Gold nanoparticles paper as a SERS bio-diagnostic platform

Ngo, Ying Hui; Then, Whui Lyn; Shen, Wei; Garnier, Gil

doi:10.1016/j.jcis.2013.07.051

Cited by 44 publications

(30 citation statements)

References 23 publications

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“…The particles are retained within the filter's matrix via adsorption due to van der Waals forces and hydrophobic interactions between the nanoparticles and fibers [196]. Groups such as Cheng et al, Liu et al, and Ngo et al have utilized this technique to detect tyrosine [197], oral cancer cells [198], and antigen [199], respectively. Cheng et al reported that the use of filter paper to detect tyrosine provided 50 times more SERS signal and a detection limit of 625 nm [197].…”

Section: Dip Coating Paper-based Sersmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

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Point-of-care (POC) device development is a growing field that aims to develop low-cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, selfcontained, and can be used anywhere -from modern clinics to remote and low resource areas. In this review, surface enhanced Raman spectroscopy (SERS) is discussed as a solution to facilitating the translation of bioanalytical sensing to the POC. The potential for SERS to meet the widely accepted "ASSURED" (Affordable, Sensitive, Specific, Userfriendly, Rapid, Equipment-free, and Deliverable) criterion provided by the World Health Organization is discussed based on recent advances in SERS in vitro assay development. As SERS provides attractive characteristics for multiplexed sensing at low concentration limits with a high degree of specificity, it holds great promise for enhancing current efforts in rapid diagnostic testing. In outlining the progression of SERS techniques over the past years combined with recent developments in smart nanomaterials, high-throughput microfluidics, and low-cost paper diagnostics, an extensive number of new possibilities show potential for translating SERS biosensors to the POC.

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Section: Dip Coating Paper-based Sersmentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS) for in vitro diagnostic testing at the point of care

et al. 2017

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“…Due to their intrinsic characteristics, AuNPs have been incorporated in the development of a number of bio-applications over the years [109][110][111][112][113]. It is, however, evident that in their incorporation into monolithic adsorbents and applications, surface modification are primarily preferred over copolymerisation approaches [92].…”

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Nano-Doped Monolithic Materials for Molecular Separation

et al. 2017

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Monoliths are continuous adsorbents that can easily be synthesised to possess tuneable meso-/macropores, convective fluid transport, and a plethora of chemistries for ligand immobilisation. They are grouped into three main classes: organic, inorganic, and hybrid, based on their chemical composition. These classes may also be differentiated by their unique morphological and physicochemical properties which are significantly relevant to their specific separation applications. The potential applications of monoliths for molecular separation have created the need to enhance their characteristic properties including mechanical strength, electrical conductivity, and chemical and thermal stability. An effective approach towards monolith enhancement has been the doping and/or hybridization with miniaturized molecular species of desirable functionalities and characteristics. Nanoparticles are usually preferred as dopants due to their high solid phase dispersion features which are associated with improved intermolecular adsorptive interactions. Examples of such nanomaterials include, but are not limited to, carbon-based, silica-based, gold-based, and alumina nanoparticles. The incorporation of these nanoparticles into monoliths via in situ polymerisation and/or post-modification enhances surface adsorption for activation and ligand immobilisation. Herein, insights into the performance enhancement of monoliths as chromatographic supports by nanoparticles doping are presented. In addition, the potential and characteristics of less common nanoparticle materials such as hydroxyapatite, ceria, hafnia, and germania are discussed. The advantages and challenges of nanoparticle doping of monoliths are also discussed.

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“…Gold nanoparticles (AuNPs) have been widely studied and applied in many sensing application of inorganic ions [8] and biological analytes such as amino acids, peptides, proteins, and DNA fragments [9][10][11][12][13]. The optical properties of AuNPs enable their use for colorimetric transduction of molecular interactions simply by standard UV-Vis spectrometer or even by the naked eye [14][15].…”

Section: Introductionmentioning

confidence: 99%