Gonadal dysfunction and fertility problems in cancer survivors

Brydøy, Marianne; Fosså, Sophie D.; Dahl, Olav; Bjøro, Trine

doi:10.1080/02841860601166958

Cited by 116 publications

(66 citation statements)

References 79 publications

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“…2) (39). These observations are most likely secondary effects caused by a therapy-associated decrease in gonadal functionality (40,41,42,43). As untreated male hypogonadism (frequently observed following cranial irradiation) is a major risk factor for the development of premature osteoporosis, this may be one explanation for the high prevalence of this disorder in male long-term cancer survivors.…”

Section: Clinical Study J Gebauer E-m Fick and Others Endocrine Latementioning

confidence: 99%

Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Gebauer

Fick

Waldmann

et al. 2015

European Journal of Endocrinology

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Objective: Due to the increasing success and survival rates in the primary treatment of malignancies derived from the CNS as well as the hematopoietic system, endocrine late effects of cancer and its therapy are of growing importance. Despite evaluation of these late effects in patients treated for cancer in childhood, the impact on adults remains largely unclear. Methods: 1035 adult patients primarily diagnosed with a CNS malignancy, a Hodgkin (HL) or non-Hodgkin lymphoma (NHL) between 1998 and 2008 were recruited via the regional epidemiological cancer registry covering w2.8 million inhabitants in the federal state of Schleswig-Holstein, Northern Germany. The prevalence of endocrine disorders and current psychosocial impairment was assessed employing several questionnaires (SF-36v1, WHO-5). Results: Fully completed questionnaires of 558 patients were available for subsequent analysis showing markedly reduced overall performance and psychological status when compared to German reference data. Thyroid disorders were reported in 16.3% of patients with 10.4% suffering from hypo-and 5.9% from hyperthyroidism. Overall, 17.6% stated to be affected by diabetes mellitus with an increased rate of 21.1% among NHL patients and 11.5% of participants were affected by osteoporosis. Conclusion: Compared to German population based studies on the prevalence of diabetes mellitus, osteoporosis and thyroid disorders the frequency of all these endocrine problems was significantly increased in CNS, HL, and NHL cancer survivors. These data confirm that not only children and adolescents but also adult cancer patients are at risk for therapy associated endocrine late effects.

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Section: Clinical Study J Gebauer E-m Fick and Others Endocrine Latementioning

confidence: 99%

Self-reported endocrine late effects in adults treated for brain tumours, Hodgkin and non-Hodgkin lymphoma: a registry based study in Northern Germany

Gebauer

Fick

Waldmann

et al. 2015

European Journal of Endocrinology

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show abstract

“…Due to the increased sensitivity of germ cells to radiation and chemotherapy compared with that of Leydig cells, reduced fertility is considered to be a more common complication than hypogonadism following such treatments. Therefore, all patients should be advised to undergo sperm cryopreservation prior to any cytotoxic or radiation treatment (Brydøy et al 2007). …”

Section: Gonadal Toxicitymentioning

confidence: 99%

Endocrinopathies in Male Infertility

2010

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“…Another reason for higher resistance of ovaries of prepubertal girls to ChT is their greater follicular reserve when compared with the ovaries of adults (Chemaitilly et al 2006, Grigg et al 2000. Among chemotherapeutic agents, alkylating agents, which prevent cell division by interacting with DNA, are known to be associated with the occurrence of ovarian failure (Brydøy et al 2007, Chematilly et al 2006, Green et al 2009, Ortin et al 1990, Zacharin et al 2010, ovarian failure being dependent on the cumulative dose of cytostatic and age of patients during treatment. In CCSS-study, it was reported that alkylating agents cyclophosphamide and procarbazine were significant risk factors for ovarian failure (Chematilly et al 2006).…”

Section: Toxic Effects Of Cytostatic Agents On Ovariesmentioning

confidence: 99%