Gonadal Steroids

Manolagas, Stavros C.; Almeida, Maria; Jilka, Robert L.

doi:10.1002/9781118453926.ch25

Cited by 4 publications

(3 citation statements)

References 74 publications

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“…Additionally, as conducted by Kemper et al [34], this study controlled regression analyses with sex and also obtained significant relationships between childhood MFI and adulthood BHI. There is a need to control the variable sex in analyses involving muscle fitness and aBMD, due to hormonal aspects, body size [38] and preference for specific physical activities that are inherent to sex and may not reach thresholds that stimulate osteogenesis. With regard to SLJ, muscle fitness indicator, showed no statistically significant relationship with aBMD for any of the regions of interest, although some studies have reported positive association [27,41], others have reported negative association [40] and some found no association [41].…”

Section: Discussionmentioning

confidence: 99%

Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood

et al. 2023

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Background This study was aimed to examine the relationship between muscular fitness indicators in childhood and areal bone mineral density (aBMD) in adulthood and to verify whether the relationship is mediated by performance on muscular fitness indicators in adulthood. Methods A sample of 138 healthy adults (69 males; 22.3 years) were followed after a previous assessment at the age of 7–10 years. Stature, body mass and muscular fitness indicators (handgrip strength, standing long jump and sit-ups tests) were assessed in childhood and adulthood. Additionally, total body, upper limbs, lower limbs, right femoral neck and lumbar spine aBMD was assessed in adulthood using dual X-ray absorptiometry. Analysis included descriptive statistics; t-test or Mann-Whitney U-test for comparison between males and females, multiple linear regression for the prediction aBMD from muscular fitness indicators in childhood, mediation analysis of the respective muscular fitness indicators in adulthood and the relationship between muscular fitness indicators in childhood and aBMD. Results Males were stronger compared to females regarding muscular fitness indicators in childhood and adulthood, and presented higher mean values for aBMD in adulthood, except for lumbar spine (p < 0.05). Regression analysis revealed that some muscular fitness indicators in childhood showed significant positive relationship with bone health indicators in adulthood, such as: handgrip strength and total body aBMD (β = 0.005; R2 = 0.35; p = 0.040) and upper limbs aBMD (β = 0.005; R2 = 0.55; p = 0.019); and sit-ups test was a significant predictors of lumbar spine BMD (β = 0.003; R2 = 0.06; p = 0.039). Mediation analysis pointed out the following: adulthood handgrip strength mediated relationships between childhood handgrip strength and total aBMD (indirect effect (IE) = 0.0025; 95%CI = 0.0005–0.0048), and upper limbs aBMD (IE = 0.0040; 95%CI = 0.0017–0.0069). Conclusions Muscular fitness indicators in childhood showed significant relationship with bone health indicators in adulthood and the sit-ups test in childhood had direct effect on lumbar spine aBMD in adulthood. Adulthood handgrip strength mediated the relationship between childhood handgrip strength and total body and upper limb aBMD, pointing out that muscular fitness in childhood may be a aBMD determinant in adulthood, especially when higher muscle fitness performance is maintained in adulthood.

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Section: Discussionmentioning

confidence: 99%

Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood

et al. 2023

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“…Estrogen exerts many of its effects via two nuclear estrogen receptors (ERs), ERα and ERβ. Although both receptors have been detected in all skeletal cell types, for example chondrocytes, bone marrow stromal cells, osteoblasts, osteocytes and osteoclasts and their progenitor cells, the vast majority of the estrogen bone-sparing effects are mediated by ERα in both the cortical and cancellous bone compartments (31,32). By contrast, ERβ may not serve a major role in bone, with the possible exception that it may exert an inhibitory effect on periosteal apposition (30,31).…”

Section: Weeks 12 Weeks ---------------------------------------------mentioning

confidence: 99%

“…Although both receptors have been detected in all skeletal cell types, for example chondrocytes, bone marrow stromal cells, osteoblasts, osteocytes and osteoclasts and their progenitor cells, the vast majority of the estrogen bone-sparing effects are mediated by ERα in both the cortical and cancellous bone compartments (31,32). By contrast, ERβ may not serve a major role in bone, with the possible exception that it may exert an inhibitory effect on periosteal apposition (30,31). In the present study, DXA measurements demonstrated that the BA at the mid diaphysis, a site that is high in cortical bone, was significantly greater in the Ovx group than in the Sham group, whereas there was no difference in the mid diaphyseal BA between the Sham and Ovx+YCJ groups.…”

Section: Weeks 12 Weeks ---------------------------------------------mentioning

confidence: 99%

Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats

et al. 2017

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Abstract. Young coconut (Cocos nucifera Linn.) juice (YCJ) has traditionally been consumed to alleviate symptoms associated with the menopause. Recently, the authors demonstrated that short-term (6-week) YCJ supplementation to ovariectomized rats resulted in increased bone mass and bone formation parameter, suggesting that YCJ consumption has a positive effect on bone metabolism and may represent an intervention to help slow the bone loss during menopause transition. The present study sought to determine how long-term (12-week) YCJ supplementation affects bone metabolism in ovariectomized rats, to investigate whether such supplementation may be helpful to in osteoporosis treatment. Ten-week-old female Wistar rats were subjected to either a sham operation (Sham) or bilateral ovariectomy (Ovx). The Ovx+YCJ group received 5X-concentrated YCJ at a dose of 15 ml/kg/day for 12 weeks. Rats in the Ovx group had significantly lower femur bone mineral density than those in the Sham group. YCJ supplementation did not significantly affect this difference. However, YCJ prevented the increase in bone area of the mid third of the femur, a site high in cortical bone, and body weight gain observed following Ovx. Our findings indicate that long-term YCJ intake does not alter bone loss, but rather alleviates body weight gain following menopause.

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The Effects of Androgens on Bone Metabolism: Clinical Aspects

Sfeir

Drake

2020

Osteoporosis

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Gonadal Steroids

Cited by 4 publications

References 74 publications

Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood

Interrelationship between muscle fitness in childhood and bone mineral density in adulthood: mediation analysis of muscle fitness in adulthood

Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats

The Effects of Androgens on Bone Metabolism: Clinical Aspects

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