Gold nanoparticles: current and upcoming biomedical applications in sensing, drug, and gene delivery

Yañez-Aulestia, Ana; Gupta, Nishesh Kumar; Hernández, Magali; Osorio-Toribio, Génesis; Sánchez-González, Elı́; Guzmán‐Vargas, Ariel; Rivera, Juan; Ibarra, Ilich A.; Lima, Enrique

doi:10.1039/d2cc04826d

Cited by 18 publications

(10 citation statements)

References 135 publications

(129 reference statements)

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“…These oligomeric Au 10–12 (SG) 10–12 nanoclusters can be obtained by the pH-controlled dissociation of water insoluble [Au(SG)] n without involving harmful reducing agents such as CO. Moreover, the isolated luminescent gold(I)–thiolate is also a promising nanomaterial for further pH-controlled reduction-based strategies (e.g., with sodium borohydride) in the development of novel biocompatible classical AuNCs and AuNPs ( Yanez-Aulestia et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

The first solid-state route to luminescent Au(I)—glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters for application in cancer radiotheraphy

et al. 2023

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There is still a need for synthetic approaches that are much faster, easier to scale up, more robust and efficient for generating gold(I)–thiolates that can be easily converted into gold–thiolate nanoclusters. Mechanochemical methods can offer significantly reduced reaction times, increased yields and straightforward recovery of the product, compared to the solution-based reactions. For the first time, a new simple, rapid and efficient mechanochemical redox method in a ball-mill was developed to produce the highly luminescent, pH-responsive Au(I)–glutathionate, [Au(SG)]n. The efficient productivity of the mechanochemical redox reaction afforded orange luminescent [Au(SG)]n in isolable amounts (mg scale), usually not achieved by more conventional methods in solution. Then, ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters were prepared by pH-triggered dissociation of [Au(SG)]n. The pH-stimulated dissociation of the Au(I)–glutathionate complex provides a time-efficient synthesis of oligomeric Au10–12(SG)10–12 nanoclusters, it avoids high-temperature heating or the addition of harmful reducing agent (e.g., carbon monoxide). Therefore, we present herein a new and eco-friendly methodology to access oligomeric glutathione-based gold nanoclusters, already finding applications in biomedical field as efficient radiosensitizers in cancer radiotherapy.

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Section: Discussionmentioning

confidence: 99%

The first solid-state route to luminescent Au(I)—glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters for application in cancer radiotheraphy

et al. 2023

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“…The extent to which the microporous levels are compromised when the mesopores are generated is an important consideration for the purpose of practical applications. 54,55 HFs are calculated for all of our hierarchically porous UiO-66-NH 2 samples studied in this work (see Table 2, as well as Table S7 in the Supporting Information) and the trend is visualized for the main samples as a three-dimensional (3D) plot in Figure 4. The G 14−6−14 templated mesoMOF samples HP-MOF-1 and HP-MOF-3 exhibit higher values of HF, whereas the samples with aggregation-based mesopores HP-MOF-2 and HP-MOF-4 have lower values of HF.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…59−61 In typical HP-silica-, zeolite-, and MOF-based mesoporous materials, a less hindered diffusion of larger substrate/reactant and the product molecules to get into and out of the solid catalysts through the better-connected mesoporous channels is expected. 55 It leads to an improved accessibility of the active catalytic sites. As a result, enhanced kinetic effects for the catalytic reactions have been previously observed in such HP materials.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Enhanced Catalytic Activity through the Variation of Hierarchical Porosity in a Zr-Based Metal–Organic Framework

Sunny,

Alagarsamy

2024

Chem. Mater.

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Herein, we present a study that demonstrates variation of the hierarchical porosity (HP) of metal−organic frameworks (MOFs) obtained by changes in the synthetic conditions, has significant effects on the accessibility of bulkier molecules toward the active sites in the HP MOFs and helps in overcoming the mass-transfer limitation. Two materials of UiO-66-NH 2 , HP-MOF-1 and HP-MOF-3, with narrow size distribution of mesopores around 5 nm and with higher relative meso-to microporous volumes have been obtained by surfactant-assisted synthesis using the gemini surfactant, G 14−6−14 , in water−ethanol mixed solvent compositions. A different pattern of HP has been observed for HP-MOF-2 and HP-MOF-4, with much broader mesoporous size distributions in the 10 to 25 nm range and lower relative meso-to microporous volumes that are obtained from similar but in the surfactant-/template-free synthetic conditions. Involvement of both the lamellar and vesicular mixed assembly of G 14−6−14 as a mesoporous template is demonstrated in the formation of HP-MOF-1 and HP-MOF-3. The broader pore-size distributions and higher external surface areas found in our HP-MOF-2 and HP-MOF-4, are attributed to the intercrystallite voids, which occur due to the aggregation of MOF nanoparticles in the template-free conditions. Dye-uptake studies in our MOF samples, involving bulky molecules of different shapes, sizes and charges, provided useful insights into the active-site accessibility and also about the mode of uptake. The HP-MOF-1 and HP-MOF-3 achieve faster kinetics and higher catalytic conversions of bulky fatty acids into corresponding methyl esters (biodiesels) compared to HP-MOF-2 and HP-MOF-4 and their microporous counterpart on account of the increased accessibility to the active sites and better mass transfer kinetics in the hierarchically connected micropores and mesopores.

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“…Colored substances may be originally present in the system or may be generated by certain reactions [ 81 , 82 ]. Some metal nanoparticles show different colors because of their different sizes and morphologies, such as gold nanoparticles (AuNPs) [ 83 ] and silver nanoparticles (AgNPs) [ 84 ]. The color changes can also be achieved using the catalysis of oxidoreductase, such as horseradish peroxidase (HRP) [ 85 ] and Glucose oxidase (GOD) [ 86 ].…”

Section: Stimulus-responsive Dna Hydrogel-based Biosensormentioning

confidence: 99%

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Wang

Lai

et al. 2023

Biosensors

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Food safety has always been a major global challenge to human health and the effective detection of harmful substances in food can reduce the risk to human health. However, the food industry has been plagued by a lack of effective and sensitive safety monitoring methods due to the tension between the cost and effectiveness of monitoring. DNA-based hydrogels combine the advantages of biocompatibility, programmability, the molecular recognition of DNA molecules, and the hydrophilicity of hydrogels, making them a hotspot in the research field of new nanomaterials. The stimulus response property greatly broadens the function and application range of DNA hydrogel. In recent years, DNA hydrogels based on stimulus-responsive mechanisms have been widely applied in the field of biosensing for the detection of a variety of target substances, including various food contaminants. In this review, we describe the recent advances in the preparation of stimuli-responsive DNA hydrogels, highlighting the progress of its application in food safety detection. Finally, we also discuss the challenges and future application of stimulus-responsive DNA hydrogels.

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Gold nanoparticles: current and upcoming biomedical applications in sensing, drug, and gene delivery

Cited by 18 publications

References 135 publications

The first solid-state route to luminescent Au(I)—glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters for application in cancer radiotheraphy

The first solid-state route to luminescent Au(I)—glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10–12(SG)10–12 nanoclusters for application in cancer radiotheraphy

Enhanced Catalytic Activity through the Variation of Hierarchical Porosity in a Zr-Based Metal–Organic Framework

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

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