Gonadal sex differentiation in teleost fish

Nakamura, Masaru; Kobayashi, Tohru; Chang, Xiaotian; Nagahama, Yoshitaka

doi:10.1002/(sici)1097-010x(19980801)281:5<362::aid-jez3>3.0.co;2-m

Cited by 396 publications

(306 citation statements)

References 46 publications

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“…In XY gonads, the medullary cell mass derived from the germinal epithelium, neighbored the germ-cell-surrounding cells and developed into a cord-like structure as the intratesticular efferent duct. Although no medullary cell mass developed in the XX gonads, an ovarian cavity was formed by the extension of both tips of the gonads (Nakamura et al, 1998).…”

Section: Gonadal Sex Differentiationmentioning

confidence: 99%

“…In nonmammalian vertebrates, the sex reversal of gonads has been demonstrated in both sexes (Reinboth, 1983;Scheib, 1983). In teleost fish, in particular, a complete sex reversal of gonads in both sexes can be induced by the administration of sex steroid hormones, and in some cases, by modulating environmental factors (Yamamoto, 1953(Yamamoto, , 1958(Yamamoto, , 1969Nakamura et al, 1998;Baroiller et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…Although a little information on DMRT1 and Sox9 during gonadal sex differentiation has been reported in teleost fish, to date, no information on DMRT1 and Sox9 expression during gonadal sex differentiation has been reported from the viewpoint of a comparison with the signs of morphological sex difference. Nile tilapia, Oreochromis niloticus, is a diploid fish (XX-XY-type) well characterized as a model for gonadal sex differentiation (Nakamura et al, 1998(Nakamura et al, , 1999. In this species, sex reversal is easily inducible using hormones, and sex-reversed males (XX) and supermales (YY) have been produced (Nakamura et al, 1998;Carrasco et al, 1999;Kobayashi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Nile tilapia, Oreochromis niloticus, is a diploid fish (XX-XY-type) well characterized as a model for gonadal sex differentiation (Nakamura et al, 1998(Nakamura et al, , 1999. In this species, sex reversal is easily inducible using hormones, and sex-reversed males (XX) and supermales (YY) have been produced (Nakamura et al, 1998;Carrasco et al, 1999;Kobayashi et al, 2003). Consequently, all-male or all-female populations can be easily produced using these males .…”

Section: Introductionmentioning

confidence: 99%

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Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone‐induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)

Kobayashi

Kajiura-Kobayashi

Guan

et al. 2007

Developmental Dynamics

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162

107

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We examined the expression profiles of tDMRT1 and Sox9a during gonadal sex differentiation and hormoneinduced sex reversal. tDMRT1 was detected in the gonial germ-cell-surrounding cells in XY fry specifically before the appearance of any signs of morphological sex differentiation, that is, sex differences in germ cell number and histogenesis, such as differentiation into intratesticular efferent duct or ovarian cavity. The signals became localized in the Sertoli and epithelial cells comprising the efferent duct during gonadal differentiation. After the induction of XY sex reversal with estrogen, tDMRT1 decreased and then disappeared completely. In contrast, tDMRT1 was expressed in the germ-cell-surrounding cells in XX sex reversal with androgen. On the other hand, Sox9a did not show sexual dimorphism before the appearance of sex differences in histogenesis and was not expressed in the efferent duct in the testis. These results suggest that tDMRT1 is a superior testicular differentiation marker in tilapia. Developmental Dynamics 237: 297-306, 2008.

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Section: Gonadal Sex Differentiationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone‐induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)

Kobayashi

Kajiura-Kobayashi

Guan

et al. 2007

Developmental Dynamics

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162

107

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“…During this process, numerous approaches including classic morphological examination, immuno-histochemistry, analysis of steroidogenic enzyme gene expression, and experimental inductions of sex inversion have revealed that steroid hormones are likely to play a crucial role in gonadal sex differentiation in fish (Nakamura et al, 1998;Guiguen, 2000;Devlin and Nagahama, 2002). For instance, it is now well accepted that endogenous estrogens are among the main effectors able to trigger fish ovarian differentiation (Nakamura et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Characterization of early molecular sex differentiation in rainbow trout, Oncorhynchus mykiss

Vizziano

Randuineau²,

Báron³

et al. 2007

Developmental Dynamics

180

171

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Early differentiation in rainbow trout gonads was investigated by expression profiling and in situ hybridization (ISH). Expression of cyp19a1 and fst in females and sox9a1 in males were sexually dimorphic between 32 to 35 days post-fertilization (dpf). After 35 dpf, the differentiation proceeded with sexually dimorphic profiles for sox9a2, dmrt1, cyp11b2.1, amh in males and foxl2a, foxl2b, hsd3b1, inha in females. cyp17a1, cyp11a1, star, nr5a1b increased only after 40 dpf in both sexes with a slightly higher expression in females. cyp19a1 expression was localized in a cluster of somatic cells in the ventral side of female gonads, and sox9a2 and amh in somatic cells surrounding the germ cells, at 28 dpf and thereafter, both in male and female gonads. cyp11b2.1, cyp17a1, and cyp11a1 expressions were only detected in scattered somatic cells in males after 46 dpf. This confirms the early implication of cyp19a1 in trout ovarian differentiation and suggests that early testicular differentiation does not need androgen production. Developmental Dynamics

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Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus)

Guiguen¹,

Baroiller

Ricordel³

et al. 1999

Mol. Reprod. Dev.

282

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Gonadal sex differentiation in teleost fish

Cited by 396 publications

References 46 publications

Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone‐induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)

Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone‐induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus)

Characterization of early molecular sex differentiation in rainbow trout, Oncorhynchus mykiss

Involvement of estrogens in the process of sex differentiation in two fish species: The rainbow trout (Oncorhynchus mykiss) and a tilapia (Oreochromis niloticus)

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