Gold nanoparticles-decorated graphene field-effect transistor biosensor for femtomolar MicroRNA detection

Cai, Bingjie; Huang, Le; Zhang, Hong; Sun, Zhongyue; Zhang, Zhiyong; Zhang, Guojun

doi:10.1016/j.bios.2015.06.068

Cited by 176 publications

(125 citation statements)

References 43 publications

(52 reference statements)

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…The sensing mechanism of FETs is illustrated in Figure 10C. Recent efforts have aimed at demonstrating the versatility of this transducer through the use of CMOS-compatible silicon nanowire transistors, 154 gold nanoparticle functionalized graphene FETs, 155 and p19 functionalized FETs, 156 with LODs of 0.13 fM, 10 fM, and 1 aM, respectively. The main drawback of this assay is the shallow sensing depth in solution, which is limited by the Debye length.…”

Section: Biosensor Methodsmentioning

confidence: 99%

Emerging Biosensing Approaches for microRNA Analysis

2015

View full text Add to dashboard Cite

show abstract

Section: Biosensor Methodsmentioning

confidence: 99%

Emerging Biosensing Approaches for microRNA Analysis

2015

View full text Add to dashboard Cite

show abstract

“…Nowadays, various biosensors have been used for nucleic acids detection such as electrochemical sensors (Pollet et al, 2009;Yang et al, 2014;Daniels et al, 2007;Pourmand and Fan, 2008;Berggren et al, 1998), field-effect transistor (FET) biosensor (Cai et al, 2014;Zheng et al, 2015;Cai et al, 2015;Zhang et al, 2010), optical systems (Huang et al, 2011;Akhavan et al, 2012;Panke et al, 2007;Aoki and Tao, 2007;Feng et al, 2008). In particular, most of them usually introduce one dimensional (1D) or two dimensional (2D) nanomaterials to improve sensitivity, and realize label-free detection, because of nanostructure's unique properties.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Sun

Liao

Zhang

et al. 2016

Biosensors and Bioelectronics

Self Cite

View full text Add to dashboard Cite

“…Decorating graphene membrane with metal nanoparticles affects the membrane sensitivity and selectivity [14]. Various nanoparticles (NPs) such as gold (Au) are commonly used to enhance its performance due to their recognized easy functionalization chemistry [15].…”

Section: Introductionmentioning

confidence: 99%

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

2020

View full text Add to dashboard Cite

DNA detection has revolutionized medical and biological research fields. It provides a wealth of medical information for each individual, which can be used in a personalized medicinal procedure in the future. Genome sequence helps to enhance our perception of inheritance, disease, and individuality. This work aims to improve DNA sequencing accuracy and the overall current signal using a novel nano pore based sensor that is developed to detect and identify the DNA bases. Herein, a novel z-shaped field effect transistor with a nano pore for the aim of DNA detection is studied, where a gate terminal is added below the center of the z-shaped graphene nano ribbon. First-principle transport calculations are used to identify the DNA bases and electronic signature. An efficient density functional theory approach combined with non-equilibrium Green's function formalism (DFT + NEGF) are utilized to detect the transmission spectrum and current for DNA nucleo bases: Adenine, Thymine, Guanine, and Cytosine. Using transmission current, a distinctive electronic signature is generated for each DNA base to detect each DNA sequence. Various orientations and lateral position for each DNA base are considered. Moreover, the effect of decorating the developed DNA sensor with gold and silver nanoparticles on the sensor's electrical current and transmission spectra is studied and analyzed. The results suggest that the z-shaped sensor could achieve DNA sequencing with high accuracy. The practical implementation of this work represents the capability to anticipate and cure diseases from the genetic makeup perspective.

show abstract

Gold nanoparticles-decorated graphene field-effect transistor biosensor for femtomolar MicroRNA detection

Cited by 176 publications

References 43 publications

Emerging Biosensing Approaches for microRNA Analysis

Emerging Biosensing Approaches for microRNA Analysis

Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

DNA sequencing via Z-shaped graphene nano ribbon field effect transistor decorated with nanoparticles using first-principle transport simulations

Contact Info

Product

Resources

About