Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats

Abstract

Abstract. Young coconut (Cocos nucifera Linn.) juice (YCJ) has traditionally been consumed to alleviate symptoms associated with the menopause. Recently, the authors demonstrated that short-term (6-week) YCJ supplementation to ovariectomized rats resulted in increased bone mass and bone formation parameter, suggesting that YCJ consumption has a positive effect on bone metabolism and may represent an intervention to help slow the bone loss during menopause transition. The present study sought to determine how long-term (12-week) YCJ supplementation affects bone metabolism in ovariectomized rats, to investigate whether such supplementation may be helpful to in osteoporosis treatment. Ten-week-old female Wistar rats were subjected to either a sham operation (Sham) or bilateral ovariectomy (Ovx). The Ovx+YCJ group received 5X-concentrated YCJ at a dose of 15 ml/kg/day for 12 weeks. Rats in the Ovx group had significantly lower femur bone mineral density than those in the Sham group. YCJ supplementation did not significantly affect this difference. However, YCJ prevented the increase in bone area of the mid third of the femur, a site high in cortical bone, and body weight gain observed following Ovx. Our findings indicate that long-term YCJ intake does not alter bone loss, but rather alleviates body weight gain following menopause.

Long-term supplementation with young coconut juice help prevent bone loss of orchidectomized rats by increasing connectivity density, percentage bone volume and osteoblast-/osteocyte-(ERα-/ ERβ-) immunoreactive cells of the L5 vertebra and femur

“…Astragalin (AG), also known as teoporosis in andropausal or aging men. Considering, however, the results of our previous studies (Suwanpal et al, 2011;Yusuh et al, 2010), YCJ may be beneficial in lessening bone loss in men at early andropause at a young age, which we hypothesize may delay the need and lessen the time duration of anti-apoptotic treatment as reported by Morii et al (2015) and Matsushita et al (2017) who worked on osteoporotic female rats.…”

Untitled

“…Therefore, estrogen/phytoestrogen-YCJ may influence calcium-binding protein, CB, and VDR cell production, resulting in bone calcium deposition by increasing ERα-and ERβ-reactive cell numbers, %bone volume, and other factors Micro-CT parameters in the femur and L5 vertebra as occurred in this study.In summary, long-term YCJ consumption slightly improved indices of bone mass or bone histomorphometry in ORX rats, contending suggestion of the full benefits of YCJ for the prevention of os-teoporosis in andropausal or aging men. Considering, however, the results of our previous studies(Suwanpal et al, 2011; Yusuh et al, 2010), YCJ may be beneficial in lessening bone loss in men at early andropause at a young age, which we hypothesize may delay the need and lessen the time duration of anti-apoptotic treatment as reported byMorii et al (2015) andMatsushita et al (2017) who worked on osteoporotic female rats.CONCLUSIONYCJ had a noticeable effect and delayed the bone loss at trabecular structures associated with osteoporosis. Its effects, however, did not achieve the level of the estrogen-protective effect on the microfracture incidence, the basis of osteoporotic fractures.…”

Irisin Signaling Pathway is up Regulated by Resistance Training in Ovariectomized Rats

“…Ovariectomized animals present body weight gain, and these effects indicate that estrogens play a pivotal role in preventing excess body weight gain in females [31][32][33][34][35].…”