Gonadal Effects of Vasectomy and Vasoligation

Sackler, Arthur M.; Weltman, Arthur; Pandhi, V.; Schwartz, R.

doi:10.1126/science.179.4070.293

Cited by 69 publications

(22 citation statements)

References 20 publications

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“…We have recently sought an alternative to the traditional method for vasectomy and examined the possibility of connecting the ductus deferens with the bladder. In this way, we hoped to prevent the formation of cysts in the epididymis and the ductus deferens (Smith, 1962;Sackler, Weltman, Pandhi & Schwartz, 1973) and the formation of antibodies against spermatozoa, both of which often occur in the rat after vasectomy or vasoligation (Riimke & Titus, 1970). After it was found that the operation could be carried out easily and that many Correspondence: Dr J.…”

Section: Introductionmentioning

confidence: 98%

The Effect of Hemicastration on Daily Sperm Output in the Rat as Measured by a New Method

Vreeburg¹,

Anđel²,

Kort³

et al. 1974

Reproduction

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Section: Introductionmentioning

confidence: 98%

The Effect of Hemicastration on Daily Sperm Output in the Rat as Measured by a New Method

Vreeburg¹,

Anđel²,

Kort³

et al. 1974

Reproduction

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“…We have previously observed that in immature rats vasec tomy interferes with the local testicular action of opioid peptides (naloxone, enkephalin treatment) [15]. Accord ing to the literature data in immature rats, vasectomy reduces testicular weight, and urinary 17-ketosteroid lev els [26]. Vasectomy in adults has no effect on the tubular spermatogenic cycle [27], ultrastructure of the testis [28] or plasma testosterone level [29], Hemivasectomy has been reported to suppress the testicular response to hemicastration as assessed by measuring testosterone concen tration in the veins of the remaining testis [30].…”

Section: Discussionmentioning

confidence: 99%

Testicular Injection of 5,6-Dihydroxytryptamine or Vasectomy Interferes with the Local Stimulatory Effect of Oxytocin on Testicular Steroidogenesis in Immature Rats

Gerendai

Csernus²

1996

Neuroendocrinology

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Previous studies indicated that in immature rats testicular administration of oxytocin stimulates testicular steroidogenesis. In the present study, testicular treatment with oxytocin (50 ng) was combined with pharmacological or surgical denervation of the testis in hemigonadectomized immature rats. For denervation 5,6-dihydroxytryptamine (160 µg/testis), a substance that destroys serotoninergic neuronal elements, was injected intratesticularly or vasectomy was performed, which also includes transection of the inferior testicular nerve. In 9-day-old animals both vasectomy and pretreatment of the testis with 5,6-dihydroxytryptamine prevented the oxytocin-induced rise in serum testosterone concentration. In addition, intratesticular injection of oxytocin combined with vasectomy resulted in a significant increase in in vitro basal testosterone secretion of the testis. A similar effect was not observed in the 5,6-dihydroxytryptamine-pretreated group receiving oxytocin. The results indicate that testicular innervation is involved in the control of local peptide effects, and data further suggest a differential role of these neural elements in intratesticular regulatory processes.

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“…The more proximal region reabsorbs about 46% of the fluid, and the remainder of the epididymis 23%. In addition, spermatic cysts at the cut end of the vas deferens or the epididymis are observed both in vasectomized man (Schmidt 1966) and in animals (Smith 1961(Smith -1962Flickinger 1972;Sackler et al 1973;Kwart and Coffey 1973;Neaves 1974;Howard,", et al 1975). The signi ficant weight changes of the head and tail of the epididymis seem to be simply explained by whether an inflow of spermatic fluid is blocked and whether a analysis of variance by t-test spermatic cyst is formed.…”

Section: Weight Of Seminal Vesicle and Ventral Prostatementioning

confidence: 99%

The Effects of Ligation of Vas Deferens, Corpus Epididymidis and Vasa Efferentia on the Testicular Function in Rats

Kuwahara

1976

Tohoku J. Exp. Med.

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Med., 1976, 120 (3), 251-257-The effects of ligation of the vas deferens, the corpus epididymidis and the vasa efferentia on the testicular function were studied in sexually mature rats. The significant decrease in the testicular weight was observed after ligation of the corpus epididymidis and the vasa efferentia. However, neither the weight of the ventral prostate and of the seminal vesicle, nor the plasma testosterone level showed significant changes. The results suggest that the ligation at the three locations would not affect the endocrine function of the testis. The changes in the testis would mainly affect the spermatogenesis. The effects of sperm stasis on the testicular function were also discussed. vas deferens; corpus epididymidis; vasa efferentia; testicular function Vasectomy has been generally accepted as a safe procedure in male contracep tions and used widely in the world as a means of population control. In recent years several reports have directed an attention to the relationship between an accumulation of the sperm in the ductal system and testicular function (Horan 1973(Horan , 1975Johnson and Howards 1975;Kuwahara and Frick 1975). Horan (1975) has shown in his animal experiments that epididymal stasis of the sperm caused testi cular atrophy, and when the stasis was dominant, testicular effects were invariably seen. He has further noticed interstitial cell hyperplasia after vasectomy which was reported also in man (Gupta et al. 1975). Kuwahara and Frick (1975) have shown a discrepancy of testicular histology between rats which formed the spermatic cyst after the ligations and those which did not. These observations suggest that the sperm stasis would affect the testicular function.Vasectomy or vasoligation is not necessarily an adequate procedure for the investigation of sperm stasis, because postoperative formation of the spermatic cyst and absorptive function of the epididymis would influence the results. The purpose of this investigation is to study the effect of sperm stasis on the testicular function by means of the ligation at three different locations of the ductal system; namely, vas deferens, corpus epididymidis and vasa efferentia.

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Gonadal Effects of Vasectomy and Vasoligation

Cited by 69 publications

References 20 publications

The Effect of Hemicastration on Daily Sperm Output in the Rat as Measured by a New Method

The Effect of Hemicastration on Daily Sperm Output in the Rat as Measured by a New Method

Testicular Injection of 5,6-Dihydroxytryptamine or Vasectomy Interferes with the Local Stimulatory Effect of Oxytocin on Testicular Steroidogenesis in Immature Rats

The Effects of Ligation of Vas Deferens, Corpus Epididymidis and Vasa Efferentia on the Testicular Function in Rats

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