Gold nanoparticles grafted modified silica gel as a new stationary phase for separation and determination of steroid hormones by thin layer chromatography

Amoli‐Diva, Mitra; Pourghazi, Kamyar

doi:10.1016/j.jfda.2014.11.005

Cited by 14 publications

(7 citation statements)

References 26 publications

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“…Due to its simplicity, this method is an attractive alternative to the traditional instrumental analysis of stanozolol-containing pharmaceutical preparations. An order of magnitude higher sensitivity was achieved for testosterone in a study that used a modification of silica gel with gold nanoparticles (AuNPs), where the LOD in urine reached 0.13 ng per spot at the linear range of 1–200 ng per spot [ 76 ].…”

Section: Standard Chromatographic Methods In Aas Determinationmentioning

confidence: 99%

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

Huml

Tauchen

Rimpelová

et al. 2021

Sensors

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Anabolic-androgenic steroids (AASs), a group of compounds frequently misused by athletes and, unfortunately, also by the general population, have lately attracted global attention; thus, significant demands for more precise, facile, and rapid AAS detection have arisen. The standard methods ordinarily used for AAS determination include liquid and gas chromatography coupled with mass spectrometry. However, good knowledge of steroid metabolism, pretreatment of samples (such as derivatization), and well-trained operators of the instruments are required, making this procedure expensive, complicated, and not routinely applicable. In the drive to meet current AAS detection demands, the scientific focus has shifted to developing novel, tailor-made approaches leading to time- and cost-effective, routine, and field-portable methods for AAS determination in various matrices, such as biological fluids, food supplements, meat, water, or other environmental components. Therefore, herein, we present a comprehensive review article covering recent advances in AAS determination, with a strong emphasis on the increasingly important role of chemically designed artificial sensors, biosensors, and antibody- and fluorescence-based methods.

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Section: Standard Chromatographic Methods In Aas Determinationmentioning

confidence: 99%

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

Huml

Tauchen

Rimpelová

et al. 2021

Sensors

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“…One study used this combination to carry out detection during the separation of fluorescent dyes such as melamine and Rhodamine 6G, with spatially‐resolved spectra being obtained by SERS along the direction of the separation that occurred on the UTLC plate . The same general approach was used to analyze polyaromatic hydrocarbons in cooking oils, giving a chip‐based technique that could be used for both sample cleanup and analysis . In addition, gold nanoparticles have been placed onto aminopropyl silica by Amoli‐Diva and Pourghazi for use in planar chromatography and the separation of steroids in human urine .…”

Section: Nanomaterials In Planar Liquid Chromatographymentioning

confidence: 99%

“…used gold nanoparticles that had been placed on commercial silica or alumina supports for TLC and modified with L‐cysteine as a chiral binding agent; these materials were used to separate chiral analytes such as tetrahydrozoline, hydroxyzine, ketoprofen, fenoprofen, pindolol, and fluoxetine . Arrays of silver nanorods have been employed by Chen and co‐workers as supports/stationary phases for UTLC and to aid in analyte detection by surface enhanced Raman spectroscopy (SERS) . One study used this combination to carry out detection during the separation of fluorescent dyes such as melamine and Rhodamine 6G, with spatially‐resolved spectra being obtained by SERS along the direction of the separation that occurred on the UTLC plate .…”

Section: Nanomaterials In Planar Liquid Chromatographymentioning

confidence: 99%

Nanomaterials as stationary phases and supports in liquid chromatography

et al. 2017

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The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the applications that have been explored for such systems. A number of carbon-based nanomaterials and inorganic nanomaterials have been considered for use in LC, ranging from carbon nanotubes, fullerenes and nanodiamonds to metal nanoparticles and nanostructures based on silica, alumina, zirconia and titanium dioxide. Many ways have been described for incorporating these nanomaterials into LC systems. These methods have included covalent immobilization, adsorption, entrapment, and the synthesis or direct development of nanomaterials as part of a chromatographic support. Nanomaterials have been used in many types of LC. These applications have included the reversed-phase, normal-phase, ion-exchange, and affinity modes of LC, as well as related methods such as chiral separations, ion-pair chromatography and hydrophilic interaction liquid chromatography. Both small and large analytes (e.g., dyes, drugs, amino acids, peptides and proteins) have been used to evaluate possible applications for these nanomaterial-based methods. The use of nanomaterials in columns, capillaries and planar chromatography has been considered as part of these efforts. Potential advantages of nanomaterials in these applications have included their good chemical and physical stabilities, the variety of interactions many nanomaterials can have with analytes, and their unique retention properties in some separation formats.

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“…Numerous articles have been published regarding the production of silica‐functionalized sorbent for separation and preconcentration of analytes. Among these sorbents with silica supported, surfactants, molecularly imprinted silica (MIS) , immunosorbents, magnetic materials (Fe 3 O 4 particles), nanostructured materials such as palladium, gold and silver and Schiff bases with chelating abilities have been employed in determination of analytes at trace levels. The retention capacity of the silica resin can be further increased through the modification procedures.…”

Section: Introductionmentioning

confidence: 99%

Silica Gel‐Immobilized 5‐aminoisophthalohydrazide: A novel sorbent for solid phase extraction of Cu, Zn and Pb from natural water samples

Aydın

Çakmak

Levent

et al. 2020

Applied Organom Chemis

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A novel silica sorbent, silica gel‐immobilized 5‐aminoisophthalohydrazide (SiO2‐APH), was prepared by the condensation of 3‐chloropropyl‐functionalized silica gel with 5‐aminoisophthalohydrazide (APH) derived from dimethyl 5‐aminoisophthalate as a starting material and used for separation and preconcentration of Cu, Zn, and Pb metals in water samples using Flame Atomic Absorption Spectrometry (FAAS). The characterization of the new sorbent was carried out by Elemental Analysis, Thermogravimetric Analysis (TGA) and Fourier Transform Infrared Spectroscopy (FTIR). Important analytical parameters including as pH, amount of sorbent, type and amount of eluting solvent, sample volume, vortex and ultrasonic bath time, matrix ions that effect the developed SiO2‐APH‐solid phase extraction (SPE) method were investigated and optimum parameters were detected. Recoveries of examined metals were obtained as 98% for Cu and Pb and 101% for Zn. The relative standard deviation (RSD, n = 8) of Cu, Zn and Pb metals were 3.2, 2.8 and 1.6%, respectively. Limit of detections (LODs) (n = 10) were found as 2.7 μg L−1 for Cu, 7.4 μg L−1 for Zn and 3.5 μg L−1 for Pb μg L−1. The accuracy of the new method was assessed by analyzing of TMDA‐51.4 and TMDA‐70.2 certified reference materials. The results obtained for metals were in a good agreement with certified values. Addition/recovery test was applied to the real well, river, dam and stream water samples to check the accuracy of the method. The results showed that the developed SiO2‐APH‐SPE method can be effectively used as an alternative method for determination of Cu, Zn, and Pb metals in water samples.

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Gold nanoparticles grafted modified silica gel as a new stationary phase for separation and determination of steroid hormones by thin layer chromatography

Cited by 14 publications

References 26 publications

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

Nanomaterials as stationary phases and supports in liquid chromatography

Silica Gel‐Immobilized 5‐aminoisophthalohydrazide: A novel sorbent for solid phase extraction of Cu, Zn and Pb from natural water samples

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