Gold nanoplates with superb photothermal efficiency and peroxidase-like activity for rapid and synergistic antibacterial therapy

Abstract

Gold nanoplates exhibit 68.5% photothermal conversion efficiency and peroxidase-like activity, and AuNPTs (50 μg mL−1)/H2O2 (0.1 mM)/NIR (1 W cm−2, 3 min) show excellent synergistic antibacterial ability and promote MRSA-infected wound healing in vivo.

Advances in Nanostructures for Antimicrobial Therapy

“…In an in vivo study using an implant biofilm infection model irradiation with 0.5 W/cm 2 NIR lasting 5 min caused considerable acceleration of NO release, damaged MRSA biofilms and killed planktonic MRSA missing its biofilm protection [ 295 ]. Outstanding synergistic antibacterial ability and cure of MRSA-infected wounds in vivo was observed with 50 μg/mL Au nanoplates combined with 0.1 mM H 2 O 2 under irradiation with 808 nm laser (1 W/cm 2 ) for 3 min [ 296 ].…”

Efficient nanozyme engineering for antibacterial therapy

“…To date, with the rapid development of nanotechnology, a large number of antibacterial nanozymes have been developed, from noble-metal (e.g. Au [19][20][21][22][23][24][25][26], Pt [27], Cu [28], Ir [29], Ag [30], Au-Pt [31,32], Pd-Cu [33], Pd-Pt [34], Au-Ag [35], etc), transition metal oxide or sulfide (e.g. Fe 3 O 4 [36][37][38], CuO [39], CeO 2 [40], V 2 O 5 [41], Co-V mixed metal oxide (MMO) [42], MoS 2 [43][44][45][46][47], NiS 2 [48], CuS [49][50][51][52], Co 4 S 3 [53], MnO 2 [54] etc), and nanocarbon (e.g.…”

“…The photothermal nanoagents can absorb the NIR and convert the optical energy into heat, which then initiates the cell membrane breakage and protein denaturation in bacteria, finally leading to their thermal ablation [102][103][104]. Based on this, NIR-responsive nanozymes, such as Au nanoplates [26], Au@Pt nanodots [32], Au NRs/CeO 2 hybrid [91], rough carbon/Fe 3 O 4 nanohybrids [102], cationic chitosan@RuO 2 hybrid [105], MoS 2 nanozymes [43,82,106], N-doped carbon nanozyme [55], PEG@Zr-Fc MOF hydrogel [107], and Fe-and Cu-N-C SAzymes [61,63,64], have been developed. Under the NIR laser irradiation, these NIR-active nanozymes can not only produce local photothermal effect, but more importantly the elevated temperature certainly accelerates catalytic reaction rate, thereby realizing the enhanced synergic CDT and PTT for effectively treating drug-resistant bacterial infections.…”

Completely green synthesis of rose-shaped Au nanostructures and their catalytic applications

“…Because the chemical and physical properties of gold (Au) nanocrystals depend heavily on their size and shape, the sizeand shape-controlled synthesis of Au nanocrystals is an important topic. 1,2 The literature includes numerous reports of the synthesis of Au nanocrystals with various shapes, including zero-dimensional (0D, such as spheres and platonic shapes), 3,4 one-dimensional (1D, such as rods and nanowires), 5,6 twodimensional (2D, such as plates and sheets), 7,8 and threedimensional (3D, such as multipods and nanocages). 9,10 Among the various reported structures, Au nanocrystals with 3D hierarchical structures such as ower-like architectures have attracted considerable attention because of their unique structural features, which include a high surface roughness, a large surface area-to-volume ratio, and abundant edges and sharp tips.…”