Gonococcal Aneurysm of the Ascending Aorta

Markowicz, Samuel; Anstey, James; Hites, Maya; Montesinos, Isabel; Roisin, Sandrine; Keyzer, Caroline; Jacobs, Frédérique

doi:10.1097/olq.0000000000000079

Sexually Transmitted Diseases

2014

DOI: 10.1097/olq.0000000000000079

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Gonococcal Aneurysm of the Ascending Aorta

Samuel Markowicz¹,

James Anstey²,

Maya Hites³

et al.

Abstract: We present the case of a man with a bicuspid aortic valve who presented with persistent fever. Blood cultures yielded Neisseria gonorrhoeae, and the diagnosis of infected mycotic aneurysm was confirmed by detection of the bacterial genome in the aortic wall. The patient was cured with surgery and intravenous ceftriaxone.

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Cited by 2 publications

(1 citation statement)

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“…1 Among the other causative organisms of mycotic aortic aneurysm (MAA) reported from the Philippines are Salmonella, Mycobacterium tuberculosis, Burkholderia pseudomallei and Neisseria gonorrhoeae. [2][3][4][5][6] The difficulty in diagnosis and management is due to the rarity of the condition, the insidiousness of the presentation and the high-risk condition of the affected patients, all of which complicate medical and surgical treatment. This case study describes a virulent methicillin-resistant S aureus (MRSA) IE complicated by contained rupture of MAA and post-procedural endoleak type IIIa, treated with culture-guided antibiotics and a timely hybrid, two-staged procedure combined with the deployment of two overlapped thoracic endografts.…”

mentioning

confidence: 99%

Complicated Mycotic Thoracic Aortic Aneurysm Secondary to Staphylococcus aureus Endocarditis

Chua

Toledano

Prado

2023

J Asian Pac Soc Cardiol

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A mycotic aortic aneurysm is a rare and life-threatening condition, with the most common culprit being Staphylococcus aureus. The incidence varies widely from 0.6% to 13%. It usually affects immunocompromised patients, such as those undergoing haemodialysis who are subjected to repeated skin punctures. The insidiousness of the presentation of this high-risk condition makes diagnosis and management challenging. The authors document the case of a 75-year-old woman with multiple comorbidities on maintenance haemodialysis, who also recently underwent central line reinsertions, presenting with progressive leukocytosis and persistent anaemia. Diagnostic work-ups initially showed pneumonia and methicillin-resistant S aureus bacteraemia, later revealing infective endocarditis and a mycotic aortic aneurysm in the descending aorta with contained rupture. A hybrid two-step procedure with debranching and anastomoses of aortic branches was employed, followed by transthoracic endovascular aortic repair. However, the initial success was complicated by a type IIIa endoleak and was repaired using a tapered endograft stent deployed in an overlapping fashion to cover the leak. Long-term management involves a single antiplatelet and antibiotics taken according to the patient’s condition and close surveillance of imaging.

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mentioning

confidence: 99%

Complicated Mycotic Thoracic Aortic Aneurysm Secondary to Staphylococcus aureus Endocarditis

Chua

Toledano

Prado

2023

J Asian Pac Soc Cardiol

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Generating a heterosexual bipartite network embedded in social network

Azizi

Lewis

et al. 2021

Appl Netw Sci

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We describe an approach to generate a heterosexual network with a prescribed joint-degree distribution embedded in a prescribed large-scale social contact network. The structure of a sexual network plays an important role in how all sexually transmitted infections (STIs) spread. Generating an ensemble of networks that mimics the real-world is crucial to evaluating robust mitigation strategies for controlling STIs. Most of the current algorithms to generate sexual networks only use sexual activity data, such as the number of partners per month, to generate the sexual network. Real-world sexual networks also depend on biased mixing based on age, location, and social and work activities. We describe an approach to use a broad range of social activity data to generate possible heterosexual networks. We start with a large-scale simulation of thousands of people in a city as they go through their daily activities, including work, school, shopping, and activities at home. We extract a social network from these activities where the nodes are the people, and the edges indicate a social interaction, such as working in the same location. This social network captures the correlations between people of different ages, living in different locations, their economic status, and other demographic factors. We use the social contact network to define a bipartite heterosexual network that is embedded within an extended social network. The resulting sexual network captures the biased mixing inherent in the social network, and models based on this pairing of networks can be used to investigate novel intervention strategies based on the social contacts among infected people. We illustrate the approach in a model for the spread of chlamydia in the heterosexual network representing the young sexually active community in New Orleans.

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Gonococcal Aneurysm of the Ascending Aorta

Cited by 2 publications

References 9 publications

Complicated Mycotic Thoracic Aortic Aneurysm Secondary to Staphylococcus aureus Endocarditis

Complicated Mycotic Thoracic Aortic Aneurysm Secondary to Staphylococcus aureus Endocarditis

Generating a heterosexual bipartite network embedded in social network

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