Gonadotrophin Releasing Hormone: From Physiology to Pharmacology

The effect of long-term pulsatile GnRH administration on the 24-hour integrated concentration of GH in hypogonadotropic hypogonadic patients

“…It is well known that testosterone increases GH respon¬ siveness to arginine-and insulin-induced hypo¬ glycemia in prepubertal and pubertal subjects IHH and IDP are due to different degrees of im¬ paired neuroendocrine controi of GnRH biosyn¬ thesis and release from the hypothafamus (Clayton 1987). Both these pathological conditions can be compared with experimental conditions allowing the study of physiological activation of the pituitary-gonadal axis by exogenous GnRH and its ef¬ fect on GH secretion.…”

GnRH-Analoga in der Reproduktionsmedizin

“…Aufbauend auf diesen Forschungsergebnissen beschäftigen sich seit dieser Zeit zahlreiche Wissenschaftler in aller Welt mit synthetischer Herstellung von GnRH-Analoga [8]. Durch Veränderung der Aminosäurensequenz des natürlichen GnRH konnte man GnRH-Analoga synthetisch herstellen, die eine höhere Aktivität und eine längere Wirkungsdauer aufweisen.…”

Male Contraception: Current Status and Future Prospects

“…LHRH antagonists on the other hand competitively block receptor activation and are produced by substituting up to five amino acid residues in the decapeptide (for review see Karten & Rivier, 1986;Clayton, 1987). The latter is secreted in discrete pulses every 2 h, the intermittent pattern of pituitary stimulation being responsible for normal pulsatile gonadotrophin secretion.…”