Good Nutritional Oral Intake Is Associated with Equal Survival in Demented and Nondemented Very Old Patients

Franzoni, Simone; Frisoni, Giovanni B.; Boffelli, Stefano; Rozzini, Renzo; Trabucchi, Marco

doi:10.1111/j.1532-5415.1996.tb01409.x

Cited by 63 publications

(33 citation statements)

References 28 publications

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“…In this population, neoplasias were the main determinants of mortality, particularly in the women, whereas the neurodegenerative diseases had a controversial protective effect because dementia is considered a strong predictor of mortality in the elderly (Guehne et al 2005), also regardless of APOE genotype (Little et al 2009). Although, a study reported that dementia developing in very old age is not necessarily associated with decreased life expectancy (Franzoni et al 1996), in our study population, the low mortality risk for this condition could be due to the short time of the follow-up. Further studies are needed to clarify the role of APOE variants on mortality in elderly patients independently of age-related diseases.…”

Section: Discussioncontrasting

confidence: 65%

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Matera

Sancarlo

Gravina

et al. 2010

AGE

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The most common apolipoprotein E (APOE) allelic variation is implicated in many age-related diseases and human longevity with controversial findings. We investigated the effect of APOE gene polymorphism on all-cause mortality in elderly patients taking into consideration the functional disability, cognitive impairment, malnutrition, and the occurrence of common age-related diseases. APOE genotypes were determined in 2,124 geriatric hospitalized patients (46.5% men and 53.5% women; mean age, 78.2 +/- 7.1 years; range, 65-100 years). At hospital admission, all patients underwent a comprehensive geriatric assessment to evaluate functional disability, cognitive status, nutritional status, and comorbidity. The main and secondary diagnoses at hospital discharge were also recorded. Mortality status was evaluated in all patients after a maximum follow-up of 5 years (range, from 1.26 to 5.23 years; median, 2.86 years). During the study period, 671 patients died (32.0%). At hospital admission, these patients showed a significant higher prevalence of cardiovascular diseases (56.3% vs 53.4%; p = 0.007), neoplasias (32.3% vs 13.7%; p < 0.001), and lower prevalence of neurodegenerative diseases (17.7% vs 20.7%; p < 0.001) than survived patients. Moreover, they also showed an higher prevalence of disability (52.0% vs 25.6%; p < 0.001), cognitive impairment (31.0% vs 18.8%; p < 0.001), and malnutrition (74.0% vs 46.1%; p < 0.001) than survived patients. In the overall study population, the APOE epsilon2 allele was significantly associated to neurodegenerative diseases (odds ratio = 0.59; 95% confidence interval (CI), 0.37-0.94). No significant association between the APOE polymorphism and disability, malnutrition, co-morbidity status, and with all-cause mortality was observed. In patients with cardiovascular diseases, however, a decreased risk of all-cause mortality was found in the epsilon2 allele carriers (hazard ratio = 0.56; 95% CI, 0.36-0.88). In this population, APOE allele variants might play a role on cardiovascular disease-related mortality.

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Section: Discussioncontrasting

confidence: 65%

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Matera

Sancarlo

Gravina

et al. 2010

AGE

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“…This is supported by other studies on family style mealtimes (Franzoni, Frisoni, Boffelli, Rozzini, & Trabucchi, 1996;Nijs et al, 2006). Thus, sharing meals can probably be considered simply as a good practice issue more than a therapeutic issue.…”

Section: Resultsmentioning

confidence: 63%

Sharing Meals With Institutionalized People With Dementia: A Natural Experiment

Charras

Frémontier

2010

Journal of Gerontological Social Work

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Nutritional deficiency can have dramatic effects on the physical and psychological status of older adults. Although food supplements can enhance nutritional status, several authors suggest that more ecological means could also have beneficial impacts. Therefore, a natural experiment was conducted to study the impact of changed mealtime experiences for people with Alzheimer-type dementia. Two special care units (in separate facilities) in France were included in this study: one implemented shared meal times between residents and caregivers and the other served as a comparison group. Weight was measured and staff observations were collected. Positive outcomes were observed for the experimental group. Implications for practice are discussed.

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“…Our study relates body mass index to brain atrophy in persons who are relatively early in the course of their cognitive decline. These results would not apply to persons in very advanced states in dementia, for whom lack of adequate food intake is often a major predictor of mortality (Franzoni et al, 1996). Rather, our work is best applied from the standpoint of understanding how control of body weight and other lifestyle factors may promote healthy brain aging and reduce the partly preventable risks for cognitive impairment and dementia.…”

Section: Discussionmentioning

confidence: 99%

Obesity is linked with lower brain volume in 700 AD and MCI patients

Ho¹,

Raji²,

Becker³

et al. 2010

Neurobiology of Aging

174

154

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Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer’s disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from two different cohorts: the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, N=399; CHS, N=77) and AD (ADNI, N=188; CHS, N=36). In both AD and MCI groups, higher BMI was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.

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Good Nutritional Oral Intake Is Associated with Equal Survival in Demented and Nondemented Very Old Patients

Abstract: Dementia developing in very old age is not necessarily associated with malnutrition and decreased life expectancy.

Cited by 63 publications

References 28 publications

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Apolipoprotein E-related all-cause mortality in hospitalized elderly patients

Sharing Meals With Institutionalized People With Dementia: A Natural Experiment

Obesity is linked with lower brain volume in 700 AD and MCI patients

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