Gonadal function, sexual behavior, feedlot performance, and carcass traits of ram lambs actively immunized against GnRH.

Kıyma, Z.; Adams, Thomas E.; Hess, B. W.; Riley, M. L.; Murdoch, William J.; Moss, G. E.

doi:10.2527/2000.7892237x

Cited by 62 publications

(52 citation statements)

References 21 publications

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“…The significant difference between body weights of animals administered with GnRH-KLH with ISCOMs compared to the negative control group in both trials by Weeks 8-9 could be the result of diminished anabolic effects due to steroid deprivation which might have occurred because of reproductive organ atrophy. Similar results have been reported for GnRH immunised or castrated animals (various species) in many previous studies [10,36,37]. Similarly, mean body weight of the group administered with Gonacon TM in Trial 1 was significantly less compared to negative control group (P < 0.05) at Week 9, although the difference was not maintained through to Week 12 probably due to the variability in reproductive organ atrophy among animals administered with Gonacon TM .…”

Section: Discussionsupporting

confidence: 88%

Parenteral administration of GnRH constructs and adjuvants: Immune responses and effects on reproductive tissues of male mice

Sharma

McDonald

Miller³

et al. 2014

Vaccine

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a b s t r a c tTwo gonadotrophin releasing hormone (GnRH) constructs prepared by either chemical conjugation to keyhole limpet hemocyanin (GnRH-KLH) or as an expressed recombinant fusion protein (Multimer) were evaluated with or without adjuvants (immunostimulating complexes, ISCOMs, or cytosine-phosphateguanosine oligodeoxynucleotides, CpG ODNs). After subcutaneous administration to Balb/c male mice at Weeks 0, 2 and 4, these preparations were assessed for induction of immune responses and effects on reproductive organs. GnRH-KLH plus ISCOMs formulation induced strong IgG immune responses from Week 4 through Week 12 resulting in consistent reproductive organ atrophy by Week 12 after subcutaneous administration. GnRH-KLH plus CpG ODNs generated immune responses but no atrophy of reproductive tissues by Week 12. Multimer plus ISCOMs induced poor immune responses and no effects on reproductive tissues by Week 12. In the absence of additional adjuvant, none of the GnRH constructs induced reproductive organ atrophy. GnRH-KLH induced stronger immune responses when formulated with ISCOMs or CpG ODN compared to Multimer. GnRH-KLH with ISCOMs could be an effective colloidal alternative for emulsion GnRH vaccine formulations.

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Section: Discussionsupporting

confidence: 88%

Parenteral administration of GnRH constructs and adjuvants: Immune responses and effects on reproductive tissues of male mice

Sharma

McDonald

Miller³

et al. 2014

Vaccine

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“…Sales (2014) found that wether lambs had greater dressing percentage and BFT, but LMA was lower when compared with rams. Kiyma et al (2000) found that fat deposition in wethers require a prolonged testosteronedeficient condition, whereas suppression of sexual behavior and reduction of feed efficiency occurs more rapidly after castration.…”

Section: Resultsmentioning

confidence: 99%

<b>Time on feedlot and sexual effects on animal performance and characteristics of lamb’s meat

Mazon

Carvalho

Pesce

et al. 2017

Acta Sci. Anim. Sci.

