Gold Nanoparticles Incorporated with Cyclodextrins and Its Applications

Abdulaziz, Fahad; Salah, Dina

doi:10.4236/jbnb.2021.124007

Cited by 3 publications

(4 citation statements)

References 51 publications

(46 reference statements)

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“… 8 , 15 Therefore, CDs can provide a favorable environment for the inclusion of complex formation with hydrophobic organic bioactive compounds in different drug:CD ratios (1:1, 1:2, or 2:1). 16 , 17 …”

Section: Ability Of Cyclodextrin To Form Inclusion Complexesmentioning

confidence: 99%

“…AuNPs are the most stable, fascinating, and attractive metal nanoparticles for nanotechnological research because of their stability, uniformity, biocompatibility, etc, 17 , 116 , 117 and also for their optical, electronic, magnetic, and supramolecular properties. 118 , 119 Additionally, AuNPs can conjugate many biological substances and form active complexes to provide targeted drug delivery.…”

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

“…Consequently, the large surface area allowed better contact of AuNPs containing the bioactive molecules with the biological membranes and improved their bioavailability. 17 , 20 , 121 , 122 Regarding their application in medicine, AuNPs are utilized for the early detection and diagnosis of different diseases, as well as in their treatment. 123 , 124 …”

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

“…Several AuNPs-capped CDs have been reported by different groups for application in gene delivery. 17 , 233 , 234 These studies focus on the construction and characterization of CD-AuNPs. The utilization of cyclodextrin-containing cross-linked matrixes for DNA aggregation has been established and reported by Davis and coworkers.…”

Section: Impact Of β-Cd On Aunps Properties and Applicationsmentioning

confidence: 99%

See 3 more Smart Citations

Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles

Abdellatif¹,

Ahmed²,

Mohammed³

et al. 2023

IJN

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The real problem in pharmaceutical preparation is drugs’ poor aqueous solubility, low permeability through biological membranes, and short biological t 1/2 . Conventional drug delivery systems are not able to overcome these problems. However, cyclodextrins (CDs) and their derivatives can solve these challenges. This article aims to summarize and review the history, properties, and different applications of cyclodextrins, especially the ability of inclusion complex formation. It also refers to the effects of cyclodextrin on drug solubility, bioavailability, and stability. Moreover, it focuses on preparing and applying gold nanoparticles (AuNPs) as novel drug delivery systems. It also studies the uses and effects of cyclodextrins in this field as novel drug carriers and targeting devices. The system formulated from AuNPs linked with CD molecules combines the advantages of both CD and AuNPs. Cyclodextrins benefit in increasing aqueous drug solubility, loading capacity, stability, and size control of gold NPs. Also, AuNPs are applied as diagnostic and therapeutic agents because of their unique chemical properties. Plus, AuNPs possess several advantages such as ease of detection, targeted and selective drug delivery, greater surface area, high loading efficiency, and higher stability than microparticles. In the present article, we tried to present the potential pharmaceutical applications of CD-derived AuNPs in biomedical applications including antibacterial, anticancer, gene-drug delivery, and various targeted drug delivery applications. Also, the article highlighted the role of CDs in the preparation and improvement of catalytic enzymes, the formation of self-assembling molecular print boards, the fabrication of supramolecular functionalized electrodes, and biosensors formation.

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Section: Ability Of Cyclodextrin To Form Inclusion Complexesmentioning

confidence: 99%

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Section: Gold Nanoparticles (Aunps)mentioning

confidence: 99%

Section: Impact Of β-Cd On Aunps Properties and Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles

Abdellatif¹,

Ahmed²,

Mohammed³

et al. 2023

IJN

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The effect of size control of Gold Nanoparticles Stabilized with α-cyclodextrin and β-cyclodextrin and their antibacterial activities

Hasanah¹,

Manurung²,

Jenie³

et al. 2023

Materials Chemistry and Physics

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Cyclodextrins: An Overview of Fundamentals, Types, and Applications

Yousaf¹,

Razzaq²,

Asghar³

et al. 2023

Cyclodextrins - Core Concepts and New Frontiers

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Cyclodextrins are one of the most interesting pharmaceutical excipients with substantial theoretical and applied impacts in pharmaceutical industry. Even though the chemical foundation of these macrocyclic molecules was laid more than 100 years ago by Villiers and Schardinger, it was not until recently that cyclodextrins have been regarded as a subject of numerous potential pharmaceutical applications including inclusion complexation. This particular chapter discusses the fundamental concepts of cyclodextrin chemistry, structure, properties, and host-guest interaction with a special focus on molecular dynamics. Further in this regard, applications of cyclodextrins and numerous drug delivery approaches including novel lipid-based nanosystems are also highlighted.

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Gold Nanoparticles Incorporated with Cyclodextrins and Its Applications

Cited by 3 publications

References 51 publications

Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles

Recent Advances in the Pharmaceutical and Biomedical Applications of Cyclodextrin-Capped Gold Nanoparticles

The effect of size control of Gold Nanoparticles Stabilized with α-cyclodextrin and β-cyclodextrin and their antibacterial activities

Cyclodextrins: An Overview of Fundamentals, Types, and Applications

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