Gonadal Hormone Influences on Sex Differences in Binge Eating Across Development

Mikhail, Megan E.; Anaya, Carolina; Culbert, Kristen M.; Sisk, Cheryl L.; Johnson, Alexander W.; Klump, Kelly L.

doi:10.1007/s11920-021-01287-z

Cited by 13 publications

(16 citation statements)

References 99 publications

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“…Similarly to N/OFQ-NOP system, considerable evidence suggested sex differences in other orexigenic signaling mechanisms implicated in binge eating, such those depending on the relaxin-family peptide-3 [244,245] and orexin-1 receptors [246][247][248]. This is not surprising considering that sexual dimorphism has been described in binge eating behavior both in humans [249][250][251] and animals [252][253][254][255][256]. In light of the complex role of N/OFQ in feeding regulation, and based on the current knowledge, it is difficult to provide an unambiguous interpretation of the effect of NOP on binge eating.…”

Section: Role Of the N/ofq-nop System In The Regulation Of Feeding And Food-related Disordersmentioning

confidence: 99%

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Ubaldi

Cannella

Borruto

et al. 2021

IJMS

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Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence homology with the precursors of other opioid neuropeptides but it does not activate either MOP, KOP or DOP receptors. Furthermore, opioid neuropeptides do not activate the NOP receptor. Generally, activation of N/OFQ system exerts anti-opioids effects, for instance toward opioid-induced reward and analgesia. The NOP receptor is widely expressed throughout the brain, whereas N/OFQ localization is confined to brain nuclei that are involved in stress response such as amygdala, BNST and hypothalamus. Decades of studies have delineated the biological role of this system demonstrating its involvement in significant physiological processes such as pain, learning and memory, anxiety, depression, feeding, drug and alcohol dependence. This review discusses the role of this peptidergic system in the modulation of stress and stress-associated psychiatric disorders in particular drug addiction, mood, anxiety and food-related associated-disorders. Emerging preclinical evidence suggests that both NOP agonists and antagonists may represent a effective therapeutic approaches for substances use disorder. Moreover, the current literature suggests that NOP antagonists can be useful to treat depression and feeding-related diseases, such as obesity and binge eating behavior, whereas the activation of NOP receptor by agonists could be a promising tool for anxiety.

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Section: Role Of the N/ofq-nop System In The Regulation Of Feeding And Food-related Disordersmentioning

confidence: 99%

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Ubaldi

Cannella

Borruto

et al. 2021

IJMS

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“…Studies of obesity have produced more mixed results, with substantial variation in findings by developmental stage, sample characteristics (e.g., ADHD symptoms, pubertal stage, IQ), and task type (e.g., real vs. hypothetical) 17,25 . Pubertal status may be a particularly important confounder to consider given the impact of puberty on body weight, 26 eating behavior, 27 and brain development 28 …”

Section: Introductionmentioning

confidence: 99%

“…23,24 Studies of obesity have produced more mixed results, with substantial variation in findings by developmental stage, sample characteristics (e.g., ADHD symptoms, pubertal stage, IQ), and task type (e.g., real vs. hypothetical). 17,25 Pubertal status may be a particularly important confounder to consider given the impact of puberty on body weight, 26 eating behavior, 27 and brain development. 28 As far as we are aware, no published studies have examined whether experiential DD using a salient, concrete non-food reward varies by body weight in either TD children or children with ADHD.…”

Section: Introductionmentioning

confidence: 99%

“…Critically, TD children had ADHD symptom scores that were substantially below clinical cutoffs on all parent/teacher rating scales, allowing us to identify dimensions of CC and DD specific to obesity in the absence of other co-morbidities, and supplementary analyses controlled for stimulant use, which could obscure relationships with weight 29 due to appetite suppression and potentially via improved self-control. The sample was predominantly pre-pubertal, important both to avoid confounding from hormonal effects on body weight, eating behavior and brain development, [26][27][28] and because characterizing prepubertal neurobehavioral risk factors for later obesity or ADHD [30][31][32] could inform early life prevention and intervention approaches. We hypothesized that ADHD and higher BMIz would both be associated with greater DD (reflecting a shared phenotype), with greatest DD in children with both higher BMIz and ADHD, and greater effects for the game time DD than the money DD task.…”

Section: Introductionmentioning

confidence: 99%

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Neurobehavioral phenotypes of delay discounting and cognitive control in child attention‐deficit/hyperactivity disorder and obesity: Shared or distinct?

