Gold Nanorod Integrated Electrochemical Sensing for Hyperglycaemia on Interdigitated Electrode

Zheng, Suiping; Zhang, Hong; Lakshmipriya, Thangavel; Gopinath, Subash C. B.; Yang, Na

doi:10.1155/2019/9726967

Cited by 27 publications

(23 citation statements)

References 34 publications

(34 reference statements)

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“…CDI-functionalized surfaces exhibit imidazole carbamate functionality, producing a stable carbamate linkage with an amine group. CDI is commonly utilized to immobilize proteins or antibodies on sensing surfaces [38, 39]. In this study, streptavidin was placed on the CDI-modified surface, inducing a current level increment to 1.48E−07 A, clearly indicating the binding of streptavidin to the biotinylated probe on the surface.…”

Section: Resultsmentioning

confidence: 94%

Aluminum Microcomb Electrodes on Silicon Wafer for Detecting Val66Met Polymorphism in Brain-Derived Neurotrophic Factor

Li¹,

Cui²,

Zhao³

et al. 2021

Dev Neurosci

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Objective: Brain-derived neurotrophic factor (BDNF) dysregulation is widely related with various psychiatric and neurological disorders, including schizophrenia, depression, Rett syndrome, and addiction, and the available evidence suggests that BDNF is also highly correlated with Parkinson’s and Alzheimer’s diseases. Methods: The BDNF target sequence was detected on a capture probe attached on aluminum microcomb electrodes on the silicon wafer surface. A capture-target-reporter sandwich-type assay was performed to enhance the detection of the BDNF target. Results: The limit of detection was noticed to be 100 aM. Input of a reporter sequence at concentrations >10 aM improved the detection of the target sequence by enhancing changes in the generated currents. Control experiments with noncomplementary and single- and triple-mismatches of target and reporter sequences did not elicit changes in current levels, indicating the selective detection of the BDNF gene sequence. Conclusion: The above detection strategy will be useful for the detection and quantification of BDNF, thereby aiding in the provision of suitable treatments for BDNF-related disorders.

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Section: Resultsmentioning

confidence: 94%

Aluminum Microcomb Electrodes on Silicon Wafer for Detecting Val66Met Polymorphism in Brain-Derived Neurotrophic Factor

Li¹,

Cui²,

Zhao³

et al. 2021

Dev Neurosci

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“…2c). This dielectric IDE is a well-accepted system that has been widely used for different biomolecular and chemical analyses [15,[25][26][27][28]. In this study, all the surface chemical modifications and interactive analyses were measured by the I-V current mode.…”

Section: Fabrication Of the Ide Sensor And Surface Analysismentioning

confidence: 99%

Detection of microRNA-335-5p on an Interdigitated Electrode Surface for Determination of the Severity of Abdominal Aortic Aneurysms

Liu

Wang

et al. 2020

Nanoscale Res Lett

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Abdominal aortic aneurysm (AAA) refers to the enlargement of the lower artery of the abdominal aorta, and identification of an early detection tool is urgently needed for diagnosis. In the current study, an interdigitated electrode (IDE) sensing surface was used to identify miRNA-335-5p, which reflects the formation of AAAs. The uniformity of the silica material was observed by 3D profilometry, and the chemically modified highly conductive surface improved the detection via the I-V mode. The targeted miRNA-335-5p was detected in a dose-dependent manner and based on linear regression and 3σ analyses, the sensitivity was determined to be 1 fM with a biotinylated probe. The high specificity was shown by discriminating the target sequence from noncomplementary and single-and triple-mismatched sequences. These outputs demonstrated the high-performance detection of miRNA-335-5p with good reproducibility for determination of the severity of AAA.

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“…Gold nanoparticles (AuNPs) attract much attention owing to their unique optical, electronic, and catalytic properties. They have allowed development of different prototypes of devices for sensing [1,2], detecting [3], and imaging [4,5]. Further progress in designing AuNP-based devices depends on the ability to fabricate complex assemblies with tailored optoelectronic properties.…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoparticle Self-Aggregation on Surface with 1,6-Hexanedithiol Functionalization

et al. 2020

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Here we study the morphology and the optical properties of assemblies made of small (17 nm) gold nanoparticles (AuNPs) directly on silicon wafers coated with (3-aminopropyl)trimethoxysilane (APTES). We employed aliphatic 1,6-hexanedithiol (HDT) molecules to cross-link AuNPs during a two-stage precipitation procedure. The first immersion of the wafer in AuNP colloidal solution led mainly to the attachment of single particles with few inclusions of dimers and small aggregates. After the functionalization of precipitated NPs with HDT and after the second immersion in the colloidal solution of AuNP, we detected a sharp rise in the number of aggregates compared to single AuNPs and their dimers. The lateral size of the aggregates was about 100 nm, while some of them were larger than 1μm. We propose that the uncompensated dipole moment of the small aggregates appeared after the first precipitation and acts further as the driving force accelerating their further growth on the surface during the second precipitation. By having such inhomogeneous surface coating, the X-ray reciprocal space maps and modulation polarimetry showed well-distinguished signals from the single AuNPs and their dimers. From these observations, we concluded that the contribution from aggregated AuNPs does not hamper the detection and investigation of plasmonic effects for AuNP dimers. Meantime, using unpolarized and polarized light spectroscopy, the difference in the optical signals between the dimers, being formed because of self-aggregation and the one being cross-linked by means of HDT, was not detected.

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Gold Nanorod Integrated Electrochemical Sensing for Hyperglycaemia on Interdigitated Electrode

Cited by 27 publications

References 34 publications

Aluminum Microcomb Electrodes on Silicon Wafer for Detecting Val66Met Polymorphism in Brain-Derived Neurotrophic Factor

Aluminum Microcomb Electrodes on Silicon Wafer for Detecting Val66Met Polymorphism in Brain-Derived Neurotrophic Factor

Detection of microRNA-335-5p on an Interdigitated Electrode Surface for Determination of the Severity of Abdominal Aortic Aneurysms

Gold Nanoparticle Self-Aggregation on Surface with 1,6-Hexanedithiol Functionalization

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