Gonococcal endocarditis: a case report and literature review

Nie, Shaoping; Wu, Yan; Huang, Lie; Pincus, David; Tang, Yi‐Wei; Lu, Xin-Jiang

doi:10.1007/s10096-013-1921-x

Cited by 18 publications

(31 citation statements)

References 36 publications

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“…before 1938), gonorrhea was responsible for up to 26% of all bacterial endocarditis 8 - 12 and was almost uniformly fatal. 8 , 13 Since then, the number of endocarditis infections substantially declined, although gonorrhea remained among the four most frequent sexually transmitted diseases worldwide. 14 The incidence of gonococcal endocarditis (GE) substantially decreased after the advent of penicillin.…”

Section: Discussionmentioning

confidence: 99%

“… 8 In parallel, a better outcome was observed, with an 88.5% survival rate (in a report of 26 patients treated exclusively with antibiotics). 13 For uncertain reasons many cases occurred during the last three decades of the 20th century, but numbers decreased again in the first decade of the 21st century. 13 However, surprisingly, GE currently seems to be showing a resurgence.…”

Section: Discussionmentioning

confidence: 99%

“… 13 For uncertain reasons many cases occurred during the last three decades of the 20th century, but numbers decreased again in the first decade of the 21st century. 13 However, surprisingly, GE currently seems to be showing a resurgence. 8 …”

Section: Discussionmentioning

confidence: 99%

“…Up to 70 cases of GE were published from 1939 to 2014, 38 of them within the period from 1980 to 2014. 13 , 15 Based on these reviews, GE is characterized by the involvement of a young population, afflicting, in 85% of the cases, patients between 15 and 35 years old, with a slight predominance among males. 8 , 12 GE usually develops in native and intact valves, presenting large vegetation that involves the aortic valve in 50-72% of the cases, accompanied by ring abscesses.…”

Section: Discussionmentioning

confidence: 99%

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Gonococcal endocarditis: an ever-present threat

Campos¹,

Kawabata²,

Bittencourt³

et al. 2016

ACR

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The incidence of severe complications of the Neisseria gonorrhoeae infection has presented variations over recent decades since the advent of penicillin. Gonococcal endocarditis (GE) still remains an ever-present threat afflicting the society’s poor and sexually active young population. This entity frequently requires surgical intervention and usually exhibits a poor outcome. The interval between the onset of symptoms and the diagnosis does not usually exceed 4 weeks. One of the characteristics of GE is a proclivity for aortic valve involvement with large vegetation and valve ring abscess formation. The authors report the case of a young man with a 2-week history of fever, malaise, weakness, and progressive heart failure symptoms, who had no previous history of genital complaints or cardiopathy. The physical examination was consistent with acute aortic insufficiency, which was most probably of an infectious origin. The echocardiogram showed thickened aortic cusps and valve insufficiency. After hospital admission, the patient’s clinical status worsened rapidly and he died on the second day. The autopsy findings disclosed aortic valve destruction with vegetation and a ring abscess besides signs of septic shock, such as diffuse alveolar damage, acute tubular necrosis, and zone 3 hepatocellular necrosis. The blood culture isolated N. gonorrhoeae resistant to penicillin and ciprofloxacin. The authors call attention to the pathogen of this particular infectious endocarditis, and the need for early diagnosis and evaluation by a cardiac surgery team.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Gonococcal endocarditis: an ever-present threat

Campos¹,

Kawabata²,

Bittencourt³

et al. 2016

ACR

View full text Add to dashboard Cite

show abstract

“…In the preantibiotic era, up to one-quarter of cases of infective endocarditis were caused by NG, but nowadays, it has become extremely rare: only 70 cases have been reported since 1939, with 5 cases since 2000. 4,5 This subacute endocarditis mainly affects healthy young people without previous valvular disease. It occurs 3 to 6 weeks after the primary infection and is often preceded by arthritis and/or tenosynovitis.…”

mentioning

confidence: 99%