TgAb binding sites. So it is not recommended to assay TgAb in the rinsing liquid (Leenhardt et al, 2011).…”

Section: The Tg Methodsmentioning

confidence: 99%

“…We think that it is much better to use the Tgfree medium of the test kit to avoid bias in the determination of thyroglobulin in FNA wash samples (Bournaud et al, 2010). But for practical use the saline solution is often used and so it is recommended in the French good practice guide for cervical ultrasound scan and echoguided techniques (Leenhardt et al, 2011) to check for the absence of matrix effect in the usual assay method. It is possible to validate the use of saline solution by comparing the results of Tg immunoreactivity obtained with Tg-free solution, saline solution and saline solution supplemented with serum albumin (Borel et al, 2008).…”

Section: The Middlementioning

confidence: 99%

“…At present this very low functional sensitivity for certain cases of dosages could allow to replace rhTSH stimulated Tg testing for the patients at low risk by a simple dosage of second generation Tg. Low risk patients are those with well-differentiated papillary or follicular thyroid cancer, patient age <45 years, thyroid tumor size ranging from 1 cm to <4 cm in diameter, no extension of the tumor beyond the thyroid capsule, no lymph-node involvement and no distant metastases (Schlumberger et al, 2007;Smallridge et al, 2007;Schlumberger et al, 2011).…”

Section: Functional Sensitivitymentioning

confidence: 99%

“…Borel et al (2008) shows that a triple pumping action of the 1 mL liquid through the needle was sufficient to wash out 97% of Tg out of the needle. If the needle has to be inserted several times into the same lymph node, the needle rinse can be poured into the same tube (Leenhardt et al, 2011).…”

Section: The Volumementioning

confidence: 99%

See 4 more Smart Citations

The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer

Charrié¹

2012

Thyroid and Parathyroid Diseases - New Insights Into Some Old and Some New Issues

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Section: The Results and Interpretationmentioning

confidence: 99%

Section: The Tg Methodsmentioning

confidence: 99%

Section: The Middlementioning

confidence: 99%

Section: Functional Sensitivitymentioning

confidence: 99%

Section: The Volumementioning

confidence: 99%

See 3 more Smart Citations

The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer

Charrié¹

2012

Thyroid and Parathyroid Diseases - New Insights Into Some Old and Some New Issues

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Clinical application of the ultrasound‐guided fine needle aspiration for thyroglobulin measurement to diagnose lymph node metastasis from differentiated thyroid carcinoma‐literature review

Jiang

Hsiao

2020

The Kaohsiung J of Med Scie

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Papillary thyroid carcinoma (PTC) generally has a good prognosis, but disease recurs in 25% to 30% of PTC patients and significantly reduces the survival rate. Lymph node metastasis (LNM) is reported in 20% to 50% of PTC patients, mainly in the neck, and 20% originates from recurrence. LNM of papillary thyroid carcinoma are a plausible prognostic factor to determine disease recurrence. Currently, fine needle lymph node aspiration for cytology (LN‐FN‐cytology) is the best modality to diagnose LNM but is limited by diagnostic sensitivity and sample error. Fine needle lymph node aspiration for thyroglobulin measurement (LN‐FNA‐Tg) could offer a reliable and quantitative diagnostic method for LNM. The combination of LN‐FNA‐cytology and LN‐FNA‐Tg could achieve almost 100% diagnostic sensitivity and specificity for LNM. Both treatment guidelines of the American Thyroid Association and European Thyroid Association recommend LN‐FNA‐Tg to diagnose LNM after total thyroidectomy. Diagnostic accuracy of the LN‐FNA‐Tg depends on optimal equipment, scanning protocol, skill, and experience of operators. Normal saline is mainly used for aspiration needle wash‐out and buffer solution. And radioimmunoassay or immunoradiometric assay are widely used for the LN‐FNA‐Tg measurement. So far, there is no consensus about the diagnostic threshold of LN‐FNA‐Tg for positive LNM, but high LN‐FNA‐Tg, especially higher than 10 ng/mL, strongly favors LNM.

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Incidental thyroid papillary microcarcinoma: survival and follow‐up

Gorostis¹,

Raguin²,

Schneegans³

et al. 2019

The Laryngoscope

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Objectives/Hypothesis: The aim was to study the survival of incidental thyroid papillary microcarcinoma patients treated with surgery for benign thyroid disease to validate absence of oncological follow-up and reduce unnecessary health expenses.Study Design: Retrospective cohort study. Methods: We analyzed patient's files and interviewed 252 patients by telephone whose cases were submitted to the multidisciplinary meeting of thyroid pathology in Strasbourg, France, for incidental thyroid papillary microcarcinoma without clinical lymph node involvement, between January 1996 and December 2012.Results: Thirteen patients (5.8%) died while the data were being collected; however, none of the deaths were due to the thyroid pathology, and no patients showed signs of relapse of the thyroidectomy or cervical lymph node level.Conclusions: Our retrospective study shows that patients with incidental localized thyroid papillary microcarcinoma who underwent surgery without radioactive iodine treatment have an identical survival compared to the general population at the same age to validate absence of oncological follow-up and reduce unnecessary health expenses.

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Good practice guide for cervical ultrasound scan and echo-guided techniques in treating differentiated thyroid cancer of vesicular origin

Cited by 27 publications

References 99 publications

The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer

The Thyroglobulin: A Technically Challenging Assay for a Marker of Choice During the Follow-Up of Differentiated Thyroid Cancer

Clinical application of the ultrasound‐guided fine needle aspiration for thyroglobulin measurement to diagnose lymph node metastasis from differentiated thyroid carcinoma‐literature review

Incidental thyroid papillary microcarcinoma: survival and follow‐up

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