Using an assay with a lower functional sensitivity may give an earlier indication of the presence of Tg in the serum on L-T4 treatment and may be used to study the trend in serum Tg without performing any TSH stimulation. Serum Tg determination obtained after TSH stimulation still permits a more reliable assessment of cure and patient's reassurance.

A promising technique capable of performing localized resistance measurements over a surface is presented using a modified commercial atomic force microscope with a conducting probe. Its overall purpose is to obtain simultaneous cartographies of surface roughness and local resistance within a given microscopic area of a sample with nanometer scale resolution. Although an elaboration of suitable probes remains an ongoing problem, convincing images of some metal surfaces that reveal occasionally surprising features have already been obtained. Calculations performed from measurements have allowed us to clarify the mechanical nature of the tip/surface nanocontact and hence to determine the most probable transport process according to the range of resistance considered.