Gold Nanoparticles Contact with Cancer Cell: A Brief Update

Abstract

The fine-tuning of the physicochemical properties of gold nanoparticles has facilitated the rapid development of multifunctional gold-based nanomaterials with diagnostic, therapeutic, and therapeutic applications. Work on gold nanoparticles is increasingly focusing on their cancer application. This review provides a summary of the main biological effects exerted by gold nanoparticles on cancer cells and highlights some critical factors involved in the interaction process (protein corona, tumor microenvironment, surface functionalization). The review also contains a brief discussion of the application of gold nanoparticles in target discovery.

Drug-Free Hybrid Nanoarchitecture Modulation of the Metastatic Behavior of Pancreatic Ductal Adenocarcinoma in Alternative in Vivo Models

“…The different behavior of AuNAs compared to other AuNPs is associated with the different morphology of the nanoplatforms. 46 For concentrations ≤1 μg/mL Cu, CuNAs stimulated cell metabolism at 24 h post-incubation and repressed it at 48 h. Interestingly, cell metabolism, hence cell viability, increased again close to the levels of untreated samples after 72 h. This trend can be related to copper release in cells. At 24 h post-incubation, the small leakage of copper from the whole NAs stimulated cell viability.…”

Green Synthesized Gold and Silver Nanoparticles Increased Oxidative Stress and Induced Cell Death in Colorectal Adenocarcinoma Cells

“…The different biological responses of tumor cells to the administration of nanoparticles depend on their physicochemical properties (shape, size, electrical charge and/or surface molecules), but also on the type of cells or tissue microenvironment [ 56 ].…”

Functionalized Gold Nanoparticles Suppress the Proliferation of Human Lung Alveolar Adenocarcinoma Cells by Deubiquitinating Enzymes Inhibition

“…In addition, when cells were exposed to a high concentration of functionalized AuNPs for 24 and 48 h, the proliferation of A549 cells relatively decreased. The decrease in cell proliferation at higher concentrations of AuNPs could be mediated by the insufficient nutrient provided in the CCM and more available number of AuNPs to interact with cellular components such as proteins, fatty acids, nucleic acid, and carbohydrates. ,, Based on the cell viability results, the capacity of A549 cells to recover from the detrimental effects caused by AuNPs was studied. Results on cell recovery demonstrated that A549 cells have the capacity to return to normal proliferation at low AuNP concentrations.…”