Gonorrhoea treated by a combination of probenecid and sodium penicillin G.

Olsen, G A; G, Lomholt

doi:10.1136/sti.45.2.144

Cited by 44 publications

(23 citation statements)

References 8 publications

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“…A comparison of some findings from the United Kingdom (Table IV) shows a variable picture, but with a tendency for the proportion of relatively resistant strains to increase in recent years. There is evidence that improving the therapeutic results by raising the dosage of penicillin lowers the prevalence of partially resistant strains (Letchner and Nicol, 1961;Morton, 1963;Odegaard and Gjessing, 1967); this was particularly well shown by Olsen and Lomholt (1969) in Greenland, who demonstrated a fall in incidence of partially resistant strains from 54 to 19 per cent. after the introduction of treatment with 5 m.u.…”

Section: Discussionmentioning

confidence: 98%

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

Hilton¹

1971

Sexually Transmitted Infections

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Section: Discussionmentioning

confidence: 98%

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

Hilton¹

1971

Sexually Transmitted Infections

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“…Lomholt and Berg (1966) and Olsen and Lomholt (1968) treated gonorrhoea patients in Greenland with an oral dose of 1 g. probenecid, followed after 30 minutes by an intramuscular injection of 5 million units sodium penicillin G dissolved in 8 ml. of a 0 5 per cent.…”

mentioning

confidence: 99%

Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined.

Gundersen¹,

Odegaard²,

Gjessing³

1969

Sexually Transmitted Infections

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It has been shown by sensitivity testing in vitro that the effect of ampicillin on most gonococcal strains is somewhat weaker than that of penicillin G, but the effect on strains less sensitive is better with ampicillin than with penicillin G. Reyn and Bentzon (1968), in support of this, found that the 50 per cent. inhibitory concentrations for the naturally-occurring more sensitive strains were about twice as high with ampicillin as with sodium penicillin G, whereas an opposite tendency was observed in the less sensitive strains.As the great majority of relapses after treatment with penicillin occur in patients infected with gonococci with reduced sensitivity to penicillin, it is therefore possible that ampicillin could be an effective remedy in the treatment of gonorrhoea. This has proved to be the case. Willcox (1963) found a failure rate of 11 9 per cent. in male patients with uncomplicated gonorrhoea treated with a single oral dose of 0 5 g. ampicillin, which proved comparable to the results achieved with single injections of aqueous procaine penicillin. Willcox (1964) ampicillin combined with one simultaneous injection of 600,000 units procaine penicillin the relapse frequency was 3 per cent., whereas 500 patients *Received for publication February 18, 1969. treated with procaine penicillin only showed a relapse rate 11-6 per cent.Probenecid, which impedes the excretion of penicillin from the body and thus causes a higher serum concentration and a longer duration of penicillinaemia, was given, together with an intramuscular injection of sodium penicillin G, to gonorrhoea patients by Jensen, Kvorning, and Norredam (1963) Roholt (1965), can give an initial penicillinaemia of up to 200 units/ml., and after 8 hours, an average concentration of 5 units/ml. Of the 832 patients treated, there were only eight who relapsed; all had had sexual intercourse after the first treatment and all were cured after a repetition of the treatment. It is therefore highly probable that these cases were not relapses but re-infections and that the cure rate was 100 per cent.We have not been able to find any publication describing the use of an oral dose of ampicillin and probenecid combined in the treatment of gonorrhoea. The object of this paper is to show the results of such treatment. Material and Methods

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“…In every case subcultures were finally examined for their sensitivity in vitro to penicillin, streptomycin, and tetracycline by a plate-dilution technique (Olsen and Lomholt, 1969).…”

Section: Methodsmentioning

confidence: 99%

Gonorrhoea treated by a combination of probenecid and sodium penicillin G.

Cited by 44 publications

References 8 publications

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

PAM plus probenecid and procaine penicillin plus probenecid in gonorrhoea.

Treatment of gonorrhoea by one oral dose of ampicillin and probenecid combined.

Value of vaginal and rectal cultures in the diagnosis of gonorrhoea. With special reference to areas with limited medical facilities.

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