Thapaliya¹,

Carnell²,

Mostofsky

et al. 2023

Pediatric Obesity

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Background: Attention-deficit/hyperactivity disorder (ADHD) and obesity have been independently associated with deficient cognitive control (CC) and heightened preference for immediate reward. Objectives: We aimed to identify specific shared and distinct neurobehavioral phenotypes of child obesity and ADHD by simultaneously measuring CC and preference for immediate reward in children with and without ADHD who varied in body weight. Methods: This case-control study included 323 8-12 year olds (ADHD n = 215, typically developing (TD) screened for ADHD symptoms [TD] controls n = 108) varying in body weight. Children completed a go/no-go task (assessing CC), as well as a classical money delay discounting (DD) task and novel experiential game time DD task (assessing preference for immediate over delayed rewards).Results: For game time DD, there was a body mass index z-score (BMIz)*ADHD interaction, such that TD children with overweight/obesity showed game time DD levels that were greater than those of TD children without overweight/obesity and similar to those of children with ADHD. Only children with ADHD showed poorer CC compared to TD children, with no effects of body weight.Conclusions: Heightened game time DD with delays and rewards experienced in real-time may represent a neurobehavioral phenotype that is shared between ADHD and overweight/obesity in childhood, whereas deficient CC may be specific to children with ADHD.

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“…Initial research suggests the impact of disadvantage on disordered eating may be amplified for individuals with underlying genetic vulnerabilities through diathesis-stress G × E, particularly during puberty, a developmentally sensitive risk period for the emergence of EDs (e.g., Mikhail et al, 2021; Nagl et al, 2016). In a recent study, our group found that phenotypic ED symptoms were greater for girls experiencing familial or neighborhood disadvantage.…”

mentioning

confidence: 99%

Disadvantage and disordered eating in boys: Examining phenotypic and genotype × environment associations across development.

Mikhail¹,

Carroll²,

Clark³

et al. 2023

Journal of Psychopathology and Clinical Science

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Socioeconomic disadvantage may be a significant risk factor for disordered eating, particularly for individuals with underlying genetic risk. However, little to nothing is known about the impact of disadvantage on disordered eating in boys during the critical developmental risk period. Crucially, risk models developed for girls may not necessarily apply to boys, as boys show different developmental patterns of disordered eating risk (i.e., earlier activation of genetic influences during adrenarche, an early stage of puberty). This is the first study to examine phenotypic and Genotype 3 Environment (G 3 E) effects of disadvantage in boys. Analyses examined 3,484 male twins ages 8-17 (M age = 12.27, SD = 2.96) from the Michigan State University Twin Registry. Disordered eating (e.g., body dissatisfaction, binge eating) was measured using the parent-report Michigan Twins Project Eating Disorder Survey. Neighborhood disadvantage was measured using a census-tract level Area Deprivation Index, and family socioeconomic status was determined from parental income and education. Adrenarche status was determined using multiple indicators, including age and Pubertal Development Scale scores. G 3 E models suggested that genetic influences on disordered eating were activated earlier for boys experiencing familial or neighborhood disadvantage, with substantial genetic influences in early adrenarche, when genetic influences were low in more advantaged boys. Phenotypically, both neighborhood and familial disadvantage were associated with greater disordered eating for boys in late adrenarche, which could indicate a lasting impact of earlier activation of genetic influences on later risk. Results highlight disadvantage as a novel risk factor for disordered eating in boys, particularly those with genetic vulnerabilities.

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Gonadal Hormone Influences on Sex Differences in Binge Eating Across Development

Cited by 13 publications

References 99 publications

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

Neurobehavioral phenotypes of delay discounting and cognitive control in child attention‐deficit/hyperactivity disorder and obesity: Shared or distinct?

Disadvantage and disordered eating in boys: Examining phenotypic and genotype × environment associations across development.

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