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ABSTRACT. For this research 48 male lambs were divided in randomized blocks in a factorial design, having as factors sexual condition (castrated or uncastrated) and time on feed (36 or 78 days). High grain diet was monitored daily to measure the performance of the animal nutrition. The characteristics of the carcass and meat were taken for the fatty acids profile and sensorial analysis. The effect of the factors as sexual condition and time on feed, and the interaction between them, were evaluated by analysis of variance using the GLM procedure of SAS software and the treatment averages were compared by Student's T test. The uncastrated animals presented greater weight gain and dry matter intake, better feed efficiency, and larger loin area. More time on feed resulted in higher weight at slaughter. Parameters such as pH, color, meat tenderness and sensorial attributes were not affected by treatments. For the fatty acid profile there was effects and interactions between sexual condition and time on feed. It is concluded that castration should not be used when the animal is young and slaughtered and feed intensively, but neutering can be interesting to improve the fatty acid profile of the meat.Keywords: castrated, Dorper, fatty acids, meat, Santa Inês, sheep.Período de confinamento e efeito do sexo sobre o desempenho e características de qualidade da carne de cordeiros RESUMO. No experimento realizado, foram utilizados 48 cordeiros machos divididos em blocos casualizados, em esquema fatorial, sendo tais fatores: a condição sexual (castrado ou não castrado) e tempo de confinamento (36 ou 78 dias). Uma dieta rica em grãos foi ofertada e controlada diariamente para medir o desempenho da nutrição animal, as características da carcaça e da carne foram avaliadas, e foi feita análise sensorial. A condição sexual e o tempo em confinamento, bem como a interação entre eles, foram avaliados por análise de variância, utilizando o procedimento GLM do software SAS e as médias dos tratamentos foram comparadas pelo teste t de estudante (p < 0,05). Os animais não castrados apresentaram maior ganho de peso e consumo de matéria seca. Eles também tiveram uma melhor eficiência alimentar e área de lombo. Mais tempo no confinamento resultou em maior peso ao abate. Parâmetros como pH, cor, maciez da carne e atributos sensoriais não foram afetados pelos tratamentos. Para o perfil de ácidos graxos, houve efeitos e as interações entre condição sexual e tempo de confinamento. Concluiu-se que a castração não deve ser usada quando o animal é novo e criado em sistema intensivo, mas a castração pode ser interessante para melhorar o perfil de ácidos graxos da carne.

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“…However, the feeding period required for the immunocastrates to reach a slaughter weight of 58 kg was intermediate to the other two sexes, while yielding more desirable yield grades with less fat and marbling than physical castrates. These results indicated a possible difference in nutrient partitioning for growth and fat deposition between immunocastrates and physical castrates (Kiyma et al, 2000). Immunocastration increased dressing percentages in comparison to intact rams, which could be due to the smaller testes weight in comparison to intact males as well as a decrease in kidney and pelvic fat in comparison to physical castrates (Kiyma et al, 2000).…”

Section: Small Ruminantsmentioning

confidence: 89%

“…This vaccination technique was used to vaccinate Western Whiteface rams at 32.6 ± 1 kg, causing decreased testosterone and testicle weights at slaughter with a resultant decrease in mounting frequencies and ejaculations in the growing period (Kiyma et al, 2000). Two adjuvants were also compared for vaccination, indicating that FCA achieved the greatest GnRH antibody titres at slaughter and greatest decrease in sexual behaviours.…”

Section: Small Ruminantsmentioning

confidence: 99%

Castration of male livestock and the potential of immunocastration to improve animal we

Needham¹,

Lambrechts²,

Hoffman³

2017

SA J. An. Sci.

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Growing consumer awareness about animal welfare has led to the assessment of the impact of common farming practices, such as physical castration, on animal well-being under production conditions. Physical castration is used in livestock industries to prevent indiscriminate breeding, control aggression, and improve meat and carcass quality. In terms of animal welfare, physical castration causes pain, decreased growth performance, infection, and mortality. An alternative approach to castration is thus warranted that will ensure optimal growth without compromising the castrated animal's wellbeing. Immunocastration has proved to be an effective method of suppressing the development and functioning of the reproductive system in various domesticated and wildlife species. The effect of immunocastration on production performance is welldocumented for both swine and cattle. Although ram lambs used for meat production are often physically castrated, information regarding the potential application of immunocastration in sheep is limited. However, immunocastration may potentially improve the welfare, performance, and meat quality of ram lambs used in commercial meat production systems. The purpose of this review is to compare the application and the effects of immunocastration on male livestock to highlight and motivate the need for further research into its use on ram lambs.

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Gonadal function, sexual behavior, feedlot performance, and carcass traits of ram lambs actively immunized against GnRH.

Cited by 62 publications

References 21 publications

Parenteral administration of GnRH constructs and adjuvants: Immune responses and effects on reproductive tissues of male mice

Parenteral administration of GnRH constructs and adjuvants: Immune responses and effects on reproductive tissues of male mice

<b>Time on feedlot and sexual effects on animal performance and characteristics of lamb’s meat

Castration of male livestock and the potential of immunocastration to improve animal we

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