Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair, Anroop B.; Morsy, Mohamed A.; Shinu, Pottathil; Chandrasekaran, Mithra; Tahir, Abu

doi:10.18433/jpps31434

Cited by 12 publications

(21 citation statements)

References 106 publications

(146 reference statements)

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“…Metal NPs-mainly gold, but also silver-maybe considered among the "gold standards" in nanomaterials through the history and expansion of nanosciences in terms of dedicated publications and vastness of related possible applications [123]. As already well documented for Au and Ag NPs, the reasons are numerous and reside notably in their relatively easy accessibility with low-cost and highly reproducible (large scale) biogenic and chemical synthetic routes, in addition to the flexibility to finely tailor the properties via a refined size and shape control (with narrow size distribution and diverse shapes), and the facility for functionalization with various types of molecules.…”

Section: Metal Npsmentioning

confidence: 99%

“…Consequently, not only can these nano building blocks carry PS molecules and alter the integrity of microbial walls/membranes or gene expression, but they may as well act as PSs; when coupled with other PSs, synergistic interactions in the QD-PS edifices might occur resulting from mechanisms such as Förster resonance energy transfer (FRET, non-radiative energy transfer from QD donors to PS acceptors) to generate free radicals and ROS. Among examples of such QDs and metal chalcogenide aPDT systems can be cited CdTe QDs and related CdTe-PS conjugates, CdSe/ZnS QDs combined with PSs, InP and InP-PS, Mn-doped ZnS, MoS 2 , but also CuS and CdS nanocrystals, with ultimately hybrid systems involving for instance CoZnO/MoS 2 or AgBiS 2 -TiO 2 composites [123,[183][184][185][186][187][188][189][190][191][192][193][194][195][196].…”

Section: Qds and Metal Chalcogenide Nanomaterialsmentioning

confidence: 99%

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Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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Section: Metal Npsmentioning

confidence: 99%

Section: Qds and Metal Chalcogenide Nanomaterialsmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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“…Nanoparticles can be classified into 2 categories: organic and inorganic NPs. Metallic NPs are listed as inorganic NPs; however, liposomes, micelles, dendrimers, and polymeric NPs are considered organic NPs ( 69 ) ( Table 4 ).…”

Section: Nanocarrier Mediated Treatment Of Triple Negative Breast Cancermentioning

confidence: 99%

A Review on Nanocarrier Mediated Treatment and Management of Triple Negative Breast Cancer: A Saudi Arabian Scenario

et al. 2022

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People have continued to be petrified by the devastating effects of cancer for decades and thus a pursuit for developing anticancer agents have seen an ever-increasing trend in the past few decades. Globally, breast cancer is the most common malignancy in women and the second most common cause of cancer-related deaths. In Saudi Arabia, breast cancer is the most common type of cancer among women, constituting almost 14.2% of the total cancer burden. Triple-negative breast cancer (TNBC) is a subtype of breast cancer, which is a pathologically diverse disease of higher grade characterized by the absence of the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2) expressions. Despite the considerable advancements achieved in the therapeutic management of cancer, TNBC remains an unbeatable challenge, which requires immediate attention as it lacks conventional targets for treatment, leading to a poor clinical prognosis. The present research goals are directed toward the development and implementation of treatment regimens with enhanced bioavailability, targetability, minimized systemic toxicity, and improved outcomes of treatment options. The present treatment and management scenario of TNBC continues to provoke oncologists as well as nanomedical scientists to develop novel and efficient nanotherapies. Lately, scientific endeavors have addressed the importance of enhanced availability and targeted cellular uptake with minimal toxicity, which are achieved by the application of nano drug-carriers. This review intends to summarize the incidence rates of TNBC patients, the importance of nanotherapeutic options for patients suffering from TNBC, the identification of promising molecular targets, and challenges associated with the development of targeted nanotherapeutics with special reference to the Saudi Arabian context.

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“…Fluorescent nanoparticles (NPs) have been widely used in environment and biomedical areas such as chemical detection, bioimaging, − and biosensors based on their unique size-related properties, such as good penetrability and high specific surface area. Compared with organic NPs, inorganic fluorescent NPs, which include metal NPs, semiconductor NPs, carbon dots, etc., usually have advantages such as narrow emission bands, high emission intensity, and more stable luminescence .…”

Section: Introductionmentioning

confidence: 99%

Sol–Gel-Derived Biodegradable Er-Doped ZnO/Polyethylene Glycol Nanoparticles for Cell Imaging

Chen

Xue

Luo

et al. 2022

ACS Appl. Nano Mater.

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Zinc oxide nanoparticles (ZnO NPs) as promising and nontoxic fluorescent labels are currently developed for cell imaging owing to their excellent biocompatibility. However, the low intensity of the emission band and stability of ZnO NPs have restricted their further applications. In this work, 5 mol % rare-earth metal erbium (Er)-doped ZnO nanoparticles with poly(ethylene glycol) (PEG) surface modification (Er-doped ZnO/PEG NPs) are fabricated by the sol–gel method. Their fluorescence characteristics and biodegradation behavior are investigated. The results indicate that the visible photoluminescence of Er-doped ZnO/PEG NPs has been dramatically enhanced by 631.6% compared with that of bare ZnO NPs. After being stored for one month, particle size variation is less than 1 nm, and fluorescence performance can be well retained. Furthermore, the degradation and cytotoxicity results confirm the degradable and biocompatible characteristics of Er-doped ZnO/PEG NPs, thus extending their potential applications for cell imaging.

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Advances of Non-Iron Metal Nanoparticles in Biomedicine

Cited by 12 publications

References 106 publications

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

A Review on Nanocarrier Mediated Treatment and Management of Triple Negative Breast Cancer: A Saudi Arabian Scenario

Sol–Gel-Derived Biodegradable Er-Doped ZnO/Polyethylene Glycol Nanoparticles for Cell Imaging

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