Gold nanoparticles with different charge and moiety induce differential cell response on mesenchymal stem cell osteogenesis

Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

“…Gold nanoparticles synthesized with different charges using amine, carboxyl and hydroxyl groups were studied for its differential cell response on hMSCs osteogenesis. Surface functionalized gold nanoparticles treated with hMSCs showed better osteogenic differentiation, cellular uptake and cell viability with no acute toxicity[60].Kumar et al developed hybrid nanoparticle consisting of strontium decorated with reduced graphene oxide to demonstrate their use in bone tissue formation. The hybrid nanoparticles of size 200-300 nm were then incorporated in PCL scaffolds to improve the osteogenic differentiation process in bone tissue regeneration.…”

Nanotechnology for mesenchymal stem cell therapies

“…A possible explanation for the alteration observed compared to control groups can be found in the surface changes induced on MSC by the presence of COOH-functional groups, as for example the different arrangements in the specific binding of integrin receptors on the cell surface [72]. Such induction, however, did not affect cell osteogenic potential, thus suggesting this system as a good ex vivo cell expansion platform [73].…”

Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells

“…11 Recently, AuNPs have been extensively employed as emerging therapeutic agents for the treatment of AIDS, 12 Parkinson's disease, 13 and diabetes, 14 or controlling neural stem/progenitor cell renewal 15 and promoting osteogenic differentiation of mesenchymal stem cells. [16][17][18] Furthermore, AuNPs are also exploited as a novel class of antitumor agents in cancer therapy through inhibiting angiogenesis and ablating the tumor microvasculature, 19 enhancing chemosensitivity of cancer cells by reversing epithelial-mesenchymal transition, 20 preventing tumor growth and metastasis via abrogating growth factor signaling cascades, 21 and boosting the antitumor immune response as a vaccine platform. 22 These results strongly demonstrate that AuNPs may serve as self-therapeutic nanoparticles in cancer treatment.…”