Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

Yaqoob, Sundas Bahar; Adnan, Rohana; Khan, Raja Muhammad Rameez; Rashid, Mohd

doi:10.3389/fchem.2020.00376

Cited by 187 publications

(85 citation statements)

References 153 publications

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“…Silver nanoparticles (AgNPs), which possess unique catalytic, electric, and antibacterial properties, arguably constitute the most common and widely used nanoparticulate material. 1 , 2 Their use is particularly promoted by their antibacterial properties. AgNPs effectively suppress the growth of pathogenic unicellular microorganisms and viruses of various taxonomic groups.…”

Section: Introductionmentioning

confidence: 99%

Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover

Skomorokhova¹,

Sankova²,

Orlov³

et al. 2020

NSA

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The ability of silver nanoparticles (AgNPs) of different sizes to influence copper metabolism in mice is assessed. Materials and Methods: AgNPs with diameters of 10, 20, and 75 nm were fabricated through a chemical reduction of silver nitrate and characterized by UV/Vis spectrometry, transmission and scanning electronic microscopy, and laser diffractometry. To test their bioactivity, Escherichia coli cells, cultured A549 cells, and C57Bl/6 mice were used. The antibacterial activity of AgNPs was determined by inhibition of colony-forming ability, and cytotoxicity was tested using the MTT test (viability, %). Ceruloplasmin (Cp, the major mammalian extracellular copper-containing protein) concentration and enzymatic activity were measured using gel-assay analyses and WB, respectively. In vitro binding of AgNPs with serum proteins was monitored with UV/Vis spectroscopy. Metal concentrations were measured using atomic absorption spectrometry. Results: The smallest AgNPs displayed the largest dose-and time-dependent antibacterial activity. All nanoparticles inhibited the metabolic activity of A549 cells in accordance with dose and time, but no correlation between cytotoxicity and nanoparticle size was found. Nanosilver was not uniformly distributed through the body of mice intraperitoneally treated with low AgNP concentrations. It was predominantly accumulated in liver. There, nanosilver was included in ceruloplasmin, and Ag-ceruloplasmin with low oxidase activity level was formed. Larger nanoparticles more effectively interfered with the copper metabolism of mice. Large AgNPs quickly induced a drop of blood serum oxidase activity to practically zero, but after cancellation of AgNP treatment, the activity was rapidly restored. A major fraction of the nanosilver was excreted in the bile with Cp. Nanosilver was bound by alpha-2-macroglobulin in vitro and in vivo, but silver did not substitute for the copper atoms of Cp in vitro. Conclusion:The data showed that even at low concentrations, AgNPs influence murine copper metabolism in size-dependent manner. This property negatively correlated with the antibacterial activity of AgNPs.

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Section: Introductionmentioning

confidence: 99%

Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover

Skomorokhova¹,

Sankova²,

Orlov³

et al. 2020

NSA

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“…These methods are effective in cancer treatment but are associated with many disadvantages. The relevance of nanotechnology in cancer therapy is from the early detection and analysis of tumors [86]. The studies on MNPs for cancer therapy are related to exploring the advantage of nanotechnology.…”

Section: Anticancer Activitymentioning

confidence: 99%

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair¹,

Morsy²,

Shinu³

et al. 2021

J Pharm Pharm Sci

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Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many reviews on iron MNPs for biomedical application. Hence, in this review, we focus on non-iron MNPs and their vivid biomedical applications. Here, we review the applications of non-iron MNPs in biomedicine such as drug delivery, gene delivery, anticancer activity, antimicrobial activity, tissue engineering, bioimaging, and photodynamic, and photothermal therapies.

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“…Drug-loaded gold NPs (AuNPs) aimed at intracellular inhibition mechanisms of viral activities. AuNPs should interact with virus particles to demonstrate better antiviral actions, through inhibiting viral entry (Yaqoob et al 2020). For instance, using AuNPs for delivery of antiviral peptide "FluPep" improved its solubility and resulted in a synergistic anti-viral potential against influenza virus (Zaid et al 2018).…”

Section: Gold Nps (Au Nps)mentioning

confidence: 99%

A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19)

Fouad

2021

Bull Natl Res Cent

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Background Over the last ten months since December 2019, the world has faced infectious emerging novel coronavirus disease-2019 (COVID-19) outbreaks that had a massive global impact affecting over 185 countries. Main body Emerging novel COVID-19 is a global health emergency on a pandemic scale that represents a terror to human health through its ability to escape anti-viral measures. Such viral infections impose a great socioeconomic burden, besides global health challenges. This imposes a pressing need for the development of anti-viral therapeutic agents and diagnostic tools that demonstrate multifunctional, target-specific, and non-toxic properties. Nanotheranostics is regarded as a promising approach for the management of different viral infections. Nanotheranostics facilitates targeted drug-delivery of anti-viral therapeutics as well as contributing to the development of diagnostic systems. Multifunctional metallic nanoparticles (NPs) have emerged as innovative theranostic agents that enable sustainable treatment and effective diagnosis. Here we have reviewed current advances in the use of theranostic metallic NPs to fight against COVID-19, and discussed the application as well as limitations associated with nanotechnology-based theranostic approaches. Conclusion This review verified the potential use of some metal-based NPs as anti-viral nanotheranostic agents. Metal-based NPs could act as carriers that enable the sustainable and targeted delivery of active anti-viral molecules, or as diagnostic agents that allow rapid and sensitive diagnosis of viral infections.

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Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications

Cited by 187 publications

References 153 publications

Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover

Size-Dependent Bioactivity of Silver Nanoparticles: Antibacterial Properties, Influence on Copper Status in Mice, and Whole-Body Turnover

Advances of Non-Iron Metal Nanoparticles in Biomedicine

A proposed insight into the anti-viral potential of metallic nanoparticles against novel coronavirus disease-19 (COVID-19)

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