Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

Abstract

Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS2 NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS2 NSs (MoS2@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS2@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS2@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS2@AuNRs were confirmed against E. coli by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS2@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS2@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections.

High-Efficiency Near-Infrared Light Responsive Antibacterial System for Synergistic Ablation of Bacteria and Biofilm

“…17−19 Because of its advantages of fast, noninvasive, and remote control, it has excellent application prospects in treating drug-resistant bacterial infection and dissipation of biofilm. 20−23 At present, there are many antibacterial agents based on PTT, including graphene oxide (Go), 24 black phosphorus, 25 molybdenum disulfide, 26 and so on. Among them, the photothermal conversion mechanism due to the localized surface plasmon resonance (LSPR) effect makes Ti 3 C 2 T x have a high extinction coefficient (ε) and high photothermal conversion efficiency (η), 27 which indicates the remarkable advantages of emerging Ti 3 C 2 T x used as photothermal agents, even superior to most of the inorganic photothermal agents in the literature.…”

“…Antibacterial photothermal therapy (PTT) is a treatment that uses photothermal materials to convert near-infrared into local heat to kill bacteria. − Because of its advantages of fast, noninvasive, and remote control, it has excellent application prospects in treating drug-resistant bacterial infection and dissipation of biofilm. − At present, there are many antibacterial agents based on PTT, including graphene oxide (Go), black phosphorus, molybdenum disulfide, and so on. Among them, the photothermal conversion mechanism due to the localized surface plasmon resonance (LSPR) effect makes Ti 3 C 2 T x have a high extinction coefficient (ε) and high photothermal conversion efficiency (η), which indicates the remarkable advantages of emerging Ti 3 C 2 T x used as photothermal agents, even superior to most of the inorganic photothermal agents in the literature. , Moreover, Ti 3 C 2 T x has some other excellent properties, such as biocompatibility, large specific surface area, abundant active sites, and good antibacterial properties, making it the perfect choice for an antibacterial PTT system.…”

Gold Nanorods for Doxorubicin Delivery: Numerical Analysis of Electric Field Enhancement, Optical Properties and Drug Loading/Releasing Efficiency

“…It is usual to apply citric acid for the reduction of gold salts to NPs [ 17 ]. Collective oscillations occur when free electrons in nanoparticles receive energy from light [ 18 ]. The absorbed light induces heat inside the nanoparticles because the absorption cross-section of AuNPs is large at the plasmon resonance frequency [ 19 ].…”

Inhibition of cancer cells using target-specific 2A3 antibody-conjugated gold nanoclusters

“…Recent advancements of nanomaterials have been focused on applications in nanomedicine and nanotechnology based on their outstanding chemical and physical properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Among these nanomaterials, metal nanoclusters (NCs) composed of several to hundreds of metal atoms with unique structural and optical characteristics have been extensively demonstrated for the research fields in imaging, detection, and therapy [15][16][17].